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Journal of Molecular Pathology, Volume 4, Issue 2

June 2023 - 5 articles

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Articles (5)

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Article

11 Citations

10,365 Views

19 Pages

Analytical Validation and Clinical Utilization of the Oncomine Comprehensive Assay Plus Panel for Comprehensive Genomic Profiling in Solid Tumors

Catherine I. Dumur,
Ramakrishnan Krishnan,
Jorge A. Almenara,
Kathleen E. Brown,
Kailyn R. Dugan,
Christiana Farni,
Fatima Z. Ibrahim,
Naomi A. Sanchez,
Sumra Rathore and
Dinesh Pradhan
+ 1 author

J. Mol. Pathol.2023, 4(2), 109-127;https://doi.org/10.3390/jmp4020012

7 June 2023

The detection of driver oncogenic variants and the recent identification of tumor-agnostic genomic biomarkers has driven the use of comprehensive genomic profiling (CGP) for disease diagnosis, prognosis, and treatment selection. The Oncomine™ C...

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Review

31 Citations

21,762 Views

10 Pages

Different Subtypes of Osteosarcoma: Histopathological Patterns and Clinical Behaviour

Emel Rothzerg,
Jiake Xu and
David Wood

J. Mol. Pathol.2023, 4(2), 99-108;https://doi.org/10.3390/jmp4020011

16 May 2023

Osteosarcoma (OS) is a primary malignant bone tumour that usually occurs in children and adolescents. OS is a highly aggressive tumour type with a propensity for local invasion and systemic early metastasis to the lungs or other bones. According to t...

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Article

2 Citations

2,947 Views

10 Pages

Sinonasal Hyalinizing Adenoid Cystic Carcinoma Is Molecularly Different from Its Salivary and Breast Counterparts

Ebtissam Alerraqi,
Essam Mandour and
Mariz Faltas

J. Mol. Pathol.2023, 4(2), 89-98;https://doi.org/10.3390/jmp4020010

15 May 2023

Adenoid cystic carcinoma (AdCC) is known to behave differently based on its location, histologic features, and molecular profile. Despite this understanding, efforts to use these molecular findings to develop personalized treatments have not yet been...

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Opinion

3,420 Views

8 Pages

Liquid Biopsy in EGFR-Mutated Advanced NSCLC from T790M to MET Amplification: Clinical Implications and Possibilities in the Resistance Setting

Luigi Della Gravara,
Ciro Battiloro,
Aniello Avellino,
Francesca Caputo,
Carmine D’Aniello and
Danilo Rocco

J. Mol. Pathol.2023, 4(2), 81-88;https://doi.org/10.3390/jmp4020009

30 April 2023

According to the ESMO and ASCO clinical guidelines, the main role of liquid biopsy in EGFR+ advanced NSCLC patients is represented by T790M detection after erlotinib/gefitinib/afatinib progression. However, the general international expert consensus...

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Article

9 Citations

5,686 Views

12 Pages

Performance of a 7-Type HPV mRNA Test in Triage of HPV DNA Primary Screen Positive Women Compared to Liquid-Based Cytology

Sveinung Wergeland Sørbye,
Bente Marie Falang and
Mona Antonsen

J. Mol. Pathol.2023, 4(2), 69-80;https://doi.org/10.3390/jmp4020008

25 March 2023

Background: A plethora of data supports HPV-based screening to be the preferred strategy for cervical cancer prevention. The shift to a more sensitive first-line test brings the need of effective triage up for discussion. Currently, most algorithms a...

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