An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of DAC
2.2. Multispecies Subgingival Biofilm Model
2.3. Metabolic Activity of Biofilm
2.4. DNA-DNA Hybridization (Checkerboard Technique)
2.5. Determination of Acute Toxic Potential in an Alternative In Vivo Model
2.6. Statistical Analysis
3. Results
Antibiofilm Activity of DAC
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Bacteria | ATCC | Bacteria | ATCC |
---|---|---|---|
Actinomyces naeslundii | ATCC12104 | Actinomyces oris | ATCC43146 |
Actinomyces gerencseriae | ATCC23840 | Actinomyces israelii | ATCC12102 |
Veillonella parvula | ATCC10790 | Actinomyces odontolyticus | ATCC17929 |
Streptococcus sanguinis | ATCC10556 | Streptococcus oralis | ATCC35037 |
Streptococcus intermedius | ATCC27335 | Streptococcus gordonii | ATCC10558 |
Streptococcus mitis | ATCC49456 | Aggregatibacter actinomycetemcomitans | ATCC29523 |
Capnocytophaga ochracea | ATCC33596 | Capnocytophaga gingivalis | ATCC33624 |
Eikenella corrodens | ATCC23834 | Capnocytophaga sputigena | ATCC33612 |
Streptococcus constellatus | ATCC27823 | Eubacterium nodatum | ATCC33099 |
Fusobacterium nucleatum vincentii | ATCC49256 | Parvimonas micra | ATCC33270 |
Fusobacterium nucleatum polymorphum | ATCC10953 | Fusobacterium nucleatum nucleatum | ATCC25586 |
Campylobacter showae | ATCC51146 | Capnocytophaga sputigena | ATCC33612 |
Campylobacter gracilis | ATCC33236 | Leptotrichia buccalis | ATCC14201 |
Campylobacter rectus | ATCC33238 | Fusobacterium periodonticum | ATCC33693 |
Prevotella intermedia | ATCC25611 | Porphyromonas gingivalis | ATCC33277 |
Tannerella forsythia | ATCC43037 | Prevotella melaninogenica | ATCC25845 |
Prevotella nigrescens | ATCC33563 | Eubacterium saburreum | ATCC33271 |
Streptococcus anginosus | ATCC33397 | Selenomonas noxia | ATCC43541 |
Neisseria mucosa | ATCC19696 | Propionibacterium acnes | ATCC11827 |
Gemella morbillorum | ATCC27824 | Streptococcus mutans | ATCC25175 |
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Aires da Silva, V.A.; Bueno-Silva, B.; Figueiredo, L.C.; Tiemi Macedo, T.; Aguiar da Silva, L.D.; Chagas Chaves de Oliveira Junior, H.; Polaquini, C.R.; Regasini, L.O.; Sardi, J.d.C.O. An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms. Future Pharmacol. 2025, 5, 19. https://doi.org/10.3390/futurepharmacol5020019
Aires da Silva VA, Bueno-Silva B, Figueiredo LC, Tiemi Macedo T, Aguiar da Silva LD, Chagas Chaves de Oliveira Junior H, Polaquini CR, Regasini LO, Sardi JdCO. An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms. Future Pharmacology. 2025; 5(2):19. https://doi.org/10.3390/futurepharmacol5020019
Chicago/Turabian StyleAires da Silva, Valdo Antonio, Bruno Bueno-Silva, Luciene Cristina Figueiredo, Tatiane Tiemi Macedo, Lucas Daylor Aguiar da Silva, Helio Chagas Chaves de Oliveira Junior, Carlos Roberto Polaquini, Luís Octávio Regasini, and Janaina de Cássia Orlandi Sardi. 2025. "An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms" Future Pharmacology 5, no. 2: 19. https://doi.org/10.3390/futurepharmacol5020019
APA StyleAires da Silva, V. A., Bueno-Silva, B., Figueiredo, L. C., Tiemi Macedo, T., Aguiar da Silva, L. D., Chagas Chaves de Oliveira Junior, H., Polaquini, C. R., Regasini, L. O., & Sardi, J. d. C. O. (2025). An In Vitro Diacetylcurcumin Study for Periodontitis: A New Approach to Controlling Subgingival Biofilms. Future Pharmacology, 5(2), 19. https://doi.org/10.3390/futurepharmacol5020019