Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography
1
Department of Mechanical Science & Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2
Beckman Institute and Institute for Condensed Matter Theory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Karol Miller
Modelling 2020, 1(2), 225-241; https://doi.org/10.3390/modelling1020014
Received: 15 July 2020
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Revised: 8 December 2020
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Accepted: 8 December 2020
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Published: 14 December 2020
(This article belongs to the Section Modelling in Biology and Medicine)
Tissues of the brain, especially white matter, are extremely heterogeneous—with constitutive responses varying spatially. In this paper, we implement a high-resolution Finite Element (FE) head model where heterogeneities of white matter structures are introduced through Magnetic Resonance Elastography (MRE) experiments. Displacement of white matter under shear wave excitation is captured and the material properties determined through an inversion algorithm are incorporated in the FE model via a two-term Ogden hyper-elastic material model. This approach is found to improve model predictions when compared to experimental results. In the first place, mechanical response in the cerebrum near stiff structures such as the corpus callosum and corona radiata are markedly different compared with a homogenized material model. Additionally, the heterogeneities introduce additional attenuation of the shear wave due to wave scattering within the cerebrum.
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Keywords:
mTBI; MRI; MRE; brain wave dynamics; FE brain models
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MDPI and ACS Style
Madhukar, A.; Ostoja-Starzewski, M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling 2020, 1, 225-241. https://doi.org/10.3390/modelling1020014
AMA Style
Madhukar A, Ostoja-Starzewski M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling. 2020; 1(2):225-241. https://doi.org/10.3390/modelling1020014
Chicago/Turabian StyleMadhukar, Amit, and Martin Ostoja-Starzewski. 2020. "Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography" Modelling 1, no. 2: 225-241. https://doi.org/10.3390/modelling1020014
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