Antibiotics in Dairy Production: Where Is the Problem?
Round 1
Reviewer 1 Report
Overall, this is a good review paper that summarizes and draws attention to other works surrounding the presence of antimicrobial residues in milk and dairy products. Its publication would be a positive addition to the literature for a variety of audiences, but mostly for non-experts.
There are several typographical or grammatical errors, a few of which listed below:
line 36 - "rise by 11.5% in 2030" - Ii believe this should read rise 11.5 % by 2030
line 86 - "intermammary" should be "intramammary"
line 101 - "goat" should be "goats"
line 104 - "he veterinarian" should be "the veterinarian"
line 124 - "since 1999 to 2019" should be "from 1999 to 2019"
line 163-164 - "them in the Table 2" should be "them in Table 2"
line 172 - "variables" should be "variable"
line 175 - "South American" should be "South America"
line 192 - "goat" should be "goats"
line 238 - "higher that 80%" should be "higher than 80%"
line 250 - spiking with them cow" should be "spiking them with cow"
line 275-276 - there is inconsistency with the spelling of oxytetracycline / oxitetracycline in Table 1 and the text (also line 341, 348, 351)
line 392 - "subcjet" should be "subject"
line 400 - "treated experimentally cows" should be "treated cows experimentally"
line 422 - I would use the term "exposure" rather than "exposition"
line 429 - the word "lead" should be "led"
line 435 - "A 23% of unpasteurized milk" should read " 23% of unpasteurized", although that begins the sentence with a number
line 437 - "found" should be "find"
line 503 - "specially" should be "especially"
line 504 - "especial" should be "special"
line 542 - "Figura 3" should be Figure 3"
line 550 - there seems to be a word or phrase missing after the word "are"
Author Response
Response to Reviewer 1
Thank you very much for your kind comments and suggestions to improve the manuscript.
Comments:
line 36 - "rise by 11.5% in 2030" - Ii believe this should read rise 11.5 % by 2030.
Done
line 86 - "intermammary" should be "intramammary"
Done
line 101 - "goat" should be "goats"
Done
line 104 - "he veterinarian" should be "the veterinarian"
Done
line 124 - "since 1999 to 2019" should be "from 1999 to 2019"
Done
line 163-164 - "them in the Table 2" should be "them in Table 2"
Done
line 172 - "variables" should be "variable"
Done
line 175 - "South American" should be "South America"
Done
line 192 - "goat" should be "goats"
Done
line 238 - "higher that 80%" should be "higher than 80%"
Done
line 250 - spiking with them cow" should be "spiking them with cow"
Done
line 275-276 - there is inconsistency with the spelling of oxytetracycline / oxitetracycline in Table 1 and the text (also line 341, 348, 351)
We have corrected all as “oxytetracycline”
line 392 - "subcjet" should be "subject"
Done
line 400 - "treated experimentally cows" should be "treated cows experimentally"
Done
line 422 - I would use the term "exposure" rather than "exposition"
Done
line 429 - the word "lead" should be "led"
Done
line 435 - "A 23% of unpasteurized milk" should read " 23% of unpasteurized", although that begins the sentence with a number
Done
line 437 - "found" should be "find"
Done
line 503 - "specially" should be "especially"
Done
line 504 - "especial" should be "special"
Done
line 542 - "Figura 3" should be Figure 3"
Done
line 550 - there seems to be a word or phrase missing after the word "are"
The sentence has been changed.
In addition, all authors have reviewed the manuscript trying to detect other typographical or grammatical errors. I hope we have corrected them all.
Reviewer 2 Report
Authors made a thorough and up –t date review on a topic of big interest. The presentation of this work in the submitted paper needs improvement.
More specific comments:
Table 1. This table is not mentioned in the text. Also Doxycycline instead of Doxyicline
L73. This should be Table 2, content of table 1 is different.
L86-87: needs improvement in language, it is not clear
L150-159: It would be better to use the word countries and not states, especially when talk about European countries.
L172: variable
L179: double “in”
L269-271: needs improvement in language, it is not clear
L289: research instead of researches
L296: new section is number 4, but there is no 3 earlier
L532: environment
L542: figure in English
Author Response
Thank you very much for your kind comments and suggestions.
Comments
Table 1. This table is not mentioned in the text. Also Doxycycline instead of Doxyicline
In fact, it was mentioned on line 74. Nevertheless, we have added a new sentence to explain its content.
L73. This should be Table 2, content of table 1 is different.
As we have answered in the previous question, a new sentence explains the content of Table 1.
L86-87: needs improvement in language, it is not clear.
We have modified the sentences between lines 86-88 trying to make them better understood. This modification has meant that we have to exchange references 18 and 19. This change has also been extended to the entire text.
L150-159: It would be better to use the word countries and not states, especially when talk about European countries.
We have continued to retain the word "state", precisely in the case of Europeans, where no one doubts that they are such. In the case of other continents (and in tables 2 and 3) we have used the word "territory", since the meaning of the word "state" is not so well defined in those cases, and because it is not for us to decide whether those territories are countries, nations, entities within which there are different nations, etc.
Perhaps, this can be taken as a political question that is beyond the scientific character of the manuscript. However, it is a sensitive issue for some of the authors who are legally affiliated with "Spain" even though we do not recognize it as our country.
L172: variable
Corrected
L179: double “in”
Corrected
L269-271: needs improvement in language, it is not clear
We have modified the sentence trying to make it better understood
L289: research instead of researches
Corrected
L296: new section is number 4, but there is no 3 earlier
We have corrected the number of this section and the following ones.
L532: environment
Corrected
L542: figure in English
Corrected
Reviewer 3 Report
this paper reviews and discuss the use of antibiotics in dairy production and potential issues that arises due to these residues and how they affect environmental and human health. The article is written well and easy to read. The sub-topics were discussed thoroughly however the conclusion does not answer to the last sub-topic which is " where is the problem?" The authors concluded that its mainly in developing countires with laxing regulation but then what else? Hopefully authors could add alittle bit more on what other suggested steps to be taken to curb this issue.
Author Response
Thank you very much for your kind comments and suggestion to improve the manuscript.
We have included new ideas in the “Conclusions” section trying to respond to this suggestion.
We believe that the section now reflects fairly well what can be concluded from the current state of the problem and also outlines some steps that can be taken to curb this problem.
