The Role of Immune Cells in Liver Regeneration

Round 1

Reviewer 1 Report

Dear Yankai Wen, 

i appreciate the opportunity to review the manuscript titled "The Role of the Immune Cells in liver regeneration" ad commend this important topic. However, after careful consideration, i believe that the paper would benefit from major revisions before it can be reconsidered for publication.

One notable concern is that the manuscript appears to be overly saturated with information at times, sometimes lacking clear connection between ideas. It would greatly enhance the readability and cohesiveness of the paper if you could streamline the content and ensure a smooth flow of information. 

Futhermore, the section on macrophages seems disproportionately lenght and repetitive, leading to potential reader fatigue. I raccomend considering and refining this section, highlighting the key findings and eliminating redundant information.

Another issue is the frequent introduction of new markers and abbreviations without proper explanation. This hampers the understanding of the paper, especially for readers who may not be familiar with all the specific markers referenced. I encourage to provide clear explanations or definitions of these markers upon their first mention.

Addressing these concerns through major revisions will greatly improve the clarity and coherence of the manuscript, making it more accessible and impactful for the scientific community.   

Author Response

i appreciate the opportunity to review the manuscript titled "The Role of the Immune Cells in liver regeneration" ad commend this important topic. However, after careful consideration, i believe that the paper would benefit from major revisions before it can be reconsidered for publication.

 

One notable concern is that the manuscript appears to be overly saturated with information at times, sometimes lacking clear connection between ideas. It would greatly enhance the readability and cohesiveness of the paper if you could streamline the content and ensure a smooth flow of information. 

 

Reply: Thank you for the reviewer's comment. To enhance the readability and cohesiveness of the manuscript, we reorganized the contents and included some connections between views.

 

 

Futhermore, the section on macrophages seems disproportionately lenght and repetitive, leading to potential reader fatigue. I raccomend considering and refining this section, highlighting the key findings and eliminating redundant information.

 

Reply: As we know, among all the immune cells, macrophages are the most widely and intensively investigated in liver regeneration. Therefore, we spent around 40% of the manuscript to summarize and discuss the role of macrophages in liver regeneration. However, we are sorry to make the reviewer feel fatigued to the manuscript. Per the reviewer's suggestion, we deleted the repetitive and redundant content and refined this section.

 

 

Another issue is the frequent introduction of new markers and abbreviations without proper explanation. This hampers the understanding of the paper, especially for readers who may not be familiar with all the specific markers referenced. I encourage to provide clear explanations or definitions of these markers upon their first mention.

 

Reply: We appreciate this comment. As the reviewer suggested, we provided the full definitions of all the genes and markers in this manuscript. And we also listed all the abbreviations at the end of the current manuscript.

 

 

Addressing these concerns through major revisions will greatly improve the clarity and coherence of the manuscript, making it more accessible and impactful for the scientific community.

Reviewer 2 Report

An interesting review of the literature on the effect of immune system cells on liver regeneration is presented. In addition to cells, which, in accordance with classical concepts, are immune, the author provides data on platelets.

Among the questions I would like to clarify the role of FOXP3+ lymphocytes in liver regeneration.

Author Response

An interesting review of the literature on the effect of immune system cells on liver regeneration is presented. In addition to cells, which, in accordance with classical concepts, are immune, the author provides data on platelets.

Among the questions I would like to clarify the role of FOXP3+ lymphocytes in liver regeneration.

 

Reply: Thank you for your suggestion. We completed the Section of "B and T cells" by adding the description and discussion of Foxp3+ regulatory T cells.

Reviewer 3 Report

Thank you very much for giving the chance to review this paper entitled " The Role of Immune Cells in Liver Regeneration” The authors focus on the Role of Immune Cells in Liver Regeneration.

This was a very well-done review study and the data reported is succinct and well-presented. But still had some scientific issue need further recognized.

 

 

1.      The structure of this article is too similar to another article “Immune cells in liver regeneration. Oncotarget, 2017, 8.2: 3628.” Please consider modified the subtitle and structure of this paper.

2.      This article figure 1 was too similar to above article “ figure 3”. Please modified this.

Comments for author File: Comments.pdf

I think this paper english was well wright. 

Author Response

Thank you very much for giving the chance to review this paper entitled " The Role of Immune Cells in Liver Regeneration” The authors focus on the Role of Immune Cells in Liver Regeneration.

This was a very well-done review study and the data reported is succinct and well-presented. But still had some scientific issue need further recognized. 

1. The structure of this article is too similar to another article “Immune cells in liver regeneration. Oncotarget, 2017, 8.2: 3628.” Please consider modified the subtitle and structure of this paper.

 

Reply: Thank you for your suggestion. We must admit that we have a very similar structure to the paper mentioned because we both talked about the immune cells in liver regeneration. However, the Oncotarget paper only mentioned the role of immune cells in partial hepatectomy-induced liver regeneration. And we are talking about the immune cells in different types of liver regeneration including progenitor cell-mediated liver regeneration. We also highlighted the roles of innate lymphoid cells and platelets in liver regeneration, which has not been discussed in the Oncotarget manuscript. Per the reviewer's comment, we also added a Section of "Compensatory regeneration and progenitor cell-mediated regeneration", which helps readers to understand the types of liver regeneration in this manuscript.

 

 

2. This article figure 1 was too similar to above article “ figure 3”. Please modified this.

 

Reply: Thank you for the comment. We revised Figure 1 to avoid the similarity.

Round 2

Reviewer 1 Report

Kudos to the author for his dedicated efforts in incorporating the reviewer´s feedback and making substantial improvements to the paper. The revisions have enhanced the clarity and overall presentation of the research.

Author Response

Kudos to the author for his dedicated efforts in incorporating the reviewer´s feedback and making substantial improvements to the paper. The revisions have enhanced the clarity and overall presentation of the research.

Reply: Thank you for the reviewer's comments to improve our manuscript.

Reviewer 3 Report

This was a very well-done study and the data reported is succinct and well-presented. Author had complete response the previous reviewer’s suggestion and revised well.

 

But before accepted this article, authors need improve the English writing with native academic professor.

After that, may consider accepted this article.

This was a very well-done study and the data reported is succinct and well-presented. Author had complete response the previous reviewer’s suggestion and revised well. 

Authors need improve the English writing with native academic professor.

 

Author Response

This was a very well-done study and the data reported is succinct and well-presented. Author had complete response the previous reviewer’s suggestion and revised well. 

But before accepted this article, authors need improve the English writing with native academic professor.

After that, may consider accepted this article.

 

Reply: We appreciate the reviewer's comment. We have this manuscript revised by the Professional English Editing Service from MDPI.