Role of Gastric Emptying in Symptoms of Gastroparesis
Abstract
:1. Introduction
2. Symptoms of Gastroparesis
3. Assessment of Gastric Emptying
3.1. Gastric Emptying Scintigraphy
3.2. Gastric Emptying Breath Testing
3.3. Wireless Motility Capsule
3.4. Ultrasonography
3.5. Gastric Magnetic Resonance Imaging
4. Role of Gastric Emptying in Symptoms of Gastroparesis
5. Conclusions
Author Contributions
Conflicts of Interest
References
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Methods to Assess Gastric Emptying | Advantages | Disadvantages |
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Gastric Emptying Scintigraphy |
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Gastric Emptying Breath Testing |
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Wireless Motility Capsule |
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Ultrasonography |
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Magnetic Resonance Imaging |
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First Author, Year | Study Design | Sample Size | Assessment of GE | Findings |
---|---|---|---|---|
Nowak et al., 1995 [45] | Pts with insulin dependent diabetes | 31 pts | GES | Pts with N, V and ES had more delayed GE |
Stanghellini et al., 1996 [44] | Pts with FD | 343 pts | GES | Delayed GE associated with severe PPF and V |
Tack et al., 1998 [43] | Pts with FD | 40 pts, 35 HVs | GEBT | Association between presence of severe N and delayed GE |
Perri et al., 1998 [41] | Consecutive pts with dyspeptic Sx | 304 pts | GEBT | Delayed GE associated with higher severity of PPF, N and V |
Cuomo et al., 2001 [46] | Pts with dyspeptic Sx | 52 pts | GES | Early satiety and bloating correlated with GE |
Stanghelleni et al., 2002 [47] | IBS pts with dyspeptic Sx | 146 pts | GES | PPF, N associated with delayed GE |
Fischler et al., 2003 [42] | Consecutive pts with (Rome II) FD | 438 pts | GEBT | Delayed GE associated with N, V, PPF and early satiety |
Stanghelleni et al., 2003 [58] | Consecutive pts with upper GI Sx | 327 pts | GES | PPF and B associated with delayed GE |
Ron et al., 2011 [48] | Consecutive pts referred for GEBT | 111 pts | GEBT | Early satiety associated with delayed GE |
Sfarti et al., 2010 [49] | Patients with type 1 DM | 69 pts, 40 HVs | GEBT | Delayed GE correlated with B and upper AP |
Marie et al., 2012 [50] | Consecutive pts with SSc | 57 pts | GEBT | Correlation between severity of GI Sx and delay in GE |
Ardila-Hani et al., 2013 [51] | Pts with Sx of Gp undergoing GES | 325 pts | GES | Gp Sx correlated with different retention times, but not with T1/2 |
Salles Junior et al., 2013 [52] | ESRD pts undergoing HD | 34 pts | GEBT | Dyspepsia scores correlated with T1/2 |
Boltin et al., 2014 [53] | Pts with dyspeptic Sx referred for GES | 193 pts | GES | V, dysphagia predicted delayed GE in diabetic and nondiabetic Gp pts. |
DiBaise et al., 2016 [54] | Consecutive pts with dyspeptic Sx | 266 pts | GES | Higher severity of N, V and PPF in pts with delayed GE |
Mori et al., 2017 [55] | Pts with FD | 126 pts, 52 HVs | GEBT | Higher severity of reflux Sx in female pts with delayed GE |
Park et al., 2017 [56] | Pts with functional GI Sx | 1287 pts | GES | N and V more prevalent in patients with delayed GE |
Parkman et al., 2017 [67] | Pts with Gp | 198 | GES | ES and PPF associated with GE |
Vanheel et al., 2017 [57] | Pts with FD as per Rome III criteria | 560 pts | GEBT | GE associated with N |
Vijayvargiya et al., 2019 [66] | Systematic review and meta-analysis | 6287 pts | GES or GEBT | Associations of GE with severities of N, V, AP, and ES/fullness. |
First Author, Year | Study Design | Sample Size | Assessment of Gastric Emptying | Conclusions |
---|---|---|---|---|
Talley et al., 2001 [59] | Pts with dyspeptic Sx | 708 pts | GEBT | No correlation between T1/2 and severity of Sx |
Talley et al., 2006 [62] | Pts with (Rome II) FD | 864 pts | GES | No association of delayed GE with AP, ES, N or B; only weak association with PPF |
Karamanolis et al., 2007 [64] | Pts with idiopathic Gp | 58 pts | GES | Overall Sx severity did not correlate with GE |
Cherian et al., 2010 [63] | Pts with Sx of Gp | 68 pts | GES | AP severity did not correlate with GE |
Pasricha et al., 2011 [60] | Pts with chronic N and V | 425 pts | GES | Total Gp cardinal Sx index scores did not correlate with GE. Sx severities similar between pts with delayed and normal GE. |
Janssen et al., 2013 [68] | Meta-regression analysis | 480 pts | GES, GEBT, ultrasound, radiopaque markers | No relationship between improvement of Sx and GE using different drugs for Gp. |
Anudeep et al., 2016 [61] | Pts with T2DM for ≥5 years) | 140 pts, 30 HVs | GES | No correlation between Sx of Gp and delayed GE. |
Jehangir et al., 2018 [6] | Consecutive pts with Sx of Gp | 357 pts | GES | Symptom severities similar between patients with delayed and normal GE. |
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Jehangir, A.; Parkman, H.P. Role of Gastric Emptying in Symptoms of Gastroparesis. Gastrointest. Disord. 2019, 1, 391-402. https://doi.org/10.3390/gidisord1040032
Jehangir A, Parkman HP. Role of Gastric Emptying in Symptoms of Gastroparesis. Gastrointestinal Disorders. 2019; 1(4):391-402. https://doi.org/10.3390/gidisord1040032
Chicago/Turabian StyleJehangir, Asad, and Henry P. Parkman. 2019. "Role of Gastric Emptying in Symptoms of Gastroparesis" Gastrointestinal Disorders 1, no. 4: 391-402. https://doi.org/10.3390/gidisord1040032