Perspectives on Synthetic Adducts (Salts) of NitroxolineTM and 2-Aminoquinolin-8-ol as Promising Antibacterial Agents †
Abstract
:1. Introduction
2. Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Code | Compound | Structure |
---|---|---|
NQ | NitroxolineTM | |
NQs1 | NitroxolineTM, natrium salt | |
NQs2 | NitroxolineTM salt with 4-benzylamine | |
NQs3 | NitroxolineTM salt with, 4-(aminomethyl)pyridine | |
2A8OHQ | 2-Amino-8-hydroxyquinoline | |
2A8OHQs1 | 2-Amino-8-hydroxyquinoline salt with oxalic acid | |
2A8OHQs2 | 2-Amino-8-hydroxyquinoline salt with 2,3-pyrazinedicarboxylic acid | |
2A8OHQs3 | 2-Amino-8-hydroxyquinoline salt with chelidonic acid | |
2A8OHQs4 | 2-Amino-8-hydroxyquinoline salt with quinalid acid | |
2A8OHQs5 | 2-Amino-8-hydroxyquinoline salt with 3,5-dinitrosalicylic acid | |
2A8OHQs6 | 2-Amino-8-hydroxyquinoline salt with quinoline-2-carboxylic acid | |
2A8OHQs7 | 2-Amino-8-hydroxyquinoline salt with quinoline-3-carboxylic acid | |
2A8OHQs8 | 2-Amino-8-hydroxyquinoline salt with xanthurenic acid | |
2A8OHQs9 | 2-Amino-8-hydroxyquinoline salt with kynurenic acid |
Strain No./ Compound Code | MIC (mg/L) | |||||||
---|---|---|---|---|---|---|---|---|
4498 | 3541 | 500 | 3396 | 3333 | 636 | 1942 | 4352 | |
NQ | 32 | 16 | 16 | 16 | 8 | 16 | 8 | 32 |
NQs1 | 8 | 8 | 12 | 32 | 4 | 8 | 4 | 12 |
NQs2 | 16 | 16 | 8 | 32 | 8 | 8 | 4 | 8 |
NQs3 | 32 | 8 | 8 | 32 | 8 | 8 | 4 | 8 |
2A8OHQ | 64 | 64 | 32 | 64 | 32 | 16 | 64 | 64 |
2A8OHQs1 | 64 | 32 | 32 | 64 | 32 | 16 | 32 | 64 |
2A8OHQs2 | 32 | 32 | 32 | 64 | 32 | 16 | 32 | 64 |
2A8OHQs3 | 64 | 32 | 32 | 64 | 32 | 8 | 32 | 64 |
2A8OHQs4 | 32 | 32 | 32 | 64 | 32 | 8 | 32 | 64 |
2A8OHQs5 | 32 | 32 | 32 | 32 | 32 | 16 | 32 | 64 |
2A8OHQs6 | 64 | 32 | 32 | 64 | 32 | 16 | 32 | 64 |
2A8OHQs7 | 64 | 32 | 32 | 64 | 32 | 4 | 16 | 64 |
2A8OHQs8 | 32 | 32 | 32 | 64 | 32 | 16 | 32 | 64 |
2A8OHQs9 | 64 | 32 | 32 | 64 | 32 | 4 | 16 | 64 |
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Maliar, T.; Gašparová, R.; Maliarová, M. Perspectives on Synthetic Adducts (Salts) of NitroxolineTM and 2-Aminoquinolin-8-ol as Promising Antibacterial Agents. Chem. Proc. 2024, 16, 92. https://doi.org/10.3390/ecsoc-28-20260
Maliar T, Gašparová R, Maliarová M. Perspectives on Synthetic Adducts (Salts) of NitroxolineTM and 2-Aminoquinolin-8-ol as Promising Antibacterial Agents. Chemistry Proceedings. 2024; 16(1):92. https://doi.org/10.3390/ecsoc-28-20260
Chicago/Turabian StyleMaliar, Tibor, Renata Gašparová, and Mária Maliarová. 2024. "Perspectives on Synthetic Adducts (Salts) of NitroxolineTM and 2-Aminoquinolin-8-ol as Promising Antibacterial Agents" Chemistry Proceedings 16, no. 1: 92. https://doi.org/10.3390/ecsoc-28-20260
APA StyleMaliar, T., Gašparová, R., & Maliarová, M. (2024). Perspectives on Synthetic Adducts (Salts) of NitroxolineTM and 2-Aminoquinolin-8-ol as Promising Antibacterial Agents. Chemistry Proceedings, 16(1), 92. https://doi.org/10.3390/ecsoc-28-20260