Organizing Pneumonia and Microvascular Fibrosis as Late Sequelae after a COVID-19 Infection. A Case Report
Abstract
:1. Introduction
2. Case Presentation
2.1. Operative Findings
2.2. Pathology Findings
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Zhou, P.; Yang, X.L.; Wang, X.G.; Hu, B.; Zhang, L.; Zhang, W.; Shi, Z.L. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020, 579, 270–273. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- COVID-19 Map. Johns Hopkins Coronavirus Resource Center. Available online: https://coronavirus.jhu.edu/map.html (accessed on 21 April 2021).
- Technical Guidance. Available online: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance (accessed on 21 April 2021).
- Wang, X.; Tu, Y.; Huang, B.; Li, Y.; Li, Y.; Zhang, S.; Luo, H. Pulmonary vascular endothelial injury and acute pulmonary hypertension caused by COVID-19: The fundamental cause of refractory hypoxemia? Cardiovasc. Diagn. Ther. 2020, 10, 892–897. [Google Scholar] [CrossRef] [PubMed]
- Menter, T.; Haslbauer, J.D.; Nienhold, R.; Savic, S.; Hopfer, H.; Deigendesch, N.; Tzankov, A. Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology 2020, 77, 198–209. [Google Scholar] [CrossRef]
- Wichmann, D.; Sperhake, J.P.; Lütgehetmann, M.; Steurer, S.; Edler, C.; Heinemann, A.; Heinrich, F.; Mushumba, H.; Kniep, I.; Schröder, A.S.; et al. Autopsy Findings and Venous Thromboembolism in Patients with COVID-19. Ann. Intern. Med. 2020, 173, 268–277. [Google Scholar] [CrossRef] [PubMed]
- Flikweert, A.W.; Grootenboers, M.J.; Yick, D.C.; du Mée, A.W.; van der Meer, N.J.; Rettig, T.C.; Kant, M.K. Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series. J. Crit. Care 2020, 59, 149–155. [Google Scholar] [CrossRef] [PubMed]
- Aiolfi, A.; Bruni, B.; Biraghi, T.; Montisci, A.; Miceli, A.; Baronio, B.; Khor, D.; Cirri, S.; Donatelli, F.; Clemente, C.; et al. Late histological findings in symptomatic COVID-19 patients: A case report. Medicine 2020, 99, e21046. [Google Scholar] [CrossRef] [PubMed]
- Xu, Z.; Shi, L.; Wang, Y.; Zhang, J.; Huang, L.; Zhang, C.; Liu, S.; Zhao, P.; Liu, H.; Zhu, L.; et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir. Med. 2020, 8, 420–422. [Google Scholar] [CrossRef]
- Li, W.; Moore, M.J.; Vasilieva, N.; Sui, J.; Wong, S.K.; Berne, M.A.; Somasundaran, M.; Sullivan, J.L.; Luzuriaga, K.; Greenough, T.C.; et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003, 426, 450–454. [Google Scholar] [CrossRef] [Green Version]
- Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Kruger, N.; Herrler, T.; Erichsen, S.; Schiergens, T.S.; Herrler, G.; Wu, N.; Nitsche, A.; et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 2020, 181, 271–280.e8. [Google Scholar] [CrossRef]
- Sungnak, W.; Huang, N.; Becavin, C.; Berg, M.; Queen, R.; Litvinukova, M.; Talavera-Lopez, C.; Maatz, H.; Reichart, D.; Sampaziotis, F.; et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat. Med. 2020, 26, 681–687. [Google Scholar] [CrossRef] [Green Version]
- Hamming, I.; Timens, W.; Bulthuis ML, C.; Lely, A.T.; Navis, G.V.; van Goor, H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J. Pathol. 2004, 203, 631–637. [Google Scholar] [CrossRef]
- Sutton, D.; Fuchs, K.; D’Alton, M.; Goffman, D. Universal Screening for SARS-CoV-2 in Women Admitted for Delivery. N. Engl. J. Med. 2020, 382, 2163–2164. [Google Scholar] [CrossRef]
- Oran, D.P.; Topol, E.J. Prevalence of Asymptomatic SARS-CoV-2 Infection: A Narrative Review. Ann. Intern. Med. 2020, 173, 362–367. [Google Scholar] [CrossRef] [PubMed]
- Wu, Z.; McGoogan, J.M. Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention. JAMA 2020, 323, 1239–1242. [Google Scholar] [CrossRef]
- Endeman, H.; van der Zee, P.; van Genderen, M.E.; van den Akker, J.P.C.; Gommers, D. Progressive respiratory failure in COVID-19: A hypothesis. Lancet Infect. Dis. 2020, 20, 1365. [Google Scholar] [CrossRef]
- Klok, F.A.; Kruip, M.J.H.A.; van der Meer, N.J.M.; Arbous, M.S.; Gommers, D.A.M.P.J.; Kant, K.M.; Kaptein, F.H.J.; van Paassen, J.; Stals, M.A.M.; Huisman, M.V. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb. Res. 2020, 191, 145–147. [Google Scholar] [CrossRef]
- Bilaloglu, S.; Aphinyanaphongs, Y.; Jones, S.; Iturrate, E.; Hochman, J.; Berger, J.S. Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System. JAMA 2020, 324, 799–801. [Google Scholar] [CrossRef] [PubMed]
- Libby, P.; Lüscher, T. COVID-19 is, in the end, an endothelial disease. Eur. Heart J. 2020, 41, 3038–3044. [Google Scholar] [CrossRef] [PubMed]
- Schwensen, H.F.; Borreschmidt, L.K.; Storgaard, M.; Redsted, S.; Christensen, S.; Madsen, L.B. Fatal pulmonary fibrosis: A post-COVID-19 autopsy case. J. Clin. Pathol. 2020, 74. [Google Scholar] [CrossRef]
- Vadász, I.; Husain-Syed, F.; Dorfmüller, P.; Roller, F.C.; Tello, K.; Hecker, M.; E Morty, R.; Gattenlöhner, S.; Walmrath, H.-D.; Grimminger, F.; et al. Severe organising pneumonia following COVID-19. Thorax 2021, 76, 201–204. [Google Scholar] [CrossRef]
- Simões, J.P.; Ferreira, A.R.A.; Almeida, P.M.; Trigueiros, F.; Braz, A.; Inácio, J.R.; Medeiros, F.C.; Braz, S.; de Lacerda, A.P. Organizing pneumonia and COVID-19: A report of two cases. Respir. Med. Case Rep. 2021, 32, 101359. [Google Scholar] [CrossRef] [PubMed]
- Mishra, G.P.; Mulani, J. Corticosteroids for COVID-19: The search for an optimum duration of therapy. Lancet Respir. Med. 2021, 9, e8. [Google Scholar] [CrossRef]
- Myall, K.J.; Mukherjee, B.; Castanheira, A.M.; Lam, J.L.; Benedetti, G.; Mak, S.M.; Preston, R.; Thillai, M.; Dewar, A.; Molyneaux, P.L.; et al. Persistent Post–COVID-19 Interstitial Lung Disease. An Observational Study of Corticosteroid Treatment. Ann. Am. Thorac. Soc. 2021, 18, 799–806. [Google Scholar] [CrossRef] [PubMed]
- Chen, J.-Y.; Qiao, K.; Liu, F.; Wu, B.; Xu, X.; Jiao, G.-Q.; Lu, R.-G.; Li, H.-X.; Zhao, J.; Huang, J.-A.; et al. Lung transplantation as therapeutic option in acute respiratory distress syndrome for coronavirus disease 2019-related pulmonary fibrosis. Chin. Med J. 2020, 133, 1390–1396. [Google Scholar] [CrossRef]
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Dikken, J.L.; Maat, A.P.W.M.; Wolf, J.L.; Endeman, H.; Hoek, R.A.S.; Bogers, A.J.J.C.; Mahtab, E.A.F. Organizing Pneumonia and Microvascular Fibrosis as Late Sequelae after a COVID-19 Infection. A Case Report. Surgeries 2021, 2, 190-198. https://doi.org/10.3390/surgeries2020020
Dikken JL, Maat APWM, Wolf JL, Endeman H, Hoek RAS, Bogers AJJC, Mahtab EAF. Organizing Pneumonia and Microvascular Fibrosis as Late Sequelae after a COVID-19 Infection. A Case Report. Surgeries. 2021; 2(2):190-198. https://doi.org/10.3390/surgeries2020020
Chicago/Turabian StyleDikken, Johan L., Alexander P. W. M. Maat, Janina L. Wolf, Henrik Endeman, Rogier A. S. Hoek, Ad J. J. C. Bogers, and Edris A. F. Mahtab. 2021. "Organizing Pneumonia and Microvascular Fibrosis as Late Sequelae after a COVID-19 Infection. A Case Report" Surgeries 2, no. 2: 190-198. https://doi.org/10.3390/surgeries2020020