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Open AccessFeature PaperCommunication

Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction

1
Department of Gynecology and Obstetrics, Shanghai Jiao Tong University School of Medicine, Kongjiang Rd. 1665, Shanghai 200092, China
2
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, 81377 Munich, Germany
3
Department of Gynecology and Obstetrics, School of Medicine, Shanghai Jiao Tong University, Dongfang Rd. 1630, Shanghai 200127, China
4
Department of Gynecology and Obstetrics, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany
*
Author to whom correspondence should be addressed.
This paper is an extended version of Junyan Zhu’s PhD thesis, 2019.
These two authors contributed equally to this work.
Endocrines 2020, 1(1), 22-34; https://doi.org/10.3390/endocrines1010003
Received: 12 March 2020 / Revised: 1 May 2020 / Accepted: 4 May 2020 / Published: 6 May 2020
Among prostaglandins, Prostaglandin E2 (PGE2) (PGE2) is considered especially important for decidualization, ovulation, implantation and pregnancy. Four major PGE2 receptor subtypes, EP1, EP2, EP3, EP4, as well as peroxisome proliferator-activated receptors (PPARs), mediate various PGE2 effects via their coupling to distinct signaling pathways. This review summarizes up-to-date literatures on the role of prostaglandin E2 receptors in female reproduction, which could provide a broad perspective to guide further research in this field. PGE2 plays an indispensable role in decidualization, ovulation, implantation and pregnancy. However, the precise mechanism of Prostaglandin E2 (EP) receptors in the female reproductive system is still limited. More investigations should be performed on the mechanism of EP receptors in the pathological states, and the possibility of EP agonists or antagonists clinically used in improving reproductive disorders. View Full-Text
Keywords: prostaglandin E2 receptors (EPs); peroxisome proliferator-activated receptors (PPARs); endometrium; ovary; trophoblast prostaglandin E2 receptors (EPs); peroxisome proliferator-activated receptors (PPARs); endometrium; ovary; trophoblast
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MDPI and ACS Style

Ye, Y.; Lin, P.; Zhu, J.; Jeschke, U.; von Schönfeldt, V. Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction. Endocrines 2020, 1, 22-34. https://doi.org/10.3390/endocrines1010003

AMA Style

Ye Y, Lin P, Zhu J, Jeschke U, von Schönfeldt V. Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction. Endocrines. 2020; 1(1):22-34. https://doi.org/10.3390/endocrines1010003

Chicago/Turabian Style

Ye, Yao; Lin, Peng; Zhu, Junyan; Jeschke, Udo; von Schönfeldt, Viktoria. 2020. "Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction" Endocrines 1, no. 1: 22-34. https://doi.org/10.3390/endocrines1010003

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