Next Article in Journal
Recovery of Antioxidant Compounds from Exhausted Olive Pomace through Microwave-Assisted Extraction
Previous Article in Journal
Effects of Alkalinity-Induced Iron Deficiency on Physiological and Growth Variables of Some Upland Rice Cultivars under Laboratory Condition
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

In Vitro Hypolipidemic and Hypoglycaemic Properties of Mushroom Extracts †

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
2
Museum of Natural History of Calabria and Botanic Garden, University of Calabria, 87036 Rende, Italy
3
Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy
4
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy
5
UFR de Pharmacie de Paris, CNRS UMR 8038, CiTCoM, Université de Paris, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Presented at the 2nd International Electronic Conference on Foods—Future Foods and Food Technologies for a Sustainable World, 15–30 October 2021; Available online: https://foods2021.sciforum.net/.
Biol. Life Sci. Forum 2021, 6(1), 61; https://doi.org/10.3390/Foods2021-10925
Published: 13 October 2021

Abstract

:
Mushrooms are considered a valuable food due to their unique taste, nutritional properties, and biological effects [1]. They are a source of several classes of phytochemicals, including phenols, terpenoids, steroids, and polysaccharides that demonstrate a wide range of biological activities [2]. Obesity is a metabolic disorder, which results from the excessive accumulation of body fat, associated with several comorbidities, including cardiovascular diseases, hypertension, various types of cancer, and type 2 diabetes mellitus [3]. Several natural compounds possess the ability to reduce body weight and to prevent diet-induced obesity by inhibiting enzymes that interfere with the hydrolysis and absorption of dietary carbohydrates and lipids, such as alpha-amylase, alpha-glucosidase, and pancreatic lipase [4,5]. This study was constructed to investigate the hypoglycaemic and hypolipidemic activity of Leccinum duriusculum and Lanmaoa fragrans (=Boletus fragrans) from Calabria (southern Italy), two symbiotic edible mushrooms belonging to the Boletaceae family, growing the former in poplar tree forests and the latter in a mycorrhizal association with oaks. Both mushrooms were dried and exhaustively extracted by maceration with n-hexane, dichloromethane, and methanol. Extracts were investigated for their inhibitory activity against alpha-amylase, alpha-glucosidase, and lipase [6]. The best results against alpha-glucosidase and alpha-amylase were obtained with L. duriusculum methanol and dichloromethane extracts, respectively. The methanol extracts of both species exhibited the most promising results in inhibiting lipase (IC50 of 35.02 and 22.40 μg/mL, for L. duriusculum and L. fragrans, respectively, vs. IC50 of 37.63 μg/mL for the positive control orlistat). These data provided evidence that both species are able to inhibit key enzymes that interfere with the hydrolysis and absorption of dietary carbohydrates and lipids, suggesting their potential use for the development of new potential agents for the management of obesity and type 2 diabetes mellitus. However, further research is required to confirm these effects in vivo.

Author Contributions

Conceptualization, R.T., N.G.P. and B.D.; investigation, M.B., M.C.T., G.S., F.F. and M.R.L.; writing—original draft preparation, L.T., M.B., R.T. and B.D.; writing—review and editing, R.T., M.R.L. and L.T.; supervision, R.T., N.G.P. and B.D. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Heleno, S.A.; Barros, L.; Martins, A.; Morales, P.; Fernandez-Ruiz, V.; Glamoclija, J.; Sokovic, M.; Ferreira, I.C. Nutritional value, bioactive compounds, antimicrobial activity and bioaccessibility studies with wild edible mushrooms. LWT-Food Sci. Technol. 2015, 63, 799–806. [Google Scholar] [CrossRef] [Green Version]
  2. Sokovic, M.; Ciric, M.; Glamocija, J.; Stojković, D. The bioactive properties of mushrooms. In Wild Plants, Mushrooms and Nuts: Functional Food Properties and Applications, 1st ed.; Ferreira, I.C.F.R., Morales, P., Barros, L., Eds.; John Wiley & Sons, Ltd.: Chichester, UK, 2016; pp. 83–122. [Google Scholar]
  3. Kitahara, C.M.; Flint, A.J.; Berrington de Gonzalez, A.; Bernstein, L.; Brotzman, M.; MacInnis, R.J.; Moore, S.C.; Robien, K.; Rosenberg, P.S.; Singh, P.N.; et al. Association between class III obesity (BMI of 40–59 kg/m2) and mortality: A pooled analysis of 20 prospective studies. PLoS Med. 2014, 11, e1001673. [Google Scholar] [CrossRef] [PubMed]
  4. Yun, J.W. Possible anti-obesity therapeutics from nature-a review. Phytochemistry 2010, 71, 1625–1641. [Google Scholar] [CrossRef] [PubMed]
  5. Nair, S.S.; Kavrekar, V.; Mishra, A. In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts. Eur. J. Exp. Biol. 2013, 3, 128–132. [Google Scholar]
  6. Tundis, R.; Conidi, C.; Loizzo, M.R.; Sicari, V.; Romeo, R.; Cassano, A. Concentration of bioactive phenolic compounds in olive mill wastewater by direct contact membrane distillation. Molecules 2021, 26, 1808. [Google Scholar] [CrossRef] [PubMed]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Tundis, R.; Passalacqua, N.G.; Tenuta, M.C.; Bonesi, M.; Sicoli, G.; Trabalzini, L.; Finetti, F.; Deguin, B.; Loizzo, M.R. In Vitro Hypolipidemic and Hypoglycaemic Properties of Mushroom Extracts. Biol. Life Sci. Forum 2021, 6, 61. https://doi.org/10.3390/Foods2021-10925

AMA Style

Tundis R, Passalacqua NG, Tenuta MC, Bonesi M, Sicoli G, Trabalzini L, Finetti F, Deguin B, Loizzo MR. In Vitro Hypolipidemic and Hypoglycaemic Properties of Mushroom Extracts. Biology and Life Sciences Forum. 2021; 6(1):61. https://doi.org/10.3390/Foods2021-10925

Chicago/Turabian Style

Tundis, Rosa, Nicodemo G. Passalacqua, Maria C. Tenuta, Marco Bonesi, Giovanni Sicoli, Lorenza Trabalzini, Federica Finetti, Brigitte Deguin, and Monica R. Loizzo. 2021. "In Vitro Hypolipidemic and Hypoglycaemic Properties of Mushroom Extracts" Biology and Life Sciences Forum 6, no. 1: 61. https://doi.org/10.3390/Foods2021-10925

APA Style

Tundis, R., Passalacqua, N. G., Tenuta, M. C., Bonesi, M., Sicoli, G., Trabalzini, L., Finetti, F., Deguin, B., & Loizzo, M. R. (2021). In Vitro Hypolipidemic and Hypoglycaemic Properties of Mushroom Extracts. Biology and Life Sciences Forum, 6(1), 61. https://doi.org/10.3390/Foods2021-10925

Article Metrics

Back to TopTop