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Open AccessFeature PaperArticle

Fluid-Structure Interaction Analysis of Subject-Specific Mitral Valve Regurgitation Treatment with an Intra-Valvular Spacer

1
Department of Osteopathic Manipulative Medicine, College of Osteopathic Medicine, New York Institute of Technology, Old Westbury Campus, Northern Boulevard, Old Westbury, NY 11568-8000, USA
2
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Technology Enterprise Park, Suite 200, 387 Technology Circle, Atlanta, GA 30313-2412, USA
3
Department of Mechanical Engineering, St. Martin’s University, 5000 Abbey Way SE, Lacey, WA 98503, USA
4
Department of Mechanical Engineering, University of Maine, 219 Boardman Hall, Orono, ME 04469-5711, USA
*
Author to whom correspondence should be addressed.
Prosthesis 2020, 2(2), 65-75; https://doi.org/10.3390/prosthesis2020007
Received: 1 May 2020 / Revised: 19 May 2020 / Accepted: 20 May 2020 / Published: 23 May 2020
(This article belongs to the Section Biotechnologies)
Mitral regurgitation imposes a significant symptomatic burden on patients who are not candidates for conventional surgery. For these patients, transcatheter repair and replacement devices are emerging as alternative options. One such device is an intravalvular balloon or spacer that is inserted between the mitral valve leaflets to fill the gap that gives rise to mitral regurgitation. In this study, we apply a large-deformation fluid-structure interaction analysis to a fully 3D subject-specific mitral valve model to assess the efficacy of the intra-valvular spacer for reducing mitral regurgitation severity. The model includes a topologically 3D subvalvular apparatus with unprecedented detail. Results show that device fixation and anchoring at the location of the subject’s regurgitant orifice is imperative for optimal reduction of mitral regurgitation. View Full-Text
Keywords: mitral valve; mitral regurgitation; mitral valve insufficiency; fluid-structure interaction mitral valve; mitral regurgitation; mitral valve insufficiency; fluid-structure interaction
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MDPI and ACS Style

Toma, M.; Einstein, D.R.; Bloodworth, C.H., IV; Kohli, K.; Cochran, R.P.; Kunzelman, K.S.; Yoganathan, A.P. Fluid-Structure Interaction Analysis of Subject-Specific Mitral Valve Regurgitation Treatment with an Intra-Valvular Spacer. Prosthesis 2020, 2, 65-75. https://doi.org/10.3390/prosthesis2020007

AMA Style

Toma M, Einstein DR, Bloodworth CH IV, Kohli K, Cochran RP, Kunzelman KS, Yoganathan AP. Fluid-Structure Interaction Analysis of Subject-Specific Mitral Valve Regurgitation Treatment with an Intra-Valvular Spacer. Prosthesis. 2020; 2(2):65-75. https://doi.org/10.3390/prosthesis2020007

Chicago/Turabian Style

Toma, Milan; Einstein, Daniel R.; Bloodworth, Charles H., IV; Kohli, Keshav; Cochran, Richard P.; Kunzelman, Karyn S.; Yoganathan, Ajit P. 2020. "Fluid-Structure Interaction Analysis of Subject-Specific Mitral Valve Regurgitation Treatment with an Intra-Valvular Spacer" Prosthesis 2, no. 2: 65-75. https://doi.org/10.3390/prosthesis2020007

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