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Vaccination in Inflammatory Bowel Disease: Utility and Future Perspective

1
General Practitioner Limbiate (Monza Brianza), ATS Lecco-Brianza, 20812 Limbiate, Italy
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School of Specialization in Hygiene and Preventive Medicine, University of Tor Vergata, 00133 Rome, Italy
3
Department of Obstetrics and Gynecology, Campus Bio-Medico University, 00128 Rome, Italy
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Institute of Pathology, Spedali Civili Brescia, 25123 Brescia, Italy
*
Author to whom correspondence should be addressed.
Gastrointest. Disord. 2020, 2(2), 175-192; https://doi.org/10.3390/gidisord2020019
Received: 21 May 2020 / Revised: 15 June 2020 / Accepted: 16 June 2020 / Published: 23 June 2020
Inflammatory bowel disease (IBD) is an immune-mediated disease, which often require lifetime treatment with immunomodulators and immunosuppressive drugs. Both IBD and its treatments are associated with an increased risk of infectious disease and mortality. Several of these diseases are vaccine preventable and could be avoided, reducing morbidity and mortality. However, vaccination rates among patients with IBD are lower than in the general population and both patients and doctors are not fully aware of the problem. Education campaigns and well planned vaccination schemes are necessary to improve vaccination coverage in patients with IBD. Immunomodulators and immunosuppressive drugs may reduce the seroprotection levels. For this reason, new vaccination schemes are being studied in patients with IBD. It is therefore important to understand which and when vaccines can be administrated based on immunocompetence or immunosuppression of patients. Usually, live-attenuated vaccines should be avoided in immunosuppressed patients, so assessing vaccination status and planning vaccination before immunosuppressive treatments are pivotal to reduce infection risk. The aim of this review is to increase the awareness of the problem and provide a quick reference for vaccination plan tailoring, especially for gastroenterologists and primary care physicians, who have the skills and knowledge to implement vaccination strategies. View Full-Text
Keywords: vaccinations; inflammatory bowel disease; prevention vaccinations; inflammatory bowel disease; prevention
MDPI and ACS Style

Casella, G.; Ingravalle, F.; Ingravalle, A.; Monti, C.; Bonetti, F.; De Salvatore, F.; Villanacci, V.; Limonta, A. Vaccination in Inflammatory Bowel Disease: Utility and Future Perspective. Gastrointest. Disord. 2020, 2, 175-192.

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