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Amino Acids and Peptides as Versatile Ligands in the Synthesis of Antiproliferative Gold Complexes

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Faculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia
2
Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia
*
Authors to whom correspondence should be addressed.
In Honor of Professor Bernd Giese on the Occasion of His 80th Birthday.
Chemistry 2020, 2(2), 203-218; https://doi.org/10.3390/chemistry2020013
Received: 6 March 2020 / Revised: 20 March 2020 / Accepted: 24 March 2020 / Published: 27 March 2020
Gold complexes have been traditionally employed in medicine, and currently, some gold(I) complexes, such as auranofin, are clinically used in the treatment of rheumatoid arthritis. In the last decades, both gold(I) and gold(III) complexes with different types of ligands have gained considerable attention as potential antitumor agents, showing superior activity both in vitro and in vivo to some of the clinically used agents. The present review article summarizes the results achieved in the field of synthesis and evaluation of gold complexes with amino acids and peptides moieties for their cytotoxicity. The first section provides an overview of the gold(I) complexes with amino acids and peptides, which have shown antiproliferative activity, while the second part is focused on the activity of gold(III) complexes with these ligands. A systematic summary of the results achieved in the field of gold(I/III) complexes with amino acids and peptides could contribute to the future development of metal complexes with these biocompatible ligands as promising antitumor agents. View Full-Text
Keywords: gold complexes; amino acids; peptides; cytotoxicity gold complexes; amino acids; peptides; cytotoxicity
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Andrejević, T.P.; Glišić, B.Đ.; Djuran, M.I. Amino Acids and Peptides as Versatile Ligands in the Synthesis of Antiproliferative Gold Complexes. Chemistry 2020, 2, 203-218.

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