Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Assay
2.3. Instantaneous Secretory Rates (ISR) Computation for the GnRH Stimulation Test
2.4. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Patient sn = 17 | LH mUI/mL | FSH mUI/mL | PRL ng/mL | E2 pg/mL | P ng/mL | Cortisol µg/100 mL | T ng/mL | A ng/mL | Insulin µUI/mL |
---|---|---|---|---|---|---|---|---|---|
Baseline | 1.85 ± 0.32 | 3.44 ± 0.43 | 11.99 ± 1.86 | 33.46 ± 8.05 | 0.46 ± 0.06 | 15.9 ± 3.5 | 19 ± 2.1 | 190.8 ± 10.4 | 2.86 ± 0.45 |
After treatment | 3.52 ± 0.7 * | 5.02 ± 0.54 * | 10.8 ± 1.9 | 28.67 ± 4.9 | 0.85 ± 0.34 | 16.1 ± 2.9 | 28.3 ± 13 | 214 ± 29.76 | 3.78 ± 0.7 |
LH Pulse After GnRH Test | Amplitude (Plasma Concentration) mIU/mL | Amplitude (ISR) mIU/mL |
---|---|---|
Baseline | 15.2 ± 1.6 | 9.5 ± 0.9 $ |
After 12 weeks of treatment | 24.6 ± 5.7 * | 13.5 ± 2.4 * $ |
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Genazzani, A.D.; Despini, G.; Prati, A.; Manzo, A.; Petrillo, T.; Tomatis, V.; Giannini, A.; Simoncini, T. Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study. Endocrines 2020, 1, 35-45. https://doi.org/10.3390/endocrines1010004
Genazzani AD, Despini G, Prati A, Manzo A, Petrillo T, Tomatis V, Giannini A, Simoncini T. Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study. Endocrines. 2020; 1(1):35-45. https://doi.org/10.3390/endocrines1010004
Chicago/Turabian StyleGenazzani, Alessandro D., Giulia Despini, Alessia Prati, Alba Manzo, Tabatha Petrillo, Veronica Tomatis, Andrea Giannini, and Tommaso Simoncini. 2020. "Administration of Very Low Doses of Estradiol Modulates the LH Response to a GnRH Bolus and the LH and Cortisol Responses to Naloxone Infusion in Patients with Functional Hypothalamic Amenorrhea (FHA): A Pilot Study" Endocrines 1, no. 1: 35-45. https://doi.org/10.3390/endocrines1010004