Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms
Abstract
:1. Introduction
2. ER-Associated UPR Activation and IBD
2.1. IRE1–XBP1 Signaling in IECs and Myeloid Cells
2.2. PERK–eIF2α–CHOP Signaling in IECs and Myeloid Cells
2.3. ATF6 Signaling in IECs and Myeloid Cells
3. Mitochondria-Associated UPR Activation and IBD
3.1. MitoUPR Signaling in IECs and Myeloid Cells
3.2. Mitochondria in the Pathogenesis of IBD
4. Therapeutic Implications Targeting UPR Restoration
5. Conclusion and Future Perspectives
Funding
Acknowledgments
Conflicts of Interest
References
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Ranjan, K. Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms. Gastrointest. Disord. 2020, 2, 246-266. https://doi.org/10.3390/gidisord2030024
Ranjan K. Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms. Gastrointestinal Disorders. 2020; 2(3):246-266. https://doi.org/10.3390/gidisord2030024
Chicago/Turabian StyleRanjan, Kishu. 2020. "Intestinal Immune Homeostasis and Inflammatory Bowel Disease: A Perspective on Intracellular Response Mechanisms" Gastrointestinal Disorders 2, no. 3: 246-266. https://doi.org/10.3390/gidisord2030024