Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction †
Abstract
:1. Introduction
2. EP and PPARγ Receptors Signaling
3. EP Receptors in the Endometrium
Endometriosis
4. EP Receptors in Ovarian Development
5. EP Receptors in the Trophoblast/Embryo
5.1. ECM Remodeling
5.2. Trophoblast Invasion
5.3. Pregnancy Related Diseases
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
PG | Prostaglandin |
AA | arachidonic acid |
PLA2 | phospholipase A2 |
PGG2 | prostaglandin G2 |
PGH2 | prostaglandin H2 |
COX | cyclooxygenase |
TXA2 | hromboxane A2 |
PGES | PGE synthase |
MRP4 | multidrug resistance protein 4 |
PGT | prostaglandin transporter |
GPCRs | G-protein coupled receptors |
EP | prostaglandin E receptor |
PPARs | Peroxisome proliferator activated receptors |
ECL2 | second extracellular loop |
TMVII | seventh transmembrane domain |
ICL2 | cond intercellular loop |
PKC | protein kinase C |
PLC | phospholipase C |
FAK | focal adhesion kinase |
cAMP | cyclic adenosine monophosphate |
CREB | response element binding protein |
HIF-1α | hypoxia-inducible factor-1α |
PI3K | phosphoinositide-3 kinase |
mTOR | mammalian target of rapamycin |
ERK | extracellular signal-regulated kinase |
EGR-1 | early growth response protein 1 |
AC | adenylyl cyclase |
RXR | retinoic acid receptor |
PPPE | peroxisome proliferator response element |
IL-8 | interleukin-8 |
RT-PCR | reverse transcription polymerase chain reaction |
ESCs | endometrial stromal cells |
Mφ | macrophages |
NK | natural killer |
FSH | follicle-stimulating hormone |
LH | luteinizing hormone |
BDNF | brain-derived neurotrophic factor |
GV | germinal vesicle |
hOMECs | human ovarian follicular endothelial cells |
EEC | endometrial epithelial cell |
TACE | tumor necrosis factor-alpha converting enzyme |
MT1-MMP | membrane-type 1 matrix metalloproteases |
HUVECs | Human umbilical vein endothelial cells |
ECM | extracellular matrix |
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Ye, Y.; Lin, P.; Zhu, J.; Jeschke, U.; von Schönfeldt, V. Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction. Endocrines 2020, 1, 22-34. https://doi.org/10.3390/endocrines1010003
Ye Y, Lin P, Zhu J, Jeschke U, von Schönfeldt V. Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction. Endocrines. 2020; 1(1):22-34. https://doi.org/10.3390/endocrines1010003
Chicago/Turabian StyleYe, Yao, Peng Lin, Junyan Zhu, Udo Jeschke, and Viktoria von Schönfeldt. 2020. "Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction" Endocrines 1, no. 1: 22-34. https://doi.org/10.3390/endocrines1010003