Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence
Abstract
:1. Introduction
2. Evidence of MSU Crystals in Vessels of Patients with Gout
2.1. Histological Evidence
2.2. Imaging Evidence: The Debate on the Evidence Gathered with DECT
3. Evidence of MSU Crystals in Vessels of Patients without Gout
3.1. Histological Evidence
3.2. Biochemical Characterization of Urate Presence in Atherosclerotic Plaques
3.3. Vascular DECT Scans in Patients without Gout
Study | Year | Subjects | Studied Arteries | MSU Crystal Present in Vessels | Technique of Crystal Identification | Urate Plaque Concentration | Xanthine Oxidase Activity | Chemical Characterization of MSU Crystals |
---|---|---|---|---|---|---|---|---|
Klauser A.S. et al. [13] | 2019 | 6 cadaveric donors | Coronary and Aorta | Yes | Polarized light microscopy and Dual-energy CT | - | - | No |
Park J.J. et al. [26] | 2014 | 55 explanted hearts | Coronary | Yes | Polarized light microscopy | - | - | No |
Patetsios P. et al. [28] | 2001 | 23 endarterectomy samples vs. 10 cadaveric donors | Carotid | Yes | Polarized light microscopy and staining | Increased | Increased | Yes (questionable specificity) |
Nardi V. et al. [29] | 2022 | 32 endarterectomy samples | Carotid | Unreported | - | Increased | Increased | - |
Kim S.C. et al. [31] | 2018 | 44 patients | Carotid | No | Dual-energy CT | - | - | - |
4. If DECT-Based MSU-Coded Plaques in Vessels Are Not Made of MSU Crystals, What Are They?
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Year | Subjects | Studied Arteries | MSU Crystal Present in Vessels | Technique of Crystal Identification | Chemical Characterization of MSU Crystals |
---|---|---|---|---|---|---|
Traut E.F. et al. [12] | 1954 | 2 cadaveric donors with gout | Coronary | Yes | Polarized light microscopy | No |
Lievin M.H. et al. [14] | 1956 | 11 cadaveric donors with gout | Coronary and Aorta | No | Polarized light microscopy | No |
Klauser A.S. et al. [13] | 2019 | 59 Patients | Coronary and Aorta | Yes | Dual-energy CT | No |
Barazani S. et al. [21] | 2020 | 31 patients | Coronary and Aorta | Yes | Dual-energy CT | No |
Feuchtner G.M. et al. [22] | 2021 | 37 Patients | Coronary and Aorta | Yes | Dual-energy CT | No |
Dalbeth N. et al. [19] | 2022 | 6 cadaveric donors | Aorta | No (doubt on 1 crystal) | Polarized light microscopy | No |
Pascart T. et al. [24] | 2021 | 126 patients | Popliteal arteries | No | Dual-energy CT | Non-invasive (DECT parameter analysis) |
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Pascart, T.; Budzik, J.-F. Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence. Gout Urate Cryst. Depos. Dis. 2023, 1, 208-216. https://doi.org/10.3390/gucdd1030017
Pascart T, Budzik J-F. Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence. Gout, Urate, and Crystal Deposition Disease. 2023; 1(3):208-216. https://doi.org/10.3390/gucdd1030017
Chicago/Turabian StylePascart, Tristan, and Jean-François Budzik. 2023. "Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence" Gout, Urate, and Crystal Deposition Disease 1, no. 3: 208-216. https://doi.org/10.3390/gucdd1030017
APA StylePascart, T., & Budzik, J. -F. (2023). Does Monosodium Urate Crystal Vascular Deposition Exist? Review of the Evidence. Gout, Urate, and Crystal Deposition Disease, 1(3), 208-216. https://doi.org/10.3390/gucdd1030017