World Multiple Sclerosis Day, officially observed each year on 30 May, aims to foster global understanding and recognition of the challenges faced by those affected by multiple sclerosis (MS). It brings the global MS community together to share stories, raise awareness, and campaign for change. World MS Day was initiated in 2009 by the Multiple Sclerosis International Federation (MSIF) and its global members, including the National MS Society. It unites individuals and organizations from around the world to spotlight the impact of MS and bring us closer to a world free of this disease. To mark this important day, we are proud to present a curated collection of articles and Special Issues dedicated to groundbreaking research and innovative approaches in multiple sclerosis. We invite readers to explore these contributions and join us in supporting the global fight against multiple sclerosis.

“Harnessing Artificial Intelligence for the Diagnosis, Treatment and Research of Multiple Sclerosis”
by Manisha S. Patil, Linda Y. Lin, Rachel K. Ford, Elizaveta J. James, Stella Morton, Felix Marsh-Wakefield, Simon Hawke and Georges E. Grau
Sclerosis 2025, 3(2), 15; https://doi.org/10.3390/sclerosis3020015

“Behavioral Activation Therapy for Multiple Sclerosis: Potential Effects on Cognition, Neuropsychiatric Symptoms, and Quality of Life”
by Daniela Taranu, Hayrettin Tumani, Visal Tumani and Patrick Fissler
Sclerosis 2025, 3(2), 12; https://doi.org/10.3390/sclerosis3020012

“Health Locus of Control and Its Relationship with Quality of Life and Functioning in Multiple Sclerosis: Exploring the Mediating Role of Self-Efficacy”
by Isaac Rothman, Alan Tennant, Roger Mills  and Carolyn Young
Sclerosis 2025, 3(2), 10; https://doi.org/10.3390/sclerosis3020010

“The Use of Augmented Reality on a Self-Paced Treadmill to Quantify Attention and Footfall Placement Variability in Middle-Aged to Older-Aged Adults with Multiple Sclerosis”
by Manuel E. Hernandez, Roee Holtzer, Meltem Izzetoglu and Robert W. Motl
Sclerosis 2025, 3(1), 3; https://doi.org/10.3390/sclerosis3010003

“A 2-Year Longitudinal Neuropsychological Study in Relapsing-Remitting Multiple Sclerosis: A Selective Decline in Social Cognition?”
by Nathalie Ehrle and Margot Papinsac
Sclerosis 2024, 2(4), 365–377; https://doi.org/10.3390/sclerosis2040024

“Resilience, Mental Health, Sleep, and Smoking Mediate Pathways Between Lifetime Stressors and Multiple Sclerosis Severity”
by Carri S. Polick, Hala Darwish, Leonardo Pestillo de Oliveira, Ali Watson, Joao Ricardo Nickenig Vissoci, Patrick S. Calhoun, Robert J. Ploutz-Snyder, Cathleen M. Connell, Tiffany J. Braley and Sarah A. Stoddard
Sclerosis 2024, 2(4), 341–354; https://doi.org/10.3390/sclerosis2040022

“Assessing the Relationship between Personality Traits and Clinical Aspects in Individuals with Multiple Sclerosis”
by Cosima Meier, Andreas Edelmann, Marlon Pflüger and Pasquale Calabrese
Sclerosis 2024, 2(3), 266–279; https://doi.org/10.3390/sclerosis2030016

“Pseudobulbar Affect in Patients with Multiple Sclerosis: A Systematic Review”
by Silvia Chiereghin, Giulia Purpura, Anna Riva, Renat Nacnovich and Andrea Eugenio Cavanna
Sclerosis 2024, 2(3), 186–198; https://doi.org/10.3390/sclerosis2030013

“Diet-Induced Changes in Functional Disability among People with Multiple Sclerosis: A Secondary Pooled Analysis of Two Randomized Controlled Pilot Trials”
by Allison R. Groux, Elizabeth S. Walker, Farnoosh Shemirani, Jennifer E. Lee, Amanda K. Irish, Linda M. Rubenstein, Linda G. Snetselaar, Warren G. Darling, Terry L. Wahls and Tyler J. Titcomb
Sclerosis 2024, 2(3), 156–165; https://doi.org/10.3390/sclerosis2030011

“Risk Factors for Cognitive Impairment in Multiple Sclerosis Patients”
by Thomas Gabriel Schreiner, lustina Mihoc, Ecaterina Grigore and Oliver Daniel Schreiner
Sclerosis 2024, 2(2), 77–87; https://doi.org/10.3390/sclerosis2020006

“Neuropsychiatric and Quality of Life (QoL) Aspects of Multiple Sclerosis, 2nd Edition” Guest Editor: Prof. Dr. Pasquale Calabrese Submission deadline: 20 October 2025	“Exploring Environmental Risk Factors for Disease Progression in Multiple Sclerosis and Amyotrophic Lateral Sclerosis” Guest Editors: Dr. Maurizio A. Leone and Dr. Radu Tanasescu Submission deadline: 20 February 2026