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Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study

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Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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California Preterm Birth Initiative (PTBi-CA), University of California San Francisco (UCSF), San Francisco, CA 94158, USA
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San Diego Study of Outcomes in Mothers and Infants (SOMI), University of California San Diego (UCSD), La Jolla, CA 92093, USA
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Department of Obstetrics, Gynecology & Reproductive, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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Department of Pediatrics, University of California San Diego (UCSD), La Jolla, CA 92093, USA
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Degree Program in Bioinformatics, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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Department of Psychiatry, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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Department of Cardiology, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA 94158, USA
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Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98101, USA
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Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, 1900 9th Ave., Seattle, WA 98101, USA
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Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
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Maternal, Child and Adolescent Health Section, Epidemiology Unit, City and County of San Francisco Department of Public Health, San Francisco, CA 94102, USA
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Omics Data Automation, Inc. (ODA), Beaverton, OR 97005, USA
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Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213, USA
*
Author to whom correspondence should be addressed.
Reprod. Med. 2020, 1(2), 91-107; https://doi.org/10.3390/reprodmed1020007
Received: 25 June 2020 / Revised: 11 July 2020 / Accepted: 20 July 2020 / Published: 22 July 2020
The 2019 novel coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and worsen in many parts of the world. As the pandemic grows, it is especially important to understand how the virus and the pandemic are affecting pregnant women and infants. While early data suggested that being infected with the virus did not increase the risk of adverse pregnancy or infant outcomes, as more information has emerged, it has become clear that risks for some adverse pregnancy and infant outcomes are increased (e.g., preterm birth, cesarean section, respiratory distress, and hospitalization). The Healthy Outcomes of Pregnancy for Everyone in the time of novel coronavirus disease-19 (HOPE COVID-19) study is a multi-year, prospective investigation designed to better understand how the SARS-CoV-2 virus and COVID-19 impact adverse pregnancy and infant outcomes. The study also examines how the pandemic exacerbates existing hardships such as social isolation, economic destabilization, job loss, housing instability, and/or family member sickness or death among minoritized and marginalized communities. Specifically, the study examines how pandemic-related hardships impact clinical outcomes and characterizes the experiences of Black, Latinx and low-income groups compared to those in other race/ethnicity and socioeconomic stratum. The study includes two nested cohorts. The survey only cohort will enroll 7500 women over a two-year period. The survey+testing cohort will enroll 2500 women over this same time period. Participants in both cohorts complete short surveys daily using a mobile phone application about COVID-19-related symptoms (e.g., fever and cough) and complete longer surveys once during each trimester and at 6–8 weeks and 6, 12 and 18 months after delivery that focus on the health and well-being of mothers and, after birth, of infants. Participants in the survey+testing cohort also have testing for SARS-CoV-2 and related antibodies during pregnancy and after birth as well as testing that looks at inflammation and for the presence of other infections like Influenza and Rhinovirus. Study results are expected to be reported on a rolling basis and will include quarterly reporting for participants and public health partners as well as more traditional scientific reporting. View Full-Text
Keywords: pregnancy; 2019 novel coronavirus disease (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); preterm birth; intra-uterine-growth-restriction (IUGR); preeclampsia; cesarean section; infancy; newborn; neonatal pregnancy; 2019 novel coronavirus disease (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); preterm birth; intra-uterine-growth-restriction (IUGR); preeclampsia; cesarean section; infancy; newborn; neonatal
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MDPI and ACS Style

Jelliffe-Pawlowski, L.L.; Oltman, S.P.; Rand, L.; Scott, K.A.; Kuppermann, M.; Baer, R.; Bell, A.; Bandoli, G.; Costello, J.; Diamond-Smith, N.; Epel, E.; Jackson, R.; Jiang, F.; Karasek, D.A.; Lindan, C.; O’Leary, A.; Olgin, J.; Pantell, M.; Paquette, A.; Parikh, N.; Peyser, N.; Piao, X.; Prather, A.; Rutherford, G.; Ryckman, K.K.; Steurer-Muller, M.; Stookey, J.; Srinivasa, G.; Wright, H.; McCulloch, C.E.; Piening, B.; Rogers, E.E.; Chambers, C. Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study. Reprod. Med. 2020, 1, 91-107. https://doi.org/10.3390/reprodmed1020007

AMA Style

Jelliffe-Pawlowski LL, Oltman SP, Rand L, Scott KA, Kuppermann M, Baer R, Bell A, Bandoli G, Costello J, Diamond-Smith N, Epel E, Jackson R, Jiang F, Karasek DA, Lindan C, O’Leary A, Olgin J, Pantell M, Paquette A, Parikh N, Peyser N, Piao X, Prather A, Rutherford G, Ryckman KK, Steurer-Muller M, Stookey J, Srinivasa G, Wright H, McCulloch CE, Piening B, Rogers EE, Chambers C. Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study. Reproductive Medicine. 2020; 1(2):91-107. https://doi.org/10.3390/reprodmed1020007

Chicago/Turabian Style

Jelliffe-Pawlowski, Laura L.; Oltman, Scott P.; Rand, Larry; Scott, Karen A.; Kuppermann, Miriam; Baer, Rebecca; Bell, April; Bandoli, Gretchen; Costello, Jean; Diamond-Smith, Nadia; Epel, Elissa; Jackson, Rebecca; Jiang, Fei; Karasek, Deborah A.; Lindan, Christina; O’Leary, Allison; Olgin, Jeffrey; Pantell, Matt; Paquette, Alison; Parikh, Nisha; Peyser, Noah; Piao, Xianhua; Prather, Aric; Rutherford, George; Ryckman, Kelli K.; Steurer-Muller, Martina; Stookey, Jodi; Srinivasa, Ganapati; Wright, Hollis; McCulloch, Charles E.; Piening, Brian; Rogers, Elizabeth E.; Chambers, Christina. 2020. "Examining the Impact of the 2019 Novel Coronavirus and Pandemic-Related Hardship on Adverse Pregnancy and Infant Outcomes: Design and Launch of the HOPE COVID-19 Study" Reprod. Med. 1, no. 2: 91-107. https://doi.org/10.3390/reprodmed1020007

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