Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles
Abstract
:1. Introduction
2. Materials and Methods
3. Results and Discussion
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Entry | Catalyst (mol%) | Solvent | Temperature (oC) | Time (h) | Yield (%) 2 |
---|---|---|---|---|---|
1 | CuCl2 (20) | DCE | 80 | 10 | 34 |
2 | CuBr2 (20) | DCE | 80 | 10 | 41 |
3 | CuBr (20) | DCE | 80 | 10 | 28 |
4 | CuBr2 (30) | DCE | 80 | 10 | 40 |
5 | CuBr2 (10) | DCE | 80 | 10 | 54 |
6 | CuBr2 (10) | CHCl3 | 60 | 10 | 48 |
7 | CuBr2 (10) | 1,4-dioxane | 80 | 10 | 51 |
8 | CuBr2 (10) | toluene | 80 | 10 | 30 |
9 | CuBr2 (10) | CH3CN | 80 | 10 | trace |
10 | CuBr2 (10) | THF | 80 | 10 | 31 |
11 | CuBr2 (10) | petroleum ether | 80 | 10 | 57 |
12 | CuBr2 (10) | n-heptane | 80 | 10 | 55 |
13 | CuBr2 (10) | n-hexane | 80 | 10 | 59 |
14 | CuBr2 (10)/TFA (20) | n-hexane | 80 | 10 | 76 |
15 | CuBr2 (10)/AcOH (20) | n-hexane | 80 | 10 | 70 |
16 | CuBr2 (10)/conc.HCl (20) | n-hexane | 80 | 10 | 63 |
17 | CuBr2 (10)/TFA (10) | n-hexane | 80 | 10 | 73 |
18 | CuBr2 (10)/TFA (30) | n-hexane | 80 | 10 | 69 |
19 | CuBr2 (10)/TFA (20) | n-hexane | 70 | 10 | 70 |
20 | CuBr2 (10)/TFA (20) | n-hexane | 90 | 10 | 71 |
21 | CuBr2 (10)/TFA (20) | n-hexane | 80 | 8 | 66 |
22 | CuBr2 (10)/TFA (20) | n-hexane | 80 | 12 | 72 |
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Zhang, R.; Huang, L.; Gu, A.; Feng, H. Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles. Chemistry 2025, 7, 19. https://doi.org/10.3390/chemistry7010019
Zhang R, Huang L, Gu A, Feng H. Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles. Chemistry. 2025; 7(1):19. https://doi.org/10.3390/chemistry7010019
Chicago/Turabian StyleZhang, Rongkang, Liliang Huang, Aiguo Gu, and Huangdi Feng. 2025. "Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles" Chemistry 7, no. 1: 19. https://doi.org/10.3390/chemistry7010019
APA StyleZhang, R., Huang, L., Gu, A., & Feng, H. (2025). Copper-Catalyzed Four-Component A3-Based Cascade Reaction: Facile Synthesis of 3-Oxetanone-Derived Spirocycles. Chemistry, 7(1), 19. https://doi.org/10.3390/chemistry7010019