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Biology and Life Sciences Forum
Volume 20
Issue 1
10.3390/IECBM2022-13379
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Abstract

Effects of Glucocorticoid Receptor Activation on the Expression of Intercellular Adhesion Regulatory Genes in Breast Cancer Cells In Vitro †

by
Diana Grigoreva
1,*,
Ekaterina Zhidkova
1,
Olga Zhukova
2,
Ekaterina Lesovaya
1,3 and
Marianna Yakubovskaya
1
1
N.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia
2
Department of Biotechnology and Industrial Pharmacy, Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University, 119454 Moscow, Russia
3
Department of Oncology, I.P. Pavlov Ryazan State Medical University, 390026 Ryazan, Russia
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Electronic Conference on Biomolecules: Biomacromolecules and the Modern World Challenges, 1–15 November 2022; Available online: https://iecbm2022.sciforum.net/.
Biol. Life Sci. Forum 2022, 20(1), 11; https://doi.org/10.3390/IECBM2022-13379
Published: 1 November 2022
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Biomolecules: Biomacromolecules and the Modern World Challenges)
Versions Notes

Abstract

:
Combinations of anticancer chemotherapeutics with glucocorticoids (GCs) are usually used to broaden the therapeutic range of main cytostatic agents and to diminish the side effects of chemotherapy. However, long-term GC administration leads to tumor resistance and the promotion of metastasis. GC effects are mediated by the glucocorticoid receptor, which regulates gene expression via DNA-dependent transactivation associated with GC side effects and therapeutically important transrepression. We aimed to determine the molecular markers associated with the GC-stimulated motility and migration of breast cancer cells. We showed that GCs stimulate the invasion and metastasis of breast cancer cells after 120 h of treatment and determined markers of GC-associated adhesion loss.

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/IECBM2022-13379/s1.

Author Contributions

Conceptualization, E.L. and M.Y.; methodology, E.Z.; software, D.G.; validation, E.Z., D.G. and O.Z.; formal analysis, E.Z.; investigation, D.G.; resources, M.Y.; data curation, E.Z.; writing—original draft preparation, D.G.; writing—review and editing, E.L.; visualization, O.Z.; supervision, E.L.; project administration, M.Y.; funding acquisition, E.L. All authors have read and agreed to the published version of the manuscript.

Funding

Work was partially supported by RSCF (17-75-20124) and RFBR (16-04-01410, 15-04-04006).

Data Availability Statement

The data presented in this study are available on request from the corresponding author.

Conflicts of Interest

The authors declare no conflict of interest.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Grigoreva, D.; Zhidkova, E.; Zhukova, O.; Lesovaya, E.; Yakubovskaya, M. Effects of Glucocorticoid Receptor Activation on the Expression of Intercellular Adhesion Regulatory Genes in Breast Cancer Cells In Vitro. Biol. Life Sci. Forum 2022, 20, 11. https://doi.org/10.3390/IECBM2022-13379

AMA Style

Grigoreva D, Zhidkova E, Zhukova O, Lesovaya E, Yakubovskaya M. Effects of Glucocorticoid Receptor Activation on the Expression of Intercellular Adhesion Regulatory Genes in Breast Cancer Cells In Vitro. Biology and Life Sciences Forum. 2022; 20(1):11. https://doi.org/10.3390/IECBM2022-13379

Chicago/Turabian Style

Grigoreva, Diana, Ekaterina Zhidkova, Olga Zhukova, Ekaterina Lesovaya, and Marianna Yakubovskaya. 2022. "Effects of Glucocorticoid Receptor Activation on the Expression of Intercellular Adhesion Regulatory Genes in Breast Cancer Cells In Vitro" Biology and Life Sciences Forum 20, no. 1: 11. https://doi.org/10.3390/IECBM2022-13379

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