Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature
Abstract
:1. Introduction
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
TGCTs | Testicular granulosa cell tumors |
AGCT | Adult granulosa cell tumor |
CT | Computed tomography |
LDH | Lactate dehydrogenase |
References
- Scully, R.E. Ovarian tumors. A review. Am. J. Pathol. 1977, 87, 686–720. [Google Scholar] [PubMed]
- Grogg, J.B.; Schneider, K.; Bode, P.-K.; Kranzbühler, B.; Eberli, D.; Sulser, T.; Beyer, J.; Lorch, A.; Hermanns, T.; Fankhauser, C.D. Risk factors and treatment outcomes of 239 patients with testicular granulosa cell tumors: A systematic review of published case series data. J. Cancer Res. Clin. Oncol. 2020, 146, 2829–2841. [Google Scholar] [CrossRef] [PubMed]
- Dieckmann, K.-P.; Bertolini, J.; Wülfing, C. Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature. Case Rep. Urol. 2019, 2019, 7156154. [Google Scholar] [CrossRef] [Green Version]
- Elbachiri, M.; Taleb, A.; Derrabi, N.; Bouchbika, Z.; Benchakroun, N.; Jouhadi, H.; Tawfiq, N.; Sahraoui, S.; Benider, A. Adult-type granulosa cell tumor of the testis: Report of a case and review of literature. Pan. Afr. Med. J. 2017, 26, 198. [Google Scholar] [CrossRef] [PubMed]
- Moch, H.; Humphrey, P.A.; Ulbright, T.M.; Reuter, V.E. (Eds.) WHO Classification of Tumours of the Urinary System and Male Genital Organs, 4th ed.; International Agency for Research on Cancer: Lyon, France, 2016; Volume 7, p. 335.
- Ulbright, T.M.; Amin, M.B.; Young, R.H. Tumors of the testis, adenexa, spermatic cord, and scrotum. In Atlas of Tumor Pathology, 3rd ed.; Rosai, J., Sobin, L.H., Eds.; Armed Forces Institute of Pathology: Washington, DC, USA, 1999. [Google Scholar]
- Young, R.H.; Lawrence, W.D.; Scully, R.E. Juvenile granulosa cell tumor-another neoplasm associated with abnormal chromosomes and ambiguous genitalia. A report of three cases. Am. J. Surg. Pathol. 1985, 9, 737–743. [Google Scholar]
- Shah, S.P.; Köbel, M.; Senz, J.; Morin, R.D.; Clarke, B.A.; Wiegand, K.C.; Leung, G.; Zayed, A.; Mehl, E.; Kalloger, S.E.; et al. Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary. N. Engl. J. Med. 2009, 360, 2719–2729. [Google Scholar] [CrossRef]
- Leung, D.T.H.; Fuller, P.J.; Chu, S. Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors. Int. J. Biochem. Cell Biol. 2016, 72, 51–54. [Google Scholar] [CrossRef]
- Laskowski, J. Feminizing tumours of testis; general review with case report of granulosa cell tumour of testis. Endokrynol. Pol. 1952, 3, 337–343. [Google Scholar]
- Cohen, J.; Diamond, J. Leontiasis ossea, slipped epiphyses and granulosa cell tumor of the testis with renal disease. Arch. Pathol. Lab. Med. 1953, 56, 488–500. [Google Scholar]
- Schubert, T.E.; Stoehr, R.; Hartmann, A.; Schöne, S.; Löbelenz, M.; Mikuz, G. Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: Case report and review of the literature. Diagn. Pathol. 2014, 9, 107. [Google Scholar] [CrossRef] [Green Version]
- Melicow, M. Classification of Tumors of Testis: A Clinical and Pathological Study Based on 105 Primary and 13 Secondary Cases in Adults, and 3 Primary and 4 Secondary Cases in Children. J. Urol. 1955, 73, 547–574. [Google Scholar] [CrossRef]
- Mostofi, F.K.; Theiss, E.A.; Ashley, D.J.B. Tumors of specialized gonadal stroma in human male patients.Androblastoma, sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor. Cancer 1959, 12, 944–957. [Google Scholar] [CrossRef]
- Marshall, F.F.; Kerr, W.S., Jr.; Kliman, B.; Scully, R.E. Sex cord stromal (gonadal stromal) tumors of the testis: A report of 5 cases. J. Urol. 1977, 117, 180–184. [Google Scholar] [CrossRef] [PubMed]
- Talerman, A. Pure granulosa cell tumour of the testis. Report of a case and review of the literature. Appl. Pathol. 1985, 3, 117–122. [Google Scholar] [PubMed]
- Gaylis, F.D.; August, C.; Yeldandi, A.; Nemcek, A.; Garnett, J. Granulosa Cell Tumor of the Adult Testis: Ultrastructural and Ultrasonographic Characteristics. J. Urol. 1989, 141, 126–127. [Google Scholar] [CrossRef]
- Düe, W.; Dieckmann, K.P.; Niedobitek, G.; Bornhöft, G.; Loy, V.; Stein, H. Testicular sex cord stromal tumour with granulosa cell differentiation: Detection of steroid hormone receptors as a possible basis for tumour development and therapeutic management. J. Clin. Pathol. 1990, 43, 732–737. [Google Scholar] [CrossRef] [Green Version]
- Nistal, M.; Lázaro, R.; García, J.; Paniagua, R. Testicular granulosa cell tumor of the adult type. Arch. Pathol. Lab. Med. 1992, 116, 284–287. [Google Scholar] [PubMed]
- Matoška, J.; Ondrus, D.; Talerman, A. Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival. Cancer 1992, 69, 1769–1772. [Google Scholar] [CrossRef] [PubMed]
- Sasano, H.; Nakashima, N.; Matsuzaki, O.; Kato, H.; Aizawa, S.; Sasano, N.; Nagura, H. Testicular sex cord-stromal lesions: Immunohistochemical analysis of cytokeratin, vimentin and steroidogenic enzymes. Virchows Arch. A Pathol. Anat. Histopathol. 1992, 421, 163–169. [Google Scholar] [CrossRef]
- Monobe, Y.; Manabe, T. Malignant Sex-cord Stromal Tumor of the Testis: Report of a Case with Special Reference to its Unusual Intracytoplasmic Substructures. Jpn. J. Clin. Oncol. 1992, 22, 414–420. [Google Scholar] [PubMed]
- A Renshaw, A.; Gordon, M.; Corless, C.L. Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Mod. Pathol. 1997, 10, 693–700. [Google Scholar] [PubMed]
- Morgan, D.R.; Brame, K.G. Granulosa cell tumour of the testis displaying immunoreactivity for inhibin. BJU Int. 2001, 83, 731–732. [Google Scholar] [CrossRef] [Green Version]
- Al-Bozom, I.A.; El-Faqih, S.R.; Hassan, S.H.; El-Tiraifi, A.E. Granulosa cell tumor of the adult type: A case report and review of the literature of a very rare testicular tumor. Arch. Pathol. Lab. Med. 2000, 124, 1525–1528. [Google Scholar] [CrossRef] [PubMed]
- Wang, B.Y.; Rabinowitz, D.S.; Granato, R.C.S.; Unger, P.D. Gonadal tumor with granulosa cell tumor features in an adult testis. Ann. Diagn. Pathol. 2002, 6, 56–60. [Google Scholar] [CrossRef]
- Guzzo, T.; Gerstein, M.; Mydlo, J.H. Granulosa Cell Tumor of the Contralateral Testis in a Man with a History of Cryptorchism. Urol. Int. 2004, 72, 85–87. [Google Scholar] [CrossRef] [PubMed]
- Suppiah, A.; Musa, M.M.; Morgan, D.R.; North, A.D. Adult granulosa cell tumour of the testis and bony metastasis: A report of the first case of granulosa cell tumour of the testicle metastasising to bone. Urol. Int. 2005, 75, 91–93. [Google Scholar] [CrossRef]
- Hisano, M.; Mascarenhas Souza, F.M.; Costa Malheiros, D.M.A.; Lima Pompeo, A.C.; Lucon, A.M. Granulosa cell tumor of the adult testis. Report of a case and review of the literature. Clinics 2006, 61, 77–78. [Google Scholar] [CrossRef] [Green Version]
- Arzola, J.; Hutton, R.L.; Baughman, S.M.; Mora, R.V. Adult-type testicular granulosa cell tumor: Case report and review of the literature. Urology 2006, 68, 1121.e13–1121.e16. [Google Scholar] [CrossRef]
- López, J.I. Adult-type granulosa cell tumor of the testis. Report of a case. Tumori 2007, 93, 223–224. [Google Scholar]
- Ditonno, P.; Lucarelli, G.; Battaglia, M.; Mancini, V.; Palazzo, S.; Trabucco, S.; Bettocchi, C.; Selvaggi, F.P. Testicular granulosa cell tumor of adult type: A new case and a review of the literature. Urol. Oncol. Semin. Orig. Investig. 2007, 25, 322–325. [Google Scholar] [CrossRef]
- Gupta, A.; Mathur, S.; Reddy, C.; Arora, B. Testicular granulosa cell tumor, adult type. Indian J. Pathol. Microbiol. 2008, 51, 405–406. [Google Scholar] [CrossRef]
- Hammerich, K.H.; Hille, S.; Ayala, G.E.; Wheeler, T.M.; Engers, R.; Ackermann, R.; Mueller-Mattheis, V. Malignant advanced granulosa cell tumor of the adult testis: Case report and review of the literature. Hum. Pathol. 2008, 39, 701–709. [Google Scholar] [CrossRef] [PubMed]
- Song, Z.; Vaughn, D.J.; Bing, Z. Adult type granulosa cell tumor in adult testis: Report of a case and review of the literature. Rare Tumors 2011, 3, 117–119. [Google Scholar] [CrossRef]
- Hanson, J.A.; Ambaye, A.B. Adult testicular granulosa cell tumor: A review of the literature for clinicopathologic predictors of malignancy. Arch. Pathol. Lab. Med. 2011, 135. [Google Scholar] [CrossRef] [PubMed]
- Lima, J.F.; Jin, L.; De Araujo, A.R.; Erikson-Johnson, M.R.; Oliveira, A.M.; Sebo, T.J.; Keeney, G.L.; Medeiros, F. Medeiros FOXL2 mutations in granulosa cell tumors occurring in males. Arch. Pathol. Lab. Med. 2012, 136, 825–828. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Köksal, I.T.; Usta, M.; Ciftcioglu, A.; Erdogru, T.; Kukul, E.; Baykara, M. Sex cord tumour of the adult testis. Int. Urol. Nephrol. 2003, 35, 365–367. [Google Scholar] [CrossRef]
- Mitra, A.; Palit, V.; Paes, R.; Ferro, M. Sonographic Features of an Adult Granulosa Cell Tumor of the Testis. Radiol. Case Rep. 2008, 3, 188. [Google Scholar] [CrossRef] [Green Version]
- Kucukodaci, Z.; Keles, M.; Yapanoglu, T.; Alp, B.F.; Aksoy, Y.; Ozbey, I. Adult type granulosa cell tumor of the testis: Case report and review of the literature. Eurasian J. Med. 2008, 40, 39–41. [Google Scholar]
- Harrison, M.R.; Huang, W.; Liu, G.; Gee, J. Response to antiangiogenesis therapy in a patient with advanced adult-type testicular granulosa cell tumor. Oncology 2009, 23, 792–795. [Google Scholar]
- Miliaras, D.; Anagnostou, E.; Moysides, I. Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature. Case Rep. Pathol. 2013, 2013, 932086. [Google Scholar] [CrossRef] [Green Version]
- Norman, R.W.; Sheridan-Jonah, A.; Merrimen, J.; Gupta, R. Adult granulosa cell tumor of the testicle. Can. J. Urol. 2013, 20, 6640–6642. [Google Scholar] [PubMed]
- Menon, S.; Desai, S.; Bakshi, G.; Joshi, A.; Rane, S.U. Granulosa cell tumor of testis: Clinicopathological correlation of a rare tumor. Indian J. Pathol. Microbiol. 2014, 57, 564–573. [Google Scholar] [CrossRef] [PubMed]
- Tanner, S.B.; Morilla, D.B.; Schaber, J.D. A Case of Adult Granulosa Cell Tumor of the Testis. Am. J. Case Rep. 2014, 15, 471–475. [Google Scholar]
- Tsitouridis, I.; Maskalidis, C.; Sdrolia, A.; Pervana, S.; Pazarli, E.; Kariki, E.P. Adult type granulosa cell tumor of the testis: Radiological evaluation and review of the literature. Turk. J. Urol. 2014, 40, 115–119. [Google Scholar] [CrossRef]
- Giulianelli, R.; Mirabile, G.; Vincenti, G.; Pellegrino, F.; Soda, G. A very rare case of adult-type granulosa cell tumor. Arch. Ital. Urol. Androl. 2015, 87, 98. [Google Scholar] [CrossRef] [Green Version]
- Vallonthaiel, A.G.; Kakkar, A.; Singh, A.; Dogra, P.N.; Ray, R. Adult granulosa cell tumor of the testis masquerading as hydrocele. Int. Braz. J. Urol. 2015, 41, 1226–1231. [Google Scholar] [CrossRef] [Green Version]
- Gómez-Valcárcel, J.; de Dios Barranco-García, J.; García-Muñoz, I. Tumor de células de la granulosa de tipo adulto. Un caso raro de tumor testicular. Present. Discus. Tres Casos Clín. 2016, 49, 62–65. [Google Scholar]
- Mohapatra, A.; Potretzke, A.M.; Knight, B.A.; Han, M.; Figenshau, R.S. Metastatic Granulosa Cell Tumor of the Testis: Clinical Presentation and Management. Case Rep. Urol. 2016, 2016, 9016728. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Al-Alao, O.; Gul, T.; Al-Ani, A.; Bozom, I.A.; Al-Jalham, K. Adult-type granulosa cell tumour of the testis: Report of a case and review of the literature. Arab. J. Urol. 2016, 14, 44–49. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bani, M.A.; Zehani, A.; Chelly, I.; Fethi, A.; Haouet, S.; Kchir, N. Adult granulosa cell tumor of the testis: A case report. Tunis. Méd. 2016, 94, 897. [Google Scholar]
- Mezentsev, V.; Ali, H.; McKenzie, J.; Virdi, J. Adult type granulosa cell tumour of the testis: A case report. Cancer Urol. 2017, 13, 134–138. [Google Scholar] [CrossRef] [Green Version]
- Meilán, E.; Esquinas, C.; Romero, I.; Duarte, J.; García-Tello, A. Adult type granulosa cell testicular tumor. Case Rep. Bibliogr. Rev. Arch. Esp. Urol. 2017, 70, 617–620. [Google Scholar]
- Nunes-Carneiro, D.; Marques-Pinto, A.; Cavadas, V.; Fraga, A. Adult testicular granulosa cell tumour: An extremely rare entity. BMJ Case Rep. 2018, 2018, bcr-2018. [Google Scholar] [CrossRef]
- Kabore, M.; Ido, F.; Yameogo, C.A.; Ouedraogo, A.A.; Kirakoya, B.; Kabore, F.A. Adult Granulosa Cell Tumor of the Testis: A case report and review of the literature. Urol. Case Rep. 2021, 38, 101718. [Google Scholar] [CrossRef] [PubMed]
- Featherstone, J.; Fernando, H.; Theaker, J.; Simmonds, P.; Hayes, M.; Mead, G. Sex Cord Stromal Testicular Tumors: A Clinical Series—Uniformly Stage I Disease. J. Urol. 2009, 181, 2090–2096, discussion 2096. [Google Scholar] [CrossRef]
- Garrett, J.E.; Cartwright, P.C.; Snow, B.W.; Coffin, C.M. Cystic testicular lesions in the pediatric population. J. Urol. 2000, 163, 928. [Google Scholar] [CrossRef]
- Acar, C.; Gurocak, S.; Sozen, S. Current Treatment of Testicular Sex Cord-stromal Tumors: Critical Review. Urology 2009, 73, 1165–1171. [Google Scholar] [CrossRef] [PubMed]
- Jimenez-Quintero, L.P.; Ro, J.Y.; Zavala-Pompa, A.; Amin, M.B.; Tetu, B.; Ordoñez, N.G.; Ayala, A.G. Granulosa cell tumor of the adult testis: A clinicopathologic study of seven cases and a review of the literature. Hum. Pathol. 1993, 24, 1120–1126. [Google Scholar] [CrossRef] [PubMed]
- Cornejo, K.M.; Young, R.H. Adult granulosa cell tumors of the testis: A report of 32 cases. Am. J. Surg. Pathol. 2014, 38, 1242–1250. [Google Scholar] [CrossRef]
- Zeuschner, P.; Veith, C.; Linxweiler, J.; Stöckle, M.; Heinzelbecker, J. Two Years of Gynecomastia Caused by Leydig Cell Tumor. Case Rep. Urol. 2018, 2018, 7202560. [Google Scholar] [CrossRef]
- Silberstein, J.L.; Bazzi, W.M.; Vertosick, E.; Carver, B.S.; Bosl, G.J.; Feldman, D.R.; Bajorin, D.F.; Motzer, R.J.; Al-Ahmadie, H.; Reuter, V.E.; et al. Clinical Outcomes of Local and Metastatic Testicular Sex Cord-Stromal Tumors. J. Urol. 2014, 192, 415–419. [Google Scholar] [CrossRef] [PubMed]
- Calaway, A.C.; Tachibana, I.; Masterson, T.A.; Foster, R.S.; Einhorn, L.H.; Cary, C. Oncologic Outcomes Following Surgical Management of Clinical Stage II Sex Cord Stromal Tumors. Urology 2019, 127, 74–79. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Azizi, M.; Aydin, A.M.; Cheriyan, S.K.; Peyton, C.C.; Montanarella, M.; Gilbert, S.M.; Sexton, W.J. Therapeutic strategies for uncommon testis cancer histologies: Teratoma with malignant transformation and malignant testicular sex cord stromal tumors. Transl. Androl. Urol. 2020, 9 (Suppl. S1), S91–S103. [Google Scholar] [CrossRef] [PubMed]
Author | Year | Age (Years) | Tumor Size (cm) | Side of Tumor | Metastatic | Presenting Symptom | Endocrine Symptoms | F/U |
---|---|---|---|---|---|---|---|---|
Laskovski | 1952 | 35 | 9 | R | gynecomastia | 8.5 | ||
Cohen | 1953 | 21 | <1 | L | incidental | gynecomastia | Ns | |
Massachusetts case | 1955 | 53 | 10 | R | gynecomastia | Ns | ||
Melicow | 1955 | 52 | 13 | R | Ns | |||
Mostofi | 1959 | 41 | 10.1 | L | metastatic | mass, no pain | gynecomastia | DOD 5m |
Marshall | 1977 | 53 | 10 | NS | mass, no pain | gynecomastia | 17y | |
Talerman | 1985 | 44 | 3.5 | R | mass, no pain | 3y | ||
Gaylis | 1989 | 41 | 1.8 | R | painful mass | gynecomastia | Ns | |
Düe | 1990 | 83 | 18 | L | DOC 1m | |||
Nistal | 1992 | 61 | 5 | R | Ns | |||
Matoska | 1992 | 26 | 10 | L | malignant | 14y NED | ||
Sasano | 1992 | Ns | Ns | NS | Ns | |||
Monobe | 1992 | 42 | Ns | L | malignant | AWD | ||
Jiminez-Quintero | 1993 | 57 | 2.5 | R | 3y DOC | |||
Jiminez-Quintero | 1993 | 55 | 1.3 | L | 3y NED | |||
Jiminez-Quintero | 1993 | 60 | 7 | L | malignant | |||
Jiminez-Quintero | 1993 | 39 | 4 | L | NED 1m | |||
Jiminez-Quintero | 1993 | 29 | 7.5 | R | malignant | Ns | ||
Jiminez-Quintero | 1993 | 76 | 0.7 | L | Ns | |||
Renshaw | 1997 | Ns | Ns | NS | Ns | |||
Renshaw | 1997 | Ns | Ns | NS | ||||
Renshaw | 1997 | Ns | Ns | NS | ||||
Morgan | 1999 | 49 | 2.6 | L | ||||
Al-Bozom | 2000 | 48 | 5 | R | 2y NED | |||
Wang | 2002 | 54 | Ns | L | hydrocele, asymptomatic | 7m NED | ||
Guzzo | 2004 | 33 | 1 | L | Ns | |||
Suppiah | 2005 | 51 | Ns | L | malignant | Ns | ||
Hisano | 2006 | 59 | 15 | L | 6y AWD | |||
Arzola | 2006 | 32 | 2.1 | L | painless mass | 4y NED | ||
Lopez | 2007 | 77 | 4 | L | ||||
Ditonno | 2007 | 45 | 6.5 | R | painless mass | Ns | ||
Gupta | 2008 | 12 | 8 | L | 2y Ned | |||
Hammerich | 2008 | 55 | Ns | NS | malignant | 1y NED | ||
Song | 2011 | 28 | 2.6 | L | 3y NED | |||
Hanson | 2011 | 21 | 1 | L | Ns | |||
Lima | 2012 | 77 | 2.5 | R | 2y NED | |||
Lima | 2012 | 22 | 1 | L | Ns | |||
Lima | 2012 | 40 | 2.1 | L | Ns | |||
Schubert | 2014 | 78 | 1.3 | L | painless mass | |||
Cornejo | 2014 | 49 | 3 | R | 23m NED | |||
Cornejo | 2014 | 22 | 3.3 | L | 137m, DOOD | |||
Cornejo | 2014 | 50 | 0.9 | L | 48m | |||
Cornejo | 2014 | Nd | 3 | L | 59m | |||
Cornejo | 2014 | 27 | 1.8 | R | lost | |||
Cornejo | 2014 | 87 | Ns | NS | 60m | |||
Cornejo | 2014 | 47 | 4.5 | R | 169m | |||
Cornejo | 2014 | 51 | 2.1 | R | lost | |||
Cornejo | 2014 | 47 | 0.5 | L | 58m | |||
Cornejo | 2014 | 55 | 2.1 | L | lost | |||
Cornejo | 2014 | 25 | 2 | R | 80m | |||
Cornejo | 2014 | 45 | 1.4 | R | lost | |||
Cornejo | 2014 | 74 | 3.5 | L | lost | |||
Cornejo | 2014 | 27 | 1.4 | R | 104m | |||
Cornejo | 2014 | 32 | 4.2 | R | 36m | |||
Cornejo | 2014 | 18 | 3.2 | L | lost | |||
Cornejo | 2014 | 60 | 6 | R | lost | |||
Cornejo | 2014 | 23 | 1.4 | R | lost | |||
Cornejo | 2014 | 20 | 4.5 | L | 65m | |||
Cornejo | 2014 | 52 | 4.3 | R | malignant | 1m | ||
Cornejo | 2014 | 14 | 0.8 | R | 24m AWD | |||
Cornejo | 2014 | 21 | 3 | R | lost | |||
Cornejo | 2014 | 17 | 1.5 | R | 37m | |||
Cornejo | 2014 | 64 | 2.4 | R | lost | |||
Cornejo | 2014 | 14 | 3.5 | R | 28m | |||
Cornejo | 2014 | 28 | 2.6 | L | 35m | |||
Cornejo | 2014 | 51 | 3 | L | lost | |||
Cornejo | 2014 | 63 | 1 | L | lost | |||
Cornejo | 2014 | 25 | 5.5 | R | 25m | |||
Cornejo | 2014 | 44 | 1.2 | L | 1m | |||
Cornejo | 2014 | 50 | 4.7 | R | 1m | |||
Köksal | 2003 | 40 | 3.5 | R | 8-month mass | 20m | ||
Mitra | 2008 | 25 | 0.5 | L | scrotal pain 2 weeks | lost | ||
Kucukodaci | 2008 | 21 | 1.5 | L | incidental | 1 year | ||
Harrison | 2009 | 65 | 5 | L | malignant | DOD | ||
Miliaris | 2013 | 37 | 4.2 | L | painless mass | 2 years | ||
Norman | 2013 | 68 | Ns | R | 18m | |||
Rane | 2014 | 34 | 5 | R | 6m | |||
Rane | 2014 | 46 | 65 | L | 2.5 years | |||
Rane | 2014 | 46 | 11 | R | malignant | 3m | ||
Tanner | 2014 | 22 | 0.6 | L | Ns | |||
Tsitouridis | 2015 | 29 | 2.5 | R | 1 year | |||
Giulianelli | 2015 | 80 | 6 | R | mass, no pain | gynecomastia | 1 year | |
Vallonthaiel | 2015 | 43 | 6 | L | painless mass | 1 year | ||
Gomez-Valcarcel | 2016 | 23 | Ns | NS | Ns | |||
Mohapatra | 2016 | 57 | 4.7 | L | malignant | incidental | gynecomastia | 32m NED |
Al-Alao | 2016 | 48 | 1.2 | L | Ns | |||
Bani | 2017 | 20 | 2 | R | 4m NED | |||
Elbachiri | 2017 | 40 | 5.5 | L | malignant | painless growing mass | 2 years NED | |
Mezentsev | 2017 | 74 | 5 | R | painless mass | Ns | ||
Meilan | 2017 | 59 | 3.3 | NS | Ns | |||
Nunes-Carneiro | 2017 | 31 | 4.5 | NS | 10 years | |||
Dieckmann | 2019 | 22 | 0.8 | L | scrotal discomfort | Ns | ||
Kabore | 2021 | 64 | 1 | L | painless testicular swelling | Ns | ||
Present report | 2022 | 30 | 3.8 | L | painless testicular swelling | 10m |
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Zervopoulos, G.; Mitsimponas, N.; Venetsanos, F.; Papathanasis, A. Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature. Uro 2023, 3, 177-186. https://doi.org/10.3390/uro3030019
Zervopoulos G, Mitsimponas N, Venetsanos F, Papathanasis A. Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature. Uro. 2023; 3(3):177-186. https://doi.org/10.3390/uro3030019
Chicago/Turabian StyleZervopoulos, Georgios, Nikolaos Mitsimponas, Filippos Venetsanos, and Athanasios Papathanasis. 2023. "Adult-Type Granulosa Cell Tumor of the Testis: A Report of a Case and a Discussion of the Literature" Uro 3, no. 3: 177-186. https://doi.org/10.3390/uro3030019