Associations between the Presence of Granulomata and Disease Phenotype and Outcomes in Children Diagnosed with Crohn’s Disease
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Data Management
2.3. Disease Outcome Parameters
2.4. Data Analysis
3. Results
3.1. Patient Population
3.2. Disease Phenotype and Outcomes According to the Presence or Absence of Granuloma
3.3. Nutrition
4. Discussion
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Overall Cohort (n = 94) | Granuloma Positive (n = 49) | Granuloma Negative (n = 45) | Significance | ||||
---|---|---|---|---|---|---|---|
Gender (Male) | 49 | (52.1) | 29 | (59.2) | 20 | (40.8) | NS |
Age at diagnosis: | |||||||
A1a (0 < 10 yrs) | 22 | (23.4) | 8 | (16.3) | 11 | (24.4) | NS |
A1b (10 < 17 yrs) | 72 | (76.6) | 41 | (83.7) | 34 | (75.5) | NS |
Disease location at diagnosis: | |||||||
L1 ileum | 18 | (19.1) | 4 | (8.2) | 14 | (31.1) | p = 0.005 |
L2 colonic | 24 | (25.5) | 15 | (30.6) | 9 | (20.0) | NS |
L3 ileocolonic | 50 | (53.2) | 30 | (61.2) | 21 | (46.7) | NS |
L4 isolated upper gut | 1 | (1.1) | 0 | (0.0) | 1 | (2.2) | NS |
Upper gut involvement modifier | 40 | (42.6) | 26 | (53.1) | 14 | (31.1) | p = 0.032 |
Disease behaviour: | |||||||
B1 non-stricturing non-penetrating | 70 | (73.4) | 34 | (69.4) | 36 | (80.0) | NS |
B2 stricturing | 19 | (20.2) | 10 | (20.4) | 9 | (20.0) | NS |
B3 penetrating | 5 | (6.4) | 5 | (10.2) | 0 | (0.0) | NS |
B2B3 stricturing and penetrating | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | - |
p perianal modifier | 54 | (57.4) | 32 | (65.3) | 22 | (48.8) | NS |
Extra-intestinal manifestation at diagnosis (yes) | 26 | (27.7) | 14 | (28.6) | 12 | (26.7) | NS |
Surgery (yes) | 33 | (35.1) | 19 | (38.8) | 14 | (31.1) | NS |
Ever used: | |||||||
Biologics | 36 | (38.3) | 24 | (48.9) | 12 | (26.7) | p = 0.026 |
Immunomodulators | 83 | (88.3) | 48 | (97.9) | 35 | (77.8) | p = 0.002 |
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Appleton, L.; Watt, E.; Jagger, F.; Hansen, R.; Gearry, R.B.; Day, A.S. Associations between the Presence of Granulomata and Disease Phenotype and Outcomes in Children Diagnosed with Crohn’s Disease. Gastrointest. Disord. 2020, 2, 164-170. https://doi.org/10.3390/gidisord2020017
Appleton L, Watt E, Jagger F, Hansen R, Gearry RB, Day AS. Associations between the Presence of Granulomata and Disease Phenotype and Outcomes in Children Diagnosed with Crohn’s Disease. Gastrointestinal Disorders. 2020; 2(2):164-170. https://doi.org/10.3390/gidisord2020017
Chicago/Turabian StyleAppleton, Laura, Euan Watt, Fiona Jagger, Richard Hansen, Richard B. Gearry, and Andrew S. Day. 2020. "Associations between the Presence of Granulomata and Disease Phenotype and Outcomes in Children Diagnosed with Crohn’s Disease" Gastrointestinal Disorders 2, no. 2: 164-170. https://doi.org/10.3390/gidisord2020017