A Retrospective Review of Dual-Focus MiSight Contact Lenses and 0.05% Atropine for Myopia Management
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
| ANOVA | Analysis of variance |
| ATOM2 | Atropine for the Treatment of Myopia |
| BCVA | best corrected visual acuity |
| D | Diopter |
| IQR: | Interquartile range |
| LAMP | Low-concentration Atropine for Myopia Progression |
References
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| MiSight, n = 55 (%) | 0.05% Atropine, n = 45 (%) | p-Value | |
|---|---|---|---|
| Age (years) | 10.4 ± 2.1 | 8.4 ± 2.5 | <0.01 |
| Median 10.4, IQR [8.9, 12.5] | Median 8.9, IQR [6.6, 10.3] | ||
| Range 5.3 to 13.9 | Range 2.8 to 13.1 | ||
| Gender (M:F) | 26:29:00 | 27:18:00 | 0.23 |
| (47%:53%) | (60%:40%) | ||
| Race | 0.33 | ||
| Caucasian | 26 (47%) | 17 (38%) | |
| Black | 1 (1.8%) | 4 (9%) | |
| Asian | 16 (29%) | 10 (22%) | |
| Other | 10 (18%) | 13 (29%) | |
| Multiple Races | 1 (1.8%) | 0 (0%) | |
| Declined/Unknown | 1 (1.8%) | 1 (2%) | |
| Ethnicity | <0.05 | ||
| Hispanic | 7 (13%) | 15 (33%) | |
| Non-Hispanic | 48 (87%) | 30 (67%) |
| MiSight (n = 55) (Mean ± SD) | 0.05% Atropine (n = 45) (Mean ± SD) | |
|---|---|---|
| Baseline BCVA | 0.03 ± 0.07 | 0.07 ± 0.14 |
| Baseline Sphere (Diopters) | −3.59 ± 1.50 | -4.18 ± 1.90 |
| Baseline Cylinder (Diopters) | 0.35 ± 0.49 | 0.93 ± 1.21 |
| Baseline Spherical Equivalent (Diopters) | −3.42 ± 1.41 | −3.71 ± 1.79 |
| Baseline Axial Length (mm) | 24.82 ± 0.96 | 24.74 ± 1.36 |
| 1-Year BCVA | 0.03 ± 0.07 (p = 0.74) | 0.05 ± 0.11 (p = 0.55) |
| 1-Year Spherical Equivalent (Diopters) | −3.58 ± 1.48 (p = 0.61) | −3.82 ± 1.92 (p = 0.78) |
| 1-Year Axial Length (mm) | 24.86 ± 0.98 (p = 0.98) | 24.76 ± 1.23 (p = 0.97) |
| MiSight | Atropine 0.05% | |||||
|---|---|---|---|---|---|---|
| <9.5 Years (n = 19) (Mean ± SD) | 9.5 Years and Older (n = 36) (Mean ± SD) | p-Value | <9.5 Years (n = 27) (Mean ± SD) | 9.5 Years and Older (n = 18) (Mean ± SD) | p-Value | |
| Age (Years) | 8.1 ± 1.1 | 11.6 ± 1.45 | <0.01 | 6.7 ± 1.9 | 10.8 ± 1.0 | <0.01 |
| Baseline Sphere (Diopters) | −3.25 ± 1.49 | −3.77 ± 1.345 | 0.22 | −4.19 ± 1.94 | −4.17 ± 1.78 | 0.97 |
| Baseline Cylinder (Diopters) | 0.30 ± 0.50 | 0.37 ± 0.48 | 0.64 | 0.78 ± 0.86 | 1.15 ± 1.55 | 0.32 |
| Baseline Spherical Equivalent (Diopters) | −3.10 ± 1.40 | −3.59 ± 1.39 | 0.23 | −3.80 ± 1.80 | −3.59 ± 1.80 | 0.71 |
| Baseline Axial Length (mm) | 24.63 ± 0.92 | 24.91 ± 0.93 | 0.42 | 24.56 ± 1.53 | 24.97 ± 0.98 | 0.51 |
| 1-Year Spherical Equivalent (Diopters) | −3.34 ± 1.50 (p = 0.62) | −3.70 ± 1.43 (p = 0.74) | 0.42 | −3.94 ± 2.01 (p = 0.79) | −3.67 ± 1.72 (p = 0.88) | 0.65 |
| 1-Year Axial Length (mm) | 24.81 ± 0.93 (p = 0.71) | 24.88 0.98 (p = 0.94) | 0.84 | 24.67 ± 1.27 (p = 0.84) | 24.90 ± 1.10 (p = 0.88) | 0.66 |
| MiSight | Atropine | |||||
|---|---|---|---|---|---|---|
| ≤−3.50 D (n = 29) (Mean ± SD) | >−3.50 D (n = 26) (Mean ± SD) | p-Value | ≤−3.50 D (n = 27) (Mean ± SD) | >−3.50 D (n = 18) (Mean ± SD) | p-Value | |
| Age (Years) | 10.2 ± 2.2 | 10.5 ± 2.1 | 0.72 | 8.1 ± 2.7 | 8.7 ± 2.6 | 0.47 |
| Baseline Sphere (Diopters) | −4.78 ± 0.94 | −2.26 ± 0.61 | <0.01 | −5.08 ± 1.27 | −2.57 ± 1.12 | <0.01 |
| Baseline Cylinder (Diopters) | 0.50 ± 0.58 | 0.17 ± 0.29 | 0.02 | 0.82± 0.75 | 1.08 ± 1.70 | 0.49 |
| Baseline Spherical Equivalent (Diopters) | −4.53 ± 0.90 | −2.22 ± 0.53 | <0.01 | −4.84 ± 1.35 | −2.03 ± 0.73 | <0.01 |
| Baseline Axial Length (mm) | 25.53 ± 0.71 | 24.41 ± 0.86 | <0.01 | 25.44 ± 0.90 | 24.05 ± 1.43 | 0.02 |
| 1 Year Spherical Equivalent (Diopters) | −4.72 ± 1.02 (p = 0.46) | −2.29 ± 0.57 (p = 0.64) | <0.01 | −4.99 ± 1.47 (p = 0.69) | −2.15 ± 1.06 (p = 0.70) | <0.01 |
| 1 Year Axial Length (mm) | 25.32 ± 0.89 (p = 0.64) | 24.33 ± 0.80 (p = 0.81) | <0.01 | 25.24 ± 0.88 (p = 0.60) | 24.19 ± 1.38 (p = 0.82) | 0.03 |
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Shaikh, N.; Stec, M.; Yin, H.; Bohnsack, B.L. A Retrospective Review of Dual-Focus MiSight Contact Lenses and 0.05% Atropine for Myopia Management. J. Clin. Transl. Ophthalmol. 2026, 4, 1. https://doi.org/10.3390/jcto4010001
Shaikh N, Stec M, Yin H, Bohnsack BL. A Retrospective Review of Dual-Focus MiSight Contact Lenses and 0.05% Atropine for Myopia Management. Journal of Clinical & Translational Ophthalmology. 2026; 4(1):1. https://doi.org/10.3390/jcto4010001
Chicago/Turabian StyleShaikh, Noreen, Magdalena Stec, Huizi Yin, and Brenda L. Bohnsack. 2026. "A Retrospective Review of Dual-Focus MiSight Contact Lenses and 0.05% Atropine for Myopia Management" Journal of Clinical & Translational Ophthalmology 4, no. 1: 1. https://doi.org/10.3390/jcto4010001
APA StyleShaikh, N., Stec, M., Yin, H., & Bohnsack, B. L. (2026). A Retrospective Review of Dual-Focus MiSight Contact Lenses and 0.05% Atropine for Myopia Management. Journal of Clinical & Translational Ophthalmology, 4(1), 1. https://doi.org/10.3390/jcto4010001

