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Review

Recognizing and Managing Skin Integrity Issues in Compromised Aging Skin: The Importance of Gentle Skin Cleansing, Adequate Moisturization, and Skin Barrier Protection

Department of Scientific Affairs, Ego Pharmaceuticals Pty Ltd., 21–31 Malcolm Road, Braeside, VIC 3195, Australia
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Author to whom correspondence should be addressed.
Dermato 2026, 6(2), 16; https://doi.org/10.3390/dermato6020016
Submission received: 28 January 2026 / Revised: 20 March 2026 / Accepted: 27 April 2026 / Published: 1 May 2026
(This article belongs to the Special Issue Reviews in Dermatology: Current Advances and Future Directions)

Abstract

The skin serves as a primary defensive barrier to protect the body from environmental contaminants, infections and trauma. Unfortunately, skin barrier’s structural and functional integrity can be compromised, disrupted or impaired due to a combination of internal and external factors, making it vulnerable and often leading to a wide range of skin conditions characterized by dryness, heightened sensitivity, and increased susceptibility to damage and infections. In addition, the integrity of the skin barrier tends to deteriorate progressively with age. As people age, their skin naturally changes and can also be compromised by a plethora of factors that reduce its strength and resilience. The aging skin becomes thinner and more sensitive, coinciding with a variety of structural–functional alterations, decreased levels of natural moisturizing factor (NMF), lipid content and hydration, increased transepidermal water loss (TEWL), altered skin surface pH (pHss) and microbiome diversity. All these age-related skin integrity alterations make the skin drier, flakier, itchy, and fragile, and more susceptible to damage and breakdown, thus diminishing its ability to effectively protect, repair and heal efficiently. Identifying skin integrity issues before they progress will foster positive outcomes through effective preventive measures. Hence, it is important to understand the impact of skincare formulations on skin integrity in compromised aging skin. A well-considered, evidence-based approach to skincare can provide cleansing, moisturizing and protective benefits, while aiding the reduction in skin integrity issues like dry and itchy skin, sensitive skin, bruising, skin tears, pressure injuries (PIs), lower leg ulcers and moisture-associated skin damage (MASD). Managing skin integrity in compromised aging skin begins with gentle skin cleansing, adequate moisturization and protective barrier care to ensure the skin’s function is maximized.
Keywords: aging skin; compromised skin barrier; corneocytes; dry skin; gentle cleanser; lipids; moisturizer; skin barrier alterations; skin hydration; skin protection; skin tear aging skin; compromised skin barrier; corneocytes; dry skin; gentle cleanser; lipids; moisturizer; skin barrier alterations; skin hydration; skin protection; skin tear

Share and Cite

MDPI and ACS Style

Mijaljica, D.; Townley, J.P.; Torpy, K.; Meere, S.; Spada, F.; Lai, M. Recognizing and Managing Skin Integrity Issues in Compromised Aging Skin: The Importance of Gentle Skin Cleansing, Adequate Moisturization, and Skin Barrier Protection. Dermato 2026, 6, 16. https://doi.org/10.3390/dermato6020016

AMA Style

Mijaljica D, Townley JP, Torpy K, Meere S, Spada F, Lai M. Recognizing and Managing Skin Integrity Issues in Compromised Aging Skin: The Importance of Gentle Skin Cleansing, Adequate Moisturization, and Skin Barrier Protection. Dermato. 2026; 6(2):16. https://doi.org/10.3390/dermato6020016

Chicago/Turabian Style

Mijaljica, Dalibor, Joshua P. Townley, Kira Torpy, Sharon Meere, Fabrizio Spada, and Mikayla Lai. 2026. "Recognizing and Managing Skin Integrity Issues in Compromised Aging Skin: The Importance of Gentle Skin Cleansing, Adequate Moisturization, and Skin Barrier Protection" Dermato 6, no. 2: 16. https://doi.org/10.3390/dermato6020016

APA Style

Mijaljica, D., Townley, J. P., Torpy, K., Meere, S., Spada, F., & Lai, M. (2026). Recognizing and Managing Skin Integrity Issues in Compromised Aging Skin: The Importance of Gentle Skin Cleansing, Adequate Moisturization, and Skin Barrier Protection. Dermato, 6(2), 16. https://doi.org/10.3390/dermato6020016

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