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Volume 59
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Proceeding Paper

Synthesis of Fused Isoxazoles: A Comprehensive Review †

by
Niveditha N. Mallik
1,
Chandramouli Manasa
1,
Vrushabendra Basavanna
1,
Dileep C. Shanthakumar
2,
Srikantamurthy Ningaiah
1 and
Nagarakere S. Lingegowda
1,*
1
Department of Chemistry, Vidyavardhaka College of Engineering, Visvesvaraya Technological University, Mysore 570 002, Karnataka, India
2
Department of Physics, Vidyavardhaka College of Engineering, Visvesvaraya Technological University, Mysore 570 002, Karnataka, India
*
Author to whom correspondence should be addressed.
†
Presented at the International Conference on Recent Advances on Science and Engineering, Dubai, United Arab Emirates, 4–5 October 2023.
Eng. Proc. 2023, 59(1), 222; https://doi.org/10.3390/engproc2023059222
Published: 30 January 2024
(This article belongs to the Proceedings of Eng. Proc., 2023, RAiSE-2023)
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Abstract

Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs. Many significant properties are exhibited by synthetically modified isoxazoles. Fused isoxazoles have widely shown their therapeutic potential as anticancer, insecticidal, antibacterial, antituberculosis, antifungal, antibiotic, antitumor, and antiulcerogenic agents. A variety of strategies are employed for the synthesis of these compounds, which are known for their pharmacological importance. Their synthesis is here reviewed. Synthesized isoxazoles have appeared as good forerunners for many other different molecules. This review summarizes the various synthesis approaches described so far for isoxazoles, providing a detailed study of their synthesis process. Substituted isoxazoles have been well discussed in the literature for their significant biological activities. This review is mainly focused on the synthesis of fused isoxazoles.
Keywords: isoxazoles; fused isoxazole; hydroxylamine hydrochloride isoxazoles; fused isoxazole; hydroxylamine hydrochloride

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MDPI and ACS Style

Mallik, N.N.; Manasa, C.; Basavanna, V.; Shanthakumar, D.C.; Ningaiah, S.; Lingegowda, N.S. Synthesis of Fused Isoxazoles: A Comprehensive Review. Eng. Proc. 2023, 59, 222. https://doi.org/10.3390/engproc2023059222

AMA Style

Mallik NN, Manasa C, Basavanna V, Shanthakumar DC, Ningaiah S, Lingegowda NS. Synthesis of Fused Isoxazoles: A Comprehensive Review. Engineering Proceedings. 2023; 59(1):222. https://doi.org/10.3390/engproc2023059222

Chicago/Turabian Style

Mallik, Niveditha N., Chandramouli Manasa, Vrushabendra Basavanna, Dileep C. Shanthakumar, Srikantamurthy Ningaiah, and Nagarakere S. Lingegowda. 2023. "Synthesis of Fused Isoxazoles: A Comprehensive Review" Engineering Proceedings 59, no. 1: 222. https://doi.org/10.3390/engproc2023059222

APA Style

Mallik, N. N., Manasa, C., Basavanna, V., Shanthakumar, D. C., Ningaiah, S., & Lingegowda, N. S. (2023). Synthesis of Fused Isoxazoles: A Comprehensive Review. Engineering Proceedings, 59(1), 222. https://doi.org/10.3390/engproc2023059222

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