Scientific Production on Chemical Burns: A Bibliometric Analysis (1946–2024)
Abstract
1. Introduction
2. Materials and Methods
2.1. Conceptual Definition of Study Area
2.2. Identification of Document Population
2.3. Indicators Obtained
2.4. Bibliometric Analysis and Visualization
3. Results
3.1. Main Information
3.2. Publication Trends
3.3. Country Analysis
3.4. International Collaboration Between Countries
3.5. Journal Analysis
3.6. Author Analysis
3.7. Analysis of Most-Cited Articles
3.8. Analysis of MeSH Terms and Most Frequent Words
3.9. Analysis of Thematic MeSH Terms
3.10. Institutional Analysis
4. Discussion
- Regarding epidemiological contexts, in Bangladesh 68% of chemical burns are sulfuric acid attacks, a topic underrepresented in the global literature (only 2% of studies according to Mannan et al. [36]). This reflects the need to adapt research to local realities, as proposed by Forjuoh for low-income countries [2].
Limitations
- –
- Database bias:
- Methodological constraints:
- Population gaps:
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Countries | N Docs | % Docs | Dates | h-Index | Cit/Docs | Total Citations | Average Cit/Docs |
---|---|---|---|---|---|---|---|
USA | 790 | 20.04 | 1973–2024 | 559 | 24.19 | 18,534 | 23.50 |
China | 323 | 8.19 | 1981–2024 | 172 | 8.60 | 5849 | 18.10 |
UK | 261 | 6.62 | 1986–2024 | 358 | 22.67 | 3856 | 14.80 |
Turkey | 199 | 5.05 | 1973–2024 | 145 | 10.43 | 2758 | 13.90 |
India | 175 | 4.44 | 1973–2024 | 160 | 8.44 | 3768 | 21.50 |
France | 170 | 4.31 | 1973–2024 | 290 | 19.87 | 1930 | 11.40 |
Germany | 154 | 3.91 | 1973–2024 | 302 | 18.19 | 2206 | 14.30 |
Japan | 103 | 2.61 | 1973–2024 | 265 | 14.86 | 2623 | 25.50 |
Australia | 91 | 2.31 | 2005–2024 | 241 | 21.74 | 1372 | 15.10 |
Italy | 80 | 2.03 | 1985–2024 | 279 | 18.18 | 2737 | 34.20 |
Journal | n | % | JCR Category, Rank (Quartile) | IF | JCI | Start Year | Research Areas |
---|---|---|---|---|---|---|---|
Burns | 306 | 7.76 | Critical Care Medicine, 14/55, Q2 Dermatology, 25/94, Q2 Surgery, 43/292, Q1 | 3.2 | 0.91 | 1982 | Development of regenerative therapies, management of chronic sequelae, and surgical innovations; analysis of safety, tolerability, and functional outcomes in ocular reconstruction |
Cornea | 132 | 3.35 | Ophthalmology, 943/292 Q1 | 1.9 | 1.09 | 1998 | Limbal and amniotic membrane transplants; analysis of prognostic factors, acute management, and chronic complications; epidemiological studies; and post-traumatic visual rehabilitation |
Investigative Ophthalmology & Visual Science | 99 | 2.51 | Ophthalmology, 6/95, Q1 | 5.0 | 1.62 | 1977 | Murine/rabbit models of alkali burns, strategies, immune modulation, and tissue repair; transcriptomic/proteomic analysis to identify therapeutic targets |
Journal of Burn Care & Research | 75 | 1.90 | Critical Care Medicine, 36/55, Q3 Dermatology, 59/94, Q3 Surgery, 154/292, Q3 | 1.5 | 0.49 | 2006 | Etiology and epidemiology of chemical burns and systemic and neurological complications; differential diagnosis, innovative therapies, pediatric and occupational injuries, and socioeconomic impacts |
Journal of Pediatric Surgery | 68 | 1.72 | Pediatrics, 46/168, Q1 Surgery, 73/292, Q1 | 2.4 | 1.13 | 1971 | Management of esophageal strictures due to caustic ingestion; experimental studies in animal models; and prognostic analysis of esophageal motility and post-burn gastroesophageal reflux |
American Journal of Ophthalmology | 67 | 1.70 | Ophthalmology, 12/95, Q1 | 4.1 | 2.02 | 1946 | Reconstructive techniques and comparison of efficacy in acute injuries; late complications and experimental studies on innovative topical therapies |
Experimental Eye Research | 62 | 1.57 | Ophthalmology, 18/95, Q1 | 3.0 | 1.45 | 1972 | Corneal repair mechanisms; innovative therapies to modulate signaling pathways and epithelial regeneration; and evaluation of biomaterials and growth factors to restore corneal transparency |
Klinische Monatsblatter fur Augenheilkunde | 48 | 1.22 | Ophthalmology, 80/95, Q4 | 0.8 | 0.36 | 1972 | Emergency management, late complications, experimental therapies, epidemiology, immunology, and visual rehabilitation |
British Journal of Ophthalmology | 43 | 1.09 | Ophthalmology, 14/95, Q1 | 3.8 | 1.93 | 1952 | Epithelial and amniotic transplants for limbal stem cell deficiency and ocular surface reconstruction; anti-inflammatory and antiangiogenic strategies; management of severe chemical injuries; and prognostic factors |
Archives of Ophthalmology a | 39 | 0.98 | Ophthalmology, 3/57, Q1 | 4.4 | - | 1947 | Limbal cell and amniotic membrane transplants, ocular chemical burns, prevention of corneal ulceration, epithelial regeneration, and management of inflammation and neovascularization |
Rank | Category | N Docs | N Doc-Weighted Value | Rank | Category | N Docs | N Doc-Weighted Value |
---|---|---|---|---|---|---|---|
1 | Ophthalmology | 984 | 943 | 16 | Respiratory System | 84 | 36.92 |
2 | Surgery | 1185 | 719.83 | 17 | Anesthesiology | 40 | 35.58 |
3 | Medicine, General and Internal | 388 | 375.17 | 18 | Pathology | 52 | 35.17 |
4 | Dermatology | 547 | 260.67 | 19 | Medicine, Legal | 47 | 33.83 |
5 | Pediatrics | 325 | 218.83 | 20 | Multidisciplinary Sciences | 31 | 30 |
6 | Gastroenterology and Hepatology | 195 | 171.33 | 21 | Biochemistry and Molecular Biology | 48 | 25.42 |
7 | Critical Care Medicine | 430 | 151 | 22 | Cardiac and Cardiovascular Systems | 68 | 23.92 |
8 | Emergency Medicine | 168 | 135 | 23 | Veterinary Sciences | 22 | 16.5 |
9 | Otorhinolaryngology | 169 | 169 | 24 | Orthopedics | 29 | 16 |
10 | Toxicology | 139 | 105.5 | 25 | Obstetrics and Gynecology | 22 | 15.67 |
11 | Public, Environmental, and Occupational Health | 96 | 72.17 | 26 | Cell Biology | 30 | 14.52 |
12 | Pharmacology and Pharmacy | 75 | 52.17 | 27 | Allergy | 26 | 12.83 |
13 | Medicine, Research, and Experimental | 87 | 50.5 | 28 | Immunology | 20 | 10.17 |
14 | Dentistry, Oral Surgery, and Medicine | 55 | 50 | 29 | Environmental Sciences | 25 | 9.67 |
15 | Radiology, Nuclear Medicine, and Medical Imaging | 56 | 41.83 | 30 | Oncology | 16 | 9.6 |
Author | N Docs | h-Index | TCs | 1st Publication | Topics Covered |
---|---|---|---|---|---|
Reim M. (1) | 35 | 17 | 694 | 1973 | Ischemia in chemical burns; innovative treatments for severe burns; acute erosions; enzyme activity; metabolic therapies; biomarkers; and surgical procedures (artificial epithelium) [13] |
Sarfati E. (2) | 35 | 16 | 836 | 1984 | Management of digestive injuries following ingestion of corrosive substances; focus on adults with acute and chronic complications; and therapeutic strategies to prevent perforation and fibrosis [16] |
Celerier M. (3) | 32 | 10 | 493 | 1974 | Management of caustic esophagitis, potassium permanganate gastric injuries, and surgical techniques for severe burns; strategies for esophageal reconstruction and gastric/colon bypass [17] |
Pfister R. (4) | 30 | 19 | 960 | 1971 | Mechanisms of corneal repair and regeneration in caustic burns; collagenase inhibition and chemotactic agents to prevent ulceration and perforation; and antioxidant, anti-inflammatory, and modulatory therapies in experimental models [18] |
Cattan P. (5) | 23 | 15 | 687 | 2000 | Surgical treatment of digestive injuries due to caustic ingestion (total esophagogastrectomy and other techniques); focusing on tissue necrosis, perforations, and systemic complications to prevent strictures and fibrosis [19] |
Paterson C. (6) | 22 | 15 | 800 | 1973 | Ocular hypertensive response after chemical burns, such as changes in intraocular pressure and prostaglandin activity in aqueous humor; mechanisms of polymorphonuclear leukocyte infiltration and the effect of sodium citrate; and metalloproteinase inhibitor therapies to prevent corneal ulceration [20] |
Kochhar R. (7) | 21 | 11 | 791 | 1986 | Prediction and management of esophageal and gastric strictures; evaluation of esophageal transit times, chronic complications, and enteral nutrition in severe injuries [21] |
Basu S. (8) | 20 | 13 | 1159 | 2011 | Cultured autologous limbal epithelial transplants for recurrent ocular burns; penetrating keratoplasty after limbal transplantation; and combined techniques for chronic unilateral burns [22] |
Dohlman Ch. (9) | 20 | 15 | 792 | 1969 | Use of bonded contact lenses for epithelial protection and regeneration in chemical burns; management of inflammatory glaucoma after ocular trauma; visual rehabilitation in eyes with phthisis; and development of keratoprostheses for severe cases of corneal damage [23] |
Schrage N. (10) | 19 | 12 | 403 | 1991 | Ocular irrigation in chemical burns, impact of buffered solutions on corneal calcification, and use of amphoteric washes; diagnosis with microtrephine and acute management of chemical/thermal burns [24] |
Document | TCs | TCs/Year | NTCs | Document Type/Discipline | Research Topic |
---|---|---|---|---|---|
Pellegrini G. et al. Long-Term Restoration of Damaged Corneal Surfaces with Autologous Cultivated Corneal Epithelium. Lancet 1997, 349 (9057), 990–993, [25] | 1100 | 37.93 | 26.94 | Article/ general and internal medicine | Autologous transplant; stem cells; limbs; reconstruction and in vitro |
Rama P., et al. Limbal Stem-Cell Therapy and Long-Term Corneal Regeneration. N. Engl. J. Med. 2010, 363 (2), 147–155. doi: 10.1056/NEJMoa0905955, [26] | 884 | 55.25 | 23.66 | Article/general and internal medicine | Autologous limbal stem cell transplants; eye and skin burns |
Wagoner M.D. Chemical Injuries of the Eye: Current Concepts in Pathophysiology and Therapy. Surv. Ophthalmol. 1997, 41 (4), 275–313, [27] | 384 | 13.24 | 9.40 | Review/ophthalmology | Epidermal growth factor; conjunctival autograft transplantation; experimental alkali burns; epithelial basement membrane; and nasal mucosal transplantation |
Oh J.Y., et al. The Anti-Inflammatory and Anti-Angiogenic Role of Mesenchymal Stem Cells in Corneal Wound Healing Following Chemical Injury. Stem Cells 2008, 26 (4), 1047–1055, [28] | 312 | 17.33 | 13.05 | Article/cell biology, biotechnology, applied microbiology, oncology, and hematology | Dendritic cells; cytokine expression; T cells; differentiation; thrombopondin-1; inhibition; neovascularization; and grafts |
Meller D., et al. Amniotic Membrane Transplantation for Acute Chemical or Thermal Burns. Ophthalmology 2000, 107 (5), 980–989; discussion 990, [29] | 309 | 11.88 | 8.23 | Article/ophthalmology | Corneal surface reconstruction; ocular surface; limbal autograft; animal models; differentiation; and corneal perforation |
Zargar S.A., et al. The Role of Fiberoptic Endoscopy in the Management of Corrosive Ingestion and Modified Endoscopic Classification of Burns. Gastrointest. Endosc. 1991, 37 (2), 165–169, [30] | 297 | 8.49 | 14.32 | Article/gastroenterology and hepatology | Ingestion of caustics; injuries in children; and esophageal and stomach injuries |
Azuara-Blanco A., et al. Amniotic Membrane Transplantation for Ocular Surface Reconstruction. Br. J. Ophthalmol. 1999, 83 (4), 399–402, [31] | 296 | 10.96 | 13.66 | Article/ophthalmology | Innovative proposal for grafting techniques |
Tsai R.J., et al. Human Allograft Limbal Transplantation for Corneal Surface Reconstruction. Cornea 1994, 13 (5), 389–400, [32] | 296 | 9.25 | 14.5 | Article/ophthalmology | Transplant technique for corneal reconstruction |
Sangwan V.S., et al. Simple Limbal Epithelial Transplantation (SLET): A Novel Surgical Technique for the Treatment of Unilateral Limbal Stem Cell Deficiency. Br. J. Ophthalmol. 2012, 96 (7), 931–934, [33] | 288 | 20.6 | 9.34 | Article/ophthalmology | Transplantation; clinical results; culture; and cornea |
Ma Y, et al. Reconstruction of Chemically Burned Rat Corneal Surface by Bone Marrow-Derived Human Mesenchymal Stem Cells. Stem Cells 2006, 24 (2), 315–321, [34] | 282 | 14.1 | 12.05 | Article/cell biology, biotechnology, applied microbiology, oncology, and hematology | Amniotic membrane transplant; ocular surface; stromal cells; differentiation; and epithelium |
1946–1974 (n = 333) | 1975–1999 (n = 1495) | 2000–2024 (n = 2101) | Overall (n = 3929) | ||||||
---|---|---|---|---|---|---|---|---|---|
Rank | MeSH Heading | N Docs | % | N Docs | % | N Docs | % | N Docs | % |
1 | Eye Burns | 70 | 21.02 | 381 | 25.48 | 707 | 33.65 | 1158 | 29.47 |
2 | Esophageal Stenosis | 77 | 23.12 | 337 | 22.54 | 269 | 12.8 | 683 | 17.38 |
3 | Caustics | 59 | 17.72 | 189 | 12.64 | 411 | 19.56 | 659 | 16.77 |
4 | Esophagus | 68 | 20.42 | 251 | 16.79 | 212 | 10.09 | 531 | 13.51 |
5 | Cornea | 42 | 12.61 | 151 | 10.1 | 250 | 11.9 | 443 | 11.28 |
6 | Wound Healing | 23 | 6.91 | 118 | 7.89 | 255 | 12.14 | 396 | 10.08 |
7 | Sodium Hydroxide | 28 | 8.41 | 121 | 8.09 | 214 | 10.19 | 363 | 9.24 |
8 | Corneal Injuries | 19 | 5.71 | 113 | 7.56 | 207 | 9.85 | 339 | 8.63 |
9 | Alkalis | 23 | 6.91 | 107 | 7.16 | 205 | 9.76 | 335 | 8.53 |
10 | Corneal Diseases | 0 | 0 | 42 | 2.81 | 184 | 8.76 | 226 | 5.75 |
11 | Burns | 53 | 15.92 | 63 | 4.21 | 86 | 4.09 | 202 | 5.14 |
12 | Skin | 20 | 6.01 | 71 | 4.75 | 102 | 4.85 | 193 | 4.91 |
13 | Esophagoscopy | 29 | 8.71 | 92 | 6.15 | 68 | 3.24 | 189 | 4.81 |
14 | Stomach | 29 | 8.71 | 103 | 6.89 | 55 | 2.62 | 187 | 4.76 |
15 | Epithelium, Corneal | 0 | 0 | 11 | 0.74 | 165 | 7.85 | 176 | 4.48 |
16 | Visual Acuity | 4 | 1.2 | 32 | 2.14 | 138 | 6.57 | 174 | 4.43 |
17 | Postoperative Complications | 18 | 5.41 | 96 | 6.42 | 60 | 2.86 | 174 | 4.43 |
18 | Hydrofluoric Acid | 3 | 0.9 | 77 | 5.15 | 84 | 4 | 164 | 4.17 |
19 | Accidents, Occupational | 7 | 2.1 | 79 | 5.28 | 75 | 3.57 | 161 | 4.1 |
20 | Dilatation | 20 | 6.01 | 79 | 5.28 | 58 | 2.76 | 157 | 4 |
21 | Corneal Neovascularization | 0 | 0 | 6 | 0.4 | 144 | 6.85 | 150 | 3.82 |
22 | Limbus Corneae | 0 | 0 | 14 | 0.94 | 133 | 6.33 | 147 | 3.74 |
23 | Colon | 13 | 3.9 | 74 | 4.95 | 49 | 2.33 | 136 | 3.46 |
24 | Transplantation, Autologous | 22 | 6.61 | 37 | 2.47 | 72 | 3.43 | 131 | 3.33 |
25 | Skin Transplantation | 10 | 3 | 48 | 3.21 | 71 | 3.38 | 129 | 3.28 |
26 | Radiography | 37 | 11.11 | 65 | 4.35 | 27 | 1.29 | 129 | 3.28 |
27 | Therapeutic Irrigation | 16 | 4.8 | 48 | 3.21 | 61 | 2.9 | 125 | 3.18 |
28 | Esophagoplasty | 14 | 4.2 | 81 | 5.42 | 28 | 1.33 | 123 | 3.13 |
29 | Conjunctiva | 11 | 3.3 | 56 | 3.75 | 53 | 2.52 | 120 | 3.05 |
30 | Ophthalmic Solutions | 0 | 0 | 27 | 1.81 | 91 | 4.33 | 118 | 3 |
Affiliation | Country | Ranking (Percentile) a | Line of Research | ||||
---|---|---|---|---|---|---|---|
N | O | R | I | S | |||
Harvard University/ Harvard Medical School/ Harvard University Medical Affiliates | USA | 325 | 1 | 1 | 2 | 1 | Topics on the management of chemical burns; burns involving various chemicals on the skin, eyes, and esophagus; and the various specific surgical and clinical techniques for their management (first publication: 1974) |
Université Paris Cité | France | 121 | 2 | 2 | 12 | 2 | Treatment and management of chemical and caustic burns; diagnostic evaluation and experimental studies on wound healing and quality of life after internal injuries (first publication: 1974) |
Assistance Publique Hôpitaux Paris (APHP) | France | 118 | 1 | 1 | 10 | 1 | Chemical burn treatment; case analysis and epidemiological studies on substance ingestion and its effects on health; and experimental models and evaluation of risk factors associated with chemical burns (first publication: 1974) |
L. V. Prasad Eye Institute | India | 91 | 59 | 46 | 73 | 49 | Treatment and management of ocular chemical burns, including the use of conjunctival and amniotic membrane grafts; limbal stem cell transplantation; and specialty contact lenses (first publication: 1999) |
University of California System | USA | 78 | 1 | 1 | 7 | 1 | Importance of prevention and timely treatment of chemical burns, understanding specific injuries and their health implications (first publication: 1973) |
Chang Gung Memorial Hospital | China | 68 | 14 | 19 | 25 | 11 | They prioritize understanding chemical injuries, their management, and their impact on health, and developing new techniques and technologies to improve the treatment and reconstruction of affected tissues (first publication: 1988) |
Hopital Universitaire Saint-Louis—APHP | France | 68 | - | - | - | - | They emphasize the need for a multidisciplinary approach to the management of severe chemical injuries, including early evaluation and reconstruction of the esophagus and gastrointestinal tract, and consideration of various risk factors (first publication: 1974) |
Post Graduate Institute of Medical Education and Research, Chandigarh | India | 61 | - | - | - | - | Endoscopic techniques for managing chemical injuries in the respiratory and digestive tracts, also highlighting the need for long-term follow-up (first publication: 1979) |
Egyptian Knowledge Bank | Egypt | 59 | - | - | - | - | The treatment and prevention of chemical injuries in children, management of esophageal strictures, management of stomach injuries, and epidemiological data on burns in children (first publication: 1976) |
University of London | UK | 56 | 23 | 14 | 41 | 25 | Provides studies on various types of burns, including those involving chemical substances, iatrogenic injuries, oral and ocular injuries, and injuries caused by chemical ingestion (first publication: 1979) |
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Cueva-Ramírez, J.-E.; Gonzalez-Alcaide, G.; Belinchón-Romero, I.; Ramos-Rincon, J.-M. Scientific Production on Chemical Burns: A Bibliometric Analysis (1946–2024). Eur. Burn J. 2025, 6, 51. https://doi.org/10.3390/ebj6030051
Cueva-Ramírez J-E, Gonzalez-Alcaide G, Belinchón-Romero I, Ramos-Rincon J-M. Scientific Production on Chemical Burns: A Bibliometric Analysis (1946–2024). European Burn Journal. 2025; 6(3):51. https://doi.org/10.3390/ebj6030051
Chicago/Turabian StyleCueva-Ramírez, José-Enrique, Gregorio Gonzalez-Alcaide, Isabel Belinchón-Romero, and Jose-Manuel Ramos-Rincon. 2025. "Scientific Production on Chemical Burns: A Bibliometric Analysis (1946–2024)" European Burn Journal 6, no. 3: 51. https://doi.org/10.3390/ebj6030051
APA StyleCueva-Ramírez, J.-E., Gonzalez-Alcaide, G., Belinchón-Romero, I., & Ramos-Rincon, J.-M. (2025). Scientific Production on Chemical Burns: A Bibliometric Analysis (1946–2024). European Burn Journal, 6(3), 51. https://doi.org/10.3390/ebj6030051