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Kidney and Dialysis
Volume 2
Issue 4
10.3390/kidneydial2040055
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Review

Cell–Matrix Interactions in Renal Fibrosis

by
Kristin P. Kim
,
Caitlin E. Williams
and
Christopher A. Lemmon
*
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
*
Author to whom correspondence should be addressed.
Kidney Dial. 2022, 2(4), 607-624; https://doi.org/10.3390/kidneydial2040055
Submission received: 20 September 2022 / Revised: 17 November 2022 / Accepted: 2 December 2022 / Published: 7 December 2022
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Abstract

Renal fibrosis is a hallmark of end-stage chronic kidney disease. It is characterized by increased accumulation of extracellular matrix (ECM), which disrupts cellular organization and function within the kidney. Here, we review the bi-directional interactions between cells and the ECM that drive renal fibrosis. We will discuss the cells involved in renal fibrosis, changes that occur in the ECM, the interactions between renal cells and the surrounding fibrotic microenvironment, and signal transduction pathways that are misregulated as fibrosis proceeds. Understanding the underlying mechanisms of cell–ECM crosstalk will identify novel targets to better identify and treat renal fibrosis and associated renal disease.
Keywords: renal fibrosis; extracellular matrix; cell–matrix interactions; cell signaling pathways; fibronectin; collagen; fibroblasts; epithelial cells renal fibrosis; extracellular matrix; cell–matrix interactions; cell signaling pathways; fibronectin; collagen; fibroblasts; epithelial cells

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MDPI and ACS Style

Kim, K.P.; Williams, C.E.; Lemmon, C.A. Cell–Matrix Interactions in Renal Fibrosis. Kidney Dial. 2022, 2, 607-624. https://doi.org/10.3390/kidneydial2040055

AMA Style

Kim KP, Williams CE, Lemmon CA. Cell–Matrix Interactions in Renal Fibrosis. Kidney and Dialysis. 2022; 2(4):607-624. https://doi.org/10.3390/kidneydial2040055

Chicago/Turabian Style

Kim, Kristin P., Caitlin E. Williams, and Christopher A. Lemmon. 2022. "Cell–Matrix Interactions in Renal Fibrosis" Kidney and Dialysis 2, no. 4: 607-624. https://doi.org/10.3390/kidneydial2040055

APA Style

Kim, K. P., Williams, C. E., & Lemmon, C. A. (2022). Cell–Matrix Interactions in Renal Fibrosis. Kidney and Dialysis, 2(4), 607-624. https://doi.org/10.3390/kidneydial2040055

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