Dosimetric Parameters Predicting Tooth Loss after Carbon Ion Radiotherapy for Head and Neck Tumors
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Patients
2.2. CIRT
2.3. Assessment of Tooth Loss
2.4. Dose–Volume Analysis of the Teeth
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Incidence of Tooth Loss Post-CIRT
3.3. Dose–Volume Analysis of Tooth Loss Post-CIRT
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | All (n = 14) | ||
---|---|---|---|
Age | |||
Median (range) | 59 (32–77) | ||
Gender | |||
Male | 5 | ||
Female | 9 | ||
Performance status | |||
0 | 6 | ||
1 | 8 | ||
Histology | |||
Adenoid cystic carcinoma | 10 | ||
Mucoepidermoid carcinoma | 2 | ||
Olfactory neuroblastoma | 1 | ||
Basal cell adenocarcinoma | 1 | ||
Primary tumor site | |||
Nasal cavity | 7 | ||
Maxillary sinus | 3 | ||
Oral cavity | 2 | ||
Pharynx | 1 | ||
Parotid gland | 1 | ||
Operability | |||
Operable | 8 | ||
Inoperable | 6 | ||
Primary or recurrence | |||
Primary tumor | 12 | ||
Postoperative recurrence | 2 | ||
T stage | |||
T2 | 2 | ||
T3 | 6 | ||
T4 | 6 | ||
N stage | |||
N0 | 14 | ||
Carbon-ion dose | |||
64.0 Gy (RBE)/16 fractions | 13 | ||
57.6 Gy (RBE)/16 fractions | 1 |
Parameter | V10 | V20 | V30 | V40 | V50 | V60 |
---|---|---|---|---|---|---|
Cut-off value | 99.9% | 99.1% | 97.8% | 78.1% | 58.1% | 7.67% |
Sensitivity | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Specificity | 0.66 | 0.86 | 0.92 | 0.92 | 0.94 | 0.93 |
Accuracy | 0.71 | 0.88 | 0.94 | 0.94 | 0.95 | 0.94 |
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Kubo, N.; Sakai, M.; Kawamura, H.; Oike, T.; Kubota, Y.; Anakura, M.; Adachi, A.; Sato, H.; Musha, A.; Okano, N.; et al. Dosimetric Parameters Predicting Tooth Loss after Carbon Ion Radiotherapy for Head and Neck Tumors. Radiation 2021, 1, 183-193. https://doi.org/10.3390/radiation1030017
Kubo N, Sakai M, Kawamura H, Oike T, Kubota Y, Anakura M, Adachi A, Sato H, Musha A, Okano N, et al. Dosimetric Parameters Predicting Tooth Loss after Carbon Ion Radiotherapy for Head and Neck Tumors. Radiation. 2021; 1(3):183-193. https://doi.org/10.3390/radiation1030017
Chicago/Turabian StyleKubo, Nobuteru, Makoto Sakai, Hidemasa Kawamura, Takahiro Oike, Yoshiki Kubota, Mai Anakura, Akiko Adachi, Hiro Sato, Atsushi Musha, Naoko Okano, and et al. 2021. "Dosimetric Parameters Predicting Tooth Loss after Carbon Ion Radiotherapy for Head and Neck Tumors" Radiation 1, no. 3: 183-193. https://doi.org/10.3390/radiation1030017