Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of β-Carboline Derivatives
2.2. Biological Screening
2.3. Docking Studies of Designed Compounds
3. Results and Discussion
3.1. Biological Screening Results
3.2. Docking Results
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Compound No. | R1 | R2 |
---|---|---|
1 | ||
2 | ||
3 | ||
4 | ||
5 | ||
6 | ||
7 | ||
8 | ||
9 | ||
10 | ||
11 | ||
12 | ||
13 | ||
14 |
Compound No. | Growth Inhibitory Effects, GI50 (µM) | Dock Score (G-Score) | |
---|---|---|---|
HepG2 Cell Line | A549 Cell Line | ||
1 | 8.14 | 7.21 | 4.15 |
2 | 8.34 | 8.87 | 4.48 |
3 | 8.73 | 8.22 | 4.98 |
4 | 0.94 | 4.10 | 6.52 |
5 | 8.64 | 8.05 | 4.39 |
6 | >100 | >100 | 3.27 |
7 | >100 | >100 | 3.98 |
8 | 8.12 | 7.35 | 4.38 |
9 | 0.16 | 0.14 | 7.28 |
10 | 0.69 | 6.76 | 6.21 |
11 | 5.81 | 6.52 | 5.03 |
12 | 7.61 | 4.22 | 4.12 |
13 | >100 | >100 | 4.05 |
14 | 1.54 | 1.42 | 6.17 |
Adriamycin | 0.1 | 0.1 |
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Chourasiya, R.K.; Agrawal, R.K.; Vaidya, A. Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation. Chemistry 2022, 4, 1395-1406. https://doi.org/10.3390/chemistry4040091
Chourasiya RK, Agrawal RK, Vaidya A. Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation. Chemistry. 2022; 4(4):1395-1406. https://doi.org/10.3390/chemistry4040091
Chicago/Turabian StyleChourasiya, Ravindra Kumar, Ram Kishore Agrawal, and Ankur Vaidya. 2022. "Promising Anticancer Activity of β-Carboline Derivatives: Design, Synthesis, and Pharmacological Evaluation" Chemistry 4, no. 4: 1395-1406. https://doi.org/10.3390/chemistry4040091