Divulging the Complexities of Deep Partial- and Full-Thickness Burn Wounds Afflicted by Staphylococcus Aureus Biofilms in a Rat Burn Model
Abstract
1. Introduction
2. Materials and Methods
2.1. Bacterial Strain
2.2. Overview of Scald Burn Model
2.3. Bioburden Quantification
2.4. Gene Transcript Analysis
2.5. Histopathological Assessment
2.6. Blood Collection and Processing
2.7. Local Cytokine & Chemokine Panel
2.8. Danger Associated Molecular Patterns Analysis
2.8.1. Myeloperoxidase Activity
2.8.2. High Mobility Group Box-1
2.8.3. Hyaluronan
2.8.4. Complement C3
2.9. Statistical Analysis
3. Results
3.1. Bacterial Burden and Biofilm Formation
3.2. Pathological Assessment & MPO Activity
3.3. Local Cytokines
3.4. DAMPS
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Weaver, A.J., Jr.; Brandenburg, K.S.; Karna, S.L.R.; Olverson, C.; Leung, K.P. Divulging the Complexities of Deep Partial- and Full-Thickness Burn Wounds Afflicted by Staphylococcus Aureus Biofilms in a Rat Burn Model. Eur. Burn J. 2021, 2, 106-124. https://doi.org/10.3390/ebj2030009
Weaver AJ Jr., Brandenburg KS, Karna SLR, Olverson C, Leung KP. Divulging the Complexities of Deep Partial- and Full-Thickness Burn Wounds Afflicted by Staphylococcus Aureus Biofilms in a Rat Burn Model. European Burn Journal. 2021; 2(3):106-124. https://doi.org/10.3390/ebj2030009
Chicago/Turabian StyleWeaver, Alan J., Jr., Kenneth S. Brandenburg, S. L. Rajasekhar Karna, Christopher Olverson, and Kai P. Leung. 2021. "Divulging the Complexities of Deep Partial- and Full-Thickness Burn Wounds Afflicted by Staphylococcus Aureus Biofilms in a Rat Burn Model" European Burn Journal 2, no. 3: 106-124. https://doi.org/10.3390/ebj2030009
APA StyleWeaver, A. J., Jr., Brandenburg, K. S., Karna, S. L. R., Olverson, C., & Leung, K. P. (2021). Divulging the Complexities of Deep Partial- and Full-Thickness Burn Wounds Afflicted by Staphylococcus Aureus Biofilms in a Rat Burn Model. European Burn Journal, 2(3), 106-124. https://doi.org/10.3390/ebj2030009