Solid Lipid Nanoparticles
Definition
:1. Introduction
2. Features of SLNs
2.1. Structural Features and General Components of SLNs
Ingredient | Examples | References |
---|---|---|
Solid lipid | Glyceryl palmitostearate (Precirol®® ATO 5) | [37,38,39] |
Glyceryl behenate (Compritol®® 888 ATO) | [37,40] | |
Stearic acid | [41] | |
Palmitic acid | [42] | |
Tristearin | [39,43,44] | |
Tripalmitin (Dynasan®® 116) | [45] | |
Trimyristin (Dynasan®® 114) | [20] | |
Cetyl palmitate | [46] | |
Cholesterol | [47] | |
Triolein | [44] | |
Tricaprylin | [44] | |
Liquid lipid | MCT (Miglyol®® 812) | [37,48] |
Propylene glycol dicaprylocaprate (Labrafac®®) | [40] | |
Caprylocaproyl Polyoxyl-8 glycerides (Labrasol®®) | [38] | |
Propylene glycol monocaprylate (Capryol™ 90) | [39] | |
Isopropyl myristate | [39] | |
Oleic acid | [42,43,44] | |
Squalene | [49,50] | |
α-tocopherol | [51] | |
Emulsifier | Poloxamer 188 | [37,40,47,50] |
Poloxamer 407 | [39] | |
Soybean lecithin, phosphatidylcholine | [20,43] | |
Polysorbate 80 | [20,42,43] | |
Polysorbate 60 | [44] | |
PEG-40 castor oil (Cremophor®® RH40) | [38] | |
Sodium deoxycholate | [51] | |
Sodium dodecyl sulfate | [41] |
2.2. Physicochemical Characterization
2.2.1. Particle Size and Polydispersity Index
2.2.2. Zeta Potential
2.2.3. Entrapment Efficiency
2.2.4. Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD)
2.2.5. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM)
2.3. Drug Incorporation Models and Drug Release
2.4. Stability and Safety
3. Methods for SLNs Preparation
3.1. Solvent-Based Methods
3.1.1. Solvent Emulsification-Evaporation Method
3.1.2. Solvent Emulsification-Diffusion Method
3.1.3. Solvent Injection Method
3.2. Non-Solvent Methods
3.2.1. High-Pressure Homogenization Method
3.2.2. High-Speed Stirring and Ultra-Sonication Methods
3.2.3. Microemulsion Method
3.2.4. Phase Inversion Temperature (PIT) Method
3.2.5. Membrane Contactor Method
3.2.6. Coacervation Method
3.3. Other Methods
3.3.1. Double Emulsion Method
3.3.2. Supercritical-Fluid-Based Methods
4. Recent Applications of SLNs in Drug Delivery
4.1. Oral Delivery
4.2. Parenteral Delivery
4.3. Transdermal Delivery
4.4. Intranasal Delivery
4.5. Ocular Delivery
4.6. Pulmonary Delivery
4.7. Clinical Application State
5. Conclusions and Prospects
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Parameters | Characterization | References |
---|---|---|
Particle size | Dynamic light scattering and laser diffraction | [52] |
Polydispersit index | Dynamic light scattering and laser diffraction | [52] |
Zeta potential | Dynamic light scattering | [58,59] |
Entrapment efficiency | Gel filtration chromatography | [63] |
Dialysis | [64] | |
Ultracentrifugation | [65,66] | |
Filter membrane | [67] | |
Crystallinity | Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) | [35] |
Shape and morphology | Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM) | [52,55,70,71] |
Method | Features | References |
---|---|---|
Solvent emulsification-evaporation | Suitable for highly thermo-labile drugs, no high temperatures and physical stress Toxic organic solvent removal | [91,92,93,94,95] |
Solvent emulsification-diffusion | Suitable for highly thermo-labile drugs, does not require high temperatures and physical stress Toxic organic solvent removal, high water amount, and low SLN concentration | [101,102,103,104] |
Solvent injection | Simple, fast production, no complicated instruments Toxic organic solvent removal | [67,108,109,110] |
Hot high-pressure homogenization | Organic-solvent-free operation, short production time, and scale-up feasibility Unsuitable for heat-sensitive or hydrophilic drugs | [120,121,122,123,124] |
Cold high-pressure homogenization | Suitable for water-soluble drugs to prevent drug loss Large particles and laborious processes | [126,129,130] |
High-speed stirring and ultra-sonication | Organic-solvent-free operation and ease of implementation High surfactant amounts, exposal of drugs to high temperatures, and metal contamination | [138,139,140,141,142,143] |
Microemulsion | Simple, reproducible, solvent-free, and feasible to scale up Large amount of surfactant and water | [149,150,151,152] |
Phase inversion temperature | Based on non-ionic polyoxyethylated surfactants Solvent-free, little energy input Low stability of the nanoemulsion | [158,159,160] |
Membrane contactor | Use of a specific membrane contactor Scale-up feasibility and particle-size controllability Sophisticated system and clogging risk of the membrane | [164] |
Coacervation | Use of alkaline salts of fatty acids Straightforward and solvent-free Unsuitable for pH-sensitive drugs, only applicable to alkaline salt lipids | [168,169] |
Double emulsion | Preparation of a water/oi/water double emulsion Suitable for hydrophilic drugs High drug loss and large particle size | [172,173,177,178] |
Supercritical fluid | Uniform-particle-size distributions and high solvent-extraction efficiencies Use of organic solvents and expensive supercritical fluids | [180,183] |
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Nguyen, T.-T.-L.; Duong, V.-A. Solid Lipid Nanoparticles. Encyclopedia 2022, 2, 952-973. https://doi.org/10.3390/encyclopedia2020063
Nguyen T-T-L, Duong V-A. Solid Lipid Nanoparticles. Encyclopedia. 2022; 2(2):952-973. https://doi.org/10.3390/encyclopedia2020063
Chicago/Turabian StyleNguyen, Thi-Thao-Linh, and Van-An Duong. 2022. "Solid Lipid Nanoparticles" Encyclopedia 2, no. 2: 952-973. https://doi.org/10.3390/encyclopedia2020063
APA StyleNguyen, T.-T.-L., & Duong, V.-A. (2022). Solid Lipid Nanoparticles. Encyclopedia, 2(2), 952-973. https://doi.org/10.3390/encyclopedia2020063