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Review

A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)

by
Viren Soni
1,*,
Akhil Nagar
2,*,
Ruchita Bardiya
2,
Jacob Mara
1,
Lukas Von Suskil
1,
Sabrina Rose
1 and
Chetankumar Sonawane
3
1
Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
2
Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra, India
3
Shri Vile Parle Kelavani Mandal, Institute of Pharmacy, Dhule 424001, Maharashtra, India
*
Authors to whom correspondence should be addressed.
Int. J. Transl. Med. 2023, 3(2), 217-245; https://doi.org/10.3390/ijtm3020016
Submission received: 21 February 2023 / Revised: 19 April 2023 / Accepted: 27 April 2023 / Published: 5 May 2023
(This article belongs to the Special Issue Trends of Translational Medicine for Oncology)
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Abstract

Cancer stem cells (CSCs) are the cells in a primary tumor that have the opportunity to self-renew as well as differentiate into certain cell types, thus forming a mixed tumor. CSCs have been shown to be involved in every aspect of cancer development, including tumor initiation, proliferation, and metastatic activity; they are also involved in chemotherapeutic drug resistance and the recurrence of certain cancers. Based on these capabilities, CSCs have been explored as the next target for the treatment and management of cancer. Salinomycin (SAL), a polyether ionophore antibiotic being used in the poultry industry, was identified as a powerful anti-cancer compound that possesses broad-spectrum activities, especially against CSCs. Here we point out the noteworthy work reported on SAL’s mechanism of action, anticancer activities, toxicity, and clinic applications. In addition, SAL derivatives synthesized by different research groups and their biological activity will also be highlighted.
Keywords: cancer stem cells; salinomycin; ironomycin; triple negative breast cancer; chemotherapeutic agents cancer stem cells; salinomycin; ironomycin; triple negative breast cancer; chemotherapeutic agents

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MDPI and ACS Style

Soni, V.; Nagar, A.; Bardiya, R.; Mara, J.; Von Suskil, L.; Rose, S.; Sonawane, C. A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022). Int. J. Transl. Med. 2023, 3, 217-245. https://doi.org/10.3390/ijtm3020016

AMA Style

Soni V, Nagar A, Bardiya R, Mara J, Von Suskil L, Rose S, Sonawane C. A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022). International Journal of Translational Medicine. 2023; 3(2):217-245. https://doi.org/10.3390/ijtm3020016

Chicago/Turabian Style

Soni, Viren, Akhil Nagar, Ruchita Bardiya, Jacob Mara, Lukas Von Suskil, Sabrina Rose, and Chetankumar Sonawane. 2023. "A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022)" International Journal of Translational Medicine 3, no. 2: 217-245. https://doi.org/10.3390/ijtm3020016

APA Style

Soni, V., Nagar, A., Bardiya, R., Mara, J., Von Suskil, L., Rose, S., & Sonawane, C. (2023). A Concise Review of Prodigious Salinomycin and Its Derivatives Effective in Treatment of Breast Cancer: (2012–2022). International Journal of Translational Medicine, 3(2), 217-245. https://doi.org/10.3390/ijtm3020016

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