Exploring the Feasibility of Intrapartum GBS Collection to Identify Residual GBS in a Pilot Study of an Antenatal Probiotic Intervention
Abstract
:1. Introduction
2. Materials and Methods
2.1. Relationship of the Pilot Sub-Study to Parent Double-Blind, Placebo-Controlled RCT
2.2. Data Collection
2.3. Statistical Analysis
3. Results
4. Discussion
4.1. Limitations
4.2. Clinical Implications
4.3. Feasibility
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Total | Probiotics (n = 14) | Placebo (n = 16) | p Value |
---|---|---|---|---|
Age (Mean, SD) | 29.87 ± 5.46 | 30.0 ± 5.31 | 29.75 ± 5.77 | 0.9029 |
Race (N, %) | 0.6237 | |||
Black | 10 (33.33) | 4 (28.57) | 6 (37.5) | |
White | 18 (60.0) | 10 (71.43) | 8 (50.0) | |
Asian | 1 (3.33) | 0 (0.0) | 1 (6.25) | |
Other | 1 (3.33) | 0 (0.0) | 1 (6.25) | |
Parity | 0.3625 | |||
Multiparous | 17 (56.67) | 7 (50.0) | 10 (62.5) | |
Nulliparous | 12 (4.80) * 1 missing | 7 (50.0) | 5 (31.25) | |
Apgar Scores, (Mean, SD) | ||||
1 min | 7.33 ± 1.40 | 7.43 ±1.16 | 7.25 ±1.61 | 0.7336 |
5 min | 8.77 ± 0.68 | 8.79 ± 0.58 | 8.75 ± 0.78 | 0.8886 |
Mode of birth | 0.4171 | |||
Vaginal | 22 (73.33) | 9 (64.29) | 13 (81.25) | |
Cesarean | 8 (26.67) | 5 (35.71) | 3 (18.75) | |
Newborn birth weight (Mean, SD), grams | 3361.10 ± 271.70 | 3386.30 ± 293.90 | 3339.10 ± 258.40 | 0.6431 |
GBS Timing | Total (n = 30) | Probiotics (n = 14) | Placebo (n = 16) | p Value |
---|---|---|---|---|
36-week SOC (n, %) | ||||
Positive | 8 (26.67) | 3 (21.43) | 5 (31.25) | 0.6887 |
Negative | 22 (73.33) | 11 (78.57) | 11 (68.75) | |
Intrapartum (n, %) | ||||
Positive | * 6 (20.0) | 3 (21.43) | * 3 (18.75) | 0.639 |
Negative | 23 (76.67) | 11 (78.57) | 12 (75) | |
Rate of change (n, %) | ||||
No group change | 26 (86.67) | 12 (85.7) | 14 (87.5) | 0.8859 |
Group change | 4 (13.33) | 2 (12.5) | 2 (14.29) | |
• Pos to Neg | 3 | 1 | 2 | |
• Neg to Pos | 1 | 1 | 0 |
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Malloy, E.; Hanson, L.; VandeVusse, L.; Robinson, K.; Singh, M.; Forgie, M. Exploring the Feasibility of Intrapartum GBS Collection to Identify Residual GBS in a Pilot Study of an Antenatal Probiotic Intervention. Appl. Microbiol. 2023, 3, 752-763. https://doi.org/10.3390/applmicrobiol3030052
Malloy E, Hanson L, VandeVusse L, Robinson K, Singh M, Forgie M. Exploring the Feasibility of Intrapartum GBS Collection to Identify Residual GBS in a Pilot Study of an Antenatal Probiotic Intervention. Applied Microbiology. 2023; 3(3):752-763. https://doi.org/10.3390/applmicrobiol3030052
Chicago/Turabian StyleMalloy, Emily, Lisa Hanson, Leona VandeVusse, Karen Robinson, Maharaj Singh, and Marie Forgie. 2023. "Exploring the Feasibility of Intrapartum GBS Collection to Identify Residual GBS in a Pilot Study of an Antenatal Probiotic Intervention" Applied Microbiology 3, no. 3: 752-763. https://doi.org/10.3390/applmicrobiol3030052