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Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy

Unitè 1171 “Degenerative and Vascular Cognitive Disorders”, Université de Lille 2, 2275 Lille, France
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NeuroSci 2020, 1(2), 115-120; https://doi.org/10.3390/neurosci1020011
Received: 30 October 2020 / Revised: 16 December 2020 / Accepted: 18 December 2020 / Published: 21 December 2020
(This article belongs to the Special Issue Feature Papers in Neurosci)
Introduction and Purpose: Cerebral amyloid angiopathy (CAA) can be observed in patients with progressive supranuclear palsy (PSP), though to a lesser degree than in Alzheimer’s disease. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) evaluates whether CAA has an influence on the degree of hippocampal atrophy (HA) and on the incidence of associated micro-infarcts (HMIs) and cortical micro-bleeds (HMBs). Material and Methods: Eight brains with PSP-CAA were compared to 20 PSP brains without CAA. In addition to the neuropathological examination, the hippocampus was evaluated on the most representative coronal section with T2 and T2*-weighted MRI sequences. The average degree of HA was determined in both groups. The incidence of HMIs and HMBs was also compared as well as the frequency of cortical micro-infarcts (CoMIs) and cortical micro-bleeds (CoMBs) in the hemispheric neocortex. Results: The neuropathological examination showed a higher incidence of lacunar infarcts in the PSP-CAA brains compared to the PSP ones. With magnetic resonance imaging (MRI), the severity of HA and the incidence of HMIs and HMBs was similar between both groups. Additionally, the frequency of CoMIs and CoMBs in the neocortex was comparable. Conclusions: The association of CAA in PSP brains has no influence on the degree of HA and on the incidence of the small cerebrovascular lesions in the hippocampus as well as in the neocortex. View Full-Text
Keywords: neuropathology; magnetic resonance imaging; progressive supranuclear palsy; cerebral amyloid angiopathy; hippocampus; cerebral neocortex neuropathology; magnetic resonance imaging; progressive supranuclear palsy; cerebral amyloid angiopathy; hippocampus; cerebral neocortex
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MDPI and ACS Style

De Reuck, J.; Auger, F.; Durieux, N.; Maurage, C.-A.; Deramecourt, V.; Cordonnier, C.; Pasquier, F.; Leys, D.; Bordet, R. Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy. NeuroSci 2020, 1, 115-120. https://doi.org/10.3390/neurosci1020011

AMA Style

De Reuck J, Auger F, Durieux N, Maurage C-A, Deramecourt V, Cordonnier C, Pasquier F, Leys D, Bordet R. Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy. NeuroSci. 2020; 1(2):115-120. https://doi.org/10.3390/neurosci1020011

Chicago/Turabian Style

De Reuck, Jacques; Auger, Florent; Durieux, Nicolas; Maurage, Claude-Alain; Deramecourt, Vincent; Cordonnier, Charlotte; Pasquier, Florence; Leys, Didier; Bordet, Regis. 2020. "Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy" NeuroSci 1, no. 2: 115-120. https://doi.org/10.3390/neurosci1020011

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