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Article

Postprandial Triglycerides, Flow-Mediated Dilation, and the Inflammatory Cytokine Milieu in Metabolically Healthy Obesity: A Cross-Sectional Pilot Study

1
Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA
2
211 Human Sciences, Oklahoma State University, Stillwater, OK 74078, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Bruno Guigas
Obesities 2021, 1(1), 58-71; https://doi.org/10.3390/Obesities1010006
Received: 22 May 2021 / Revised: 6 June 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
The cardiovascular disease (CVD) risk of metabolically healthy obesity (MHO) remains controversial. We sought to further characterize the CVD risk profile in MHO by evaluating postprandial triglycerides, vascular function, and systemic inflammatory markers. Control individuals that were normal-weight and metabolically healthy (Con), MHO, and metabolic syndrome (MetS) were recruited (n = 10–11/group). Each participant underwent an abbreviated fat tolerance test, fasting and postprandial flow-mediated dilation (FMD), and had a panel of inflammatory cytokines measured. MHO displayed postprandial triglycerides similar to those in Con and both MHO and Con had lower values than those for MetS (p < 0.01). Fasting FMD was lower in MHO and MetS compared to that of Con (p < 0.01), but during the postprandial period the vasodilatory response of MHO was similar to that while fasting (p = 0.39), while FMD in Con and MetS decreased after the high-fat meal (p values < 0.01). MHO displayed a number of inflammatory cytokines greater than those of Con and MetS (all p values < 0.05), while MetS and MHO had higher TNF-α than did Con (p < 0.05). In conclusion, MHO was associated with lower fasting FMD and a greater inflammatory burden but did not suffer the same negative postprandial effects as did MetS. View Full-Text
Keywords: metabolically healthy obesity; postprandial triglycerides; flow-mediated dilation; inflammation; metabolic syndrome; adiposity; cardiovascular disease metabolically healthy obesity; postprandial triglycerides; flow-mediated dilation; inflammation; metabolic syndrome; adiposity; cardiovascular disease
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MDPI and ACS Style

Keirns, B.H.; Hart, S.M.; Sciarrillo, C.M.; Poindexter, K.L.; Clarke, S.L.; Emerson, S.R. Postprandial Triglycerides, Flow-Mediated Dilation, and the Inflammatory Cytokine Milieu in Metabolically Healthy Obesity: A Cross-Sectional Pilot Study. Obesities 2021, 1, 58-71. https://doi.org/10.3390/Obesities1010006

AMA Style

Keirns BH, Hart SM, Sciarrillo CM, Poindexter KL, Clarke SL, Emerson SR. Postprandial Triglycerides, Flow-Mediated Dilation, and the Inflammatory Cytokine Milieu in Metabolically Healthy Obesity: A Cross-Sectional Pilot Study. Obesities. 2021; 1(1):58-71. https://doi.org/10.3390/Obesities1010006

Chicago/Turabian Style

Keirns, Bryant H., Samantha M. Hart, Christina M. Sciarrillo, Kara L. Poindexter, Stephen L. Clarke, and Sam R. Emerson 2021. "Postprandial Triglycerides, Flow-Mediated Dilation, and the Inflammatory Cytokine Milieu in Metabolically Healthy Obesity: A Cross-Sectional Pilot Study" Obesities 1, no. 1: 58-71. https://doi.org/10.3390/Obesities1010006

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