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Article

Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis

by
Anna E. Reinert
1,*,
Maria Bolshakova
2,
Alexander S. Wong
3 and
Victoria K. Cortessis
1,2
1
Department of Obstetrics & Gynecology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA
2
Department of Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA
3
Pardee RAND Graduate School, RAND Corporation, Santa Monica, CA 90401, USA
*
Author to whom correspondence should be addressed.
Reprod. Med. 2025, 6(3), 23; https://doi.org/10.3390/reprodmed6030023 (registering DOI)
Submission received: 30 June 2025 / Revised: 28 August 2025 / Accepted: 4 September 2025 / Published: 8 September 2025

Abstract

Background/Objectives: Legal access to cannabinoids is increasing, and patients with chronic pelvic pain from endometriosis were hypothesized to explore and find benefit from the use of marijuana for symptom management. A survey of women with endometriosis was conducted with the objective of characterizing their experience with marijuana for management of pelvic pain: exploring symptom benefit, characteristics of use, and factors contributing to use and discontinuation. Methods: A descriptive cross-sectional survey was undertaken using an anonymous online questionnaire. Participants were recruited from an outpatient gynecology clinic using endometriosis ICD-10 diagnostic codes, and from the Endometriosis Association mailing list. Results: Marijuana use for symptom relief was reported by 78 (32.2%) Endometriosis Association participants, and 58 (46.8%) clinic participants. Within both populations, marijuana was considered very or moderately effective by most users (68.0 to 75.9%). Legality of recreational and medicinal marijuana in the state of residence was strongly associated with use (OR 7.13 [95% CI: 2.57–19.8]). Among users specifying current or past use, discontinuation was reported by 45% (54 of 121), and most frequently attributed to non-clinical factors of legal/employment risk and obstacles to marijuana access; 64.8% of former users attributed discontinuation to non-clinical factors only. Lack of symptom relief from other clinical management was the most cited motivation for initiation (55.1% clinic, 39.7% EA users). Conclusions: Marijuana use is common among women with endometriosis and chronic, refractory pelvic pain. Legality and access appear to impact use and discontinuation. While legal access to marijuana is associated with increased use, marijuana obtained outside of legal routes is also commonly being used for symptom relief.
Keywords: endometriosis; pelvic pain; cannabis endometriosis; pelvic pain; cannabis

Share and Cite

MDPI and ACS Style

Reinert, A.E.; Bolshakova, M.; Wong, A.S.; Cortessis, V.K. Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis. Reprod. Med. 2025, 6, 23. https://doi.org/10.3390/reprodmed6030023

AMA Style

Reinert AE, Bolshakova M, Wong AS, Cortessis VK. Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis. Reproductive Medicine. 2025; 6(3):23. https://doi.org/10.3390/reprodmed6030023

Chicago/Turabian Style

Reinert, Anna E., Maria Bolshakova, Alexander S. Wong, and Victoria K. Cortessis. 2025. "Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis" Reproductive Medicine 6, no. 3: 23. https://doi.org/10.3390/reprodmed6030023

APA Style

Reinert, A. E., Bolshakova, M., Wong, A. S., & Cortessis, V. K. (2025). Self-Reported Use and Effectiveness of Marijuana for Pelvic Pain Among Women with Endometriosis. Reproductive Medicine, 6(3), 23. https://doi.org/10.3390/reprodmed6030023

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