Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility
Abstract
:1. Introduction
2. Materials and Methods
2.1. Analysis of RYK Expression in Cancer-Derived RNA Data Sets
2.2. RYK Expression in Cancer Subtypes RNA Data Sets
2.3. Protein Expression Analysis
2.4. Survival Analysis
2.5. Correlation and Expression of WNT Pathway Receptors and Ligands
2.6. Expression and Relation of RYK with Cancer-Related Pathways
3. Results
3.1. RYK Overexpression in Cancer
3.2. Overexpression of Receptor-like Tyrosine Kinase in Cancer- and Non-Cancer-Derived Tissues
3.3. Prognostic Value of RYK in Cancer
3.4. Correlation of the WNT Signaling Pathway Receptors and Ligands with RYK Expression in Cancer- and Non-Cancer-Derived Samples
3.5. Association of RYK with Ten Cancer-Related Signaling Pathways
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zapata-García, J.A.; Jave-Suárez, L.F.; Aguilar-Lemarroy, A. Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility. J. Mol. Pathol. 2024, 5, 66-80. https://doi.org/10.3390/jmp5010005
Zapata-García JA, Jave-Suárez LF, Aguilar-Lemarroy A. Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility. Journal of Molecular Pathology. 2024; 5(1):66-80. https://doi.org/10.3390/jmp5010005
Chicago/Turabian StyleZapata-García, Jessica Alejandra, Luis Felipe Jave-Suárez, and Adriana Aguilar-Lemarroy. 2024. "Delving into the Role of Receptor-like Tyrosine Kinase (RYK) in Cancer: In Silico Insights into Its Diagnostic and Prognostic Utility" Journal of Molecular Pathology 5, no. 1: 66-80. https://doi.org/10.3390/jmp5010005