Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia
, Amber Driesen 1, Maaike Van Trimpont 2,3,4,5, Claudia Theys 1, Emilie Logie 1, Pieter Van Vlierberghe 2,3,4 and Wim Vanden Berghe 1,*Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe review manuscript titled " Epigenetic rewiring of protein kinase signalling in T-Cell Acute Lymphoblastic Leukaemia" offers perspectives on epigenetic regulatory aspects of kinase signalling heterogeneity in T-ALL pathogenesis and therapeutic outcome. While compelling, the manuscript would benefit from several improvements to enhance its clarity, structure, and overall impact for publication:
1. The manuscript can benefit from incorporating T-ALL specific kinases and their specific epigentic regulatory roles I disease progression.
2. The author could include a concise overview of common therapeutic targets in T-ALL, along with conventional chemotherapy agents and targeted therapies, in the introduction section.
3. The highly heterogeneous nature of T-ALL underscores the need for a thorough analysis of how hypoxic processes and the tumor microenvironment influence tumor development and treatment. In this context, the authors could explore the complex interplay between these factors and associate kinases.
4. The manuscript could benefit from a table providing a concise overview of kinase-based therapeutic targets and approaches for T-ALL, which is currently missing.
5. Authors should also discuss the advantages and potential limitations of kinase-based therapies to provide a balanced perspective.
6. Authors might need to revise heading 4 at 557 as it is unclear that what authors might want to say. Does author mean histone modifications impacted by kinases in T-ALL.
7. Section 4 requires a graphical illustration to summarize the information provided in the section.
8. The manuscript will be hugely benefit from a table highlighting major epigenetic phosphorylation sites, associated kinases in T-ALL.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsThe authors provide a comprehensive review on the epigenetic regulation of ALL. Overall, this review is of high quality and readership.
The only issue I have is that it would have been more comprehensive if the authors could include a section of current and potential therapeutic approaches targeting the epigenetic signaling of ALL.
Author Response
Please see the attachment + we have added a supplementary document of our revised manuscript with tracked changes
Author Response File: Author Response.pdf
