Clinical Features and Predictors for Mortality in Neurolisteriosis: An Administrative Data-Based Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Feature Engineering and Preprocessing
2.3. Analyses of Features
3. Results
3.1. Descriptive Analyses
3.2. Bivariate and Multivariate Analyses
4. Discussion
Limitations
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ICD-9 | International Classification of Diseases, 9th Revision |
ICD-10 | International Classification of Diseases, 10th Revision |
MBDS | Minimum Basic Data Set |
COPD | Chronic obstructive pulmonary disease |
CKD | Chronic kidney disease |
OR | Odds ratio |
CNS | Central nervous system |
EU | European Union |
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Feature Name | Type |
---|---|
Patient’s hospital medical record number (hash) | numeric |
Patient identifier (hash) | numeric |
Department | categorical |
Date of birth | date |
Date of admission | date |
Date of discharge | date |
Type of discharge | categorical |
Main diagnosis + 14 secondary diagnoses (if applicable) | categorical |
Main procedure + 20 secondary procedures (if applicable) | categorical |
Type of admission (urgent/scheduled) | categorical |
Hospital (hash) | numeric |
Postal code | categorical |
Billing/insurance type | categorical |
Date of surgical intervention | date |
Total (n = 5180) | Neurolisteriosis (n = 2313) | |
---|---|---|
Sex (women) | 2130 (41.1%) | 815 (35.2%) |
Newborns | 291 (5.6%) | 112 (4.8%) |
Pregnancy | 281 (5.4%) | 1 (0.001%) |
Adults | 4889 (94.4%) | 2.201 (95%) |
Age, all patients (median) | 65 (22.6) | 64 (21.2) |
Age, only adults (median) | 66 (18.2) | 65 (22.6) |
Clinical presentation | ||
Neurological (all) | 2313 (44.7%) | 2313 (100%) |
Meningitis | 2090 (40.3%) | 2090 (90.4%) |
Encephalomyelitis | 156 (3.0%) | 156 (6.7%) |
Intracranial abscess | 113 (2.2%) | 113 (4.9%) |
Endocarditis | 45 (0.9%) | 8 (0.3%) |
Febrile gastroenteritis | 212 (4.1%) | 51 (2.2%) |
Sepsis/septic shock | 465 (9.0%) | 167 (7.2%) |
Death | 879 (17.0%) | 443 (19.2%) |
Comorbidities | ||
Diabetes mellitus | 822 (15.9%) | 340 (14.7%) |
COPD | 492 (9.5%) | 219 (9.5%) |
Chronic liver disease | 710 (13.7%) | 247 (10.7%) |
Chronic kidney disease | 468 (9.0%) | 124 (5.4%) |
Immunosuppression | 2.222 (42.9%) | 810 (35%) |
Malignancy | 1341 (25.9%) | 412 (17.8%) |
Mortality (n = 443) | Survival (n = 1870) | p-Value | |
---|---|---|---|
Sex (women) | 168 (37.9%) | 647 (34.6%) | 0.207 |
Newborns | 5 (1.1%) | 107 (5.7%) | <0.001 |
Pregnancy | 0 (0.0%) | 1 (0.1%) | 0.999 |
Age, in years (median, IQR) | 73 (15.9) | 62 (21.6) | <0.001 |
CNS involvement | |||
Meningitis | 403 (91%) | 1687 (90.2%) | 0.692 |
Encephalomyelitis | 33 (7.4%) | 123 (6.6%) | 0.580 |
Intracranial abscess | 23 (5.2%) | 90 (4.8%) | 0.833 |
Other manifestations | |||
Endocarditis | 2 (0.5%) | 6 (0.3%) | 0.999 |
Febrile gastroenteritis | 5 (1.1%) | 46 (2.5%) | 0.124 |
Sepsis/septic shock | 78 (17.6%) | 89 (4.8%) | <0.001 |
Comorbidities | |||
Diabetes mellitus | 74 (16.7%) | 266 (14.2%) | 0.211 |
COPD | 46 (10.4%) | 173 (9.3%) | 0.521 |
Chronic liver disease | 62 (14%) | 185 (9.9%) | 0.150 |
CKD | 45 (10.2%) | 79 (4.2%) | <0.001 |
Immunosuppression | 195 (44%) | 615 (32.9%) | <0.001 |
Malignancy | 130 (29.3%) | 282 (15.1%) | <0.001 |
Odds Ratio | 2.5% | 97.5% | p-Value | |
---|---|---|---|---|
Age | 1.039 | 1.031 | 1.047 | <0.001 |
Sepsis/septic shock | 4.527 | 3.190 | 6.430 | <0.001 |
Chronic liver disease | 1.625 | 1.161 | 2.250 | 0.004 |
CKD | 2.048 | 1.355 | 3.061 | <0.001 |
Immunosuppression | 1.133 | 0.838 | 1.521 | 0.410 |
Malignancy | 2.154 | 1.540 | 3.025 | <0.001 |
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Garcia-Carretero, R. Clinical Features and Predictors for Mortality in Neurolisteriosis: An Administrative Data-Based Study. Bacteria 2022, 1, 3-11. https://doi.org/10.3390/bacteria1010002
Garcia-Carretero R. Clinical Features and Predictors for Mortality in Neurolisteriosis: An Administrative Data-Based Study. Bacteria. 2022; 1(1):3-11. https://doi.org/10.3390/bacteria1010002
Chicago/Turabian StyleGarcia-Carretero, Rafael. 2022. "Clinical Features and Predictors for Mortality in Neurolisteriosis: An Administrative Data-Based Study" Bacteria 1, no. 1: 3-11. https://doi.org/10.3390/bacteria1010002