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Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review

1
Faculty of Science and Technology, Universidade do Algarve, 8005-139 Faro, Portugal
2
Centro de Ciências do Mar (CCMar), Universidade do Algarve, 8005-139 Faro, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Buyong Ma
BioChem 2022, 2(2), 145-159; https://doi.org/10.3390/biochem2020010
Received: 31 December 2021 / Revised: 4 May 2022 / Accepted: 12 May 2022 / Published: 14 May 2022
(This article belongs to the Special Issue Selected Papers from XXI SPB National Congress of Biochemistry 2021)
In this contribution, we provide an overview of gold compound applications against viruses or parasites during recent years. The special properties of gold have been the subject of intense investigation in recent years, which has led to the development of its chemistry with the synthesis of new compounds and the study of its applicability in various areas such as catalysis, materials, nanotechnology and medicine. Herein, thirteen gold articles with applications in several viruses, such as hepatitis C virus (HCV), influenza A virus (H1N1), vesicular stomatitis virus (VSV), coronavirus (SARS-CoV and SARS-CoV-2), Dengue virus, and several parasites such as Plasmodium sp., Leishmania sp., Tripanossoma sp., Brugia sp., Schistosoma sp., Onchocerca sp., Acanthamoeba sp., and Trichomonas sp. are described. Gold compounds with anti-viral activity include gold nanoparticles with the ligands mercaptoundecanosulfonate, 1-octanethiol and aldoses and gold complexes with phosphine and carbene ligands. All of the gold compounds with anti-parasitic activity reported are gold complexes of the carbene type. Auranofin is a gold drug already used against rheumatoid arthritis, and it has also been tested against virus and parasites. View Full-Text
Keywords: gold nanoparticles; gold complexes; auranofin; biological targets; virus; parasites gold nanoparticles; gold complexes; auranofin; biological targets; virus; parasites
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MDPI and ACS Style

Fonseca, C.; Aureliano, M. Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review. BioChem 2022, 2, 145-159. https://doi.org/10.3390/biochem2020010

AMA Style

Fonseca C, Aureliano M. Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review. BioChem. 2022; 2(2):145-159. https://doi.org/10.3390/biochem2020010

Chicago/Turabian Style

Fonseca, Custódia, and Manuel Aureliano. 2022. "Biological Activity of Gold Compounds against Viruses and Parasitosis: A Systematic Review" BioChem 2, no. 2: 145-159. https://doi.org/10.3390/biochem2020010

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