Next Article in Journal
Assessment of the Acute Effects of Carbonated Beverage Consumption on Symptoms and Objective Markers of Gastric Reflux
Next Article in Special Issue
Regulation of Antimicrobial Pathways by Endogenous Heat Shock Proteins in Gastrointestinal Disorders
Previous Article in Journal
Intrabolus Pressure Has Better Correlation Than Eosinophilia with Dysphagia Severity in Fibrostenotic Eosinophilic Esophagitis: A Pilot Study
Article Menu

Export Article

Open AccessReview
Gastrointest. Disord. 2018, 1(1), 15-29; https://doi.org/10.3390/gidisord1010003

CCR6–CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease

School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7250, Australia
*
Author to whom correspondence should be addressed.
Received: 17 July 2018 / Revised: 19 August 2018 / Accepted: 19 August 2018 / Published: 21 August 2018
Full-Text   |   PDF [719 KB, uploaded 21 August 2018]   |  

Abstract

Inflammatory bowel disease (IBD) has evoked significant interest in human immunobiology given its tactical immune evasion methodologies resulting in acute immune destabilization. IBD comprising Crohn’s disease and Ulcerative colitis manifests as chronic inflammation in the gut mucosa, leading to complexities involving immune dysregulation in the T helper lymphocyte arm, effecting disease pathogenicity. The mucosa of the alimentary canal is constantly exposed to a myriad of food antigens and luminal microorganisms for which a consistent host-protective mechanism is operative in healthy people. Lowered mucosal immune expression which allows penetration of the epithelial barrier by infective pathogenic microbes elicits both innate and adaptive immune responses in the gut, culminating in aberrant intestinal inflammation. Interestingly, the IBD leukocyte repertoire is significantly entwined with chemokine-assisted chemotactic navigation into the sites of inflammation, which is also thought to generate favorable immune-suppressive responses. The functions of the cognate chemokine receptor, CCR6, which binds with its unique ligand CCL20, are expected to tilt the balance between upregulation of homeostatic tolerance and inflammatory pathophysiology. This review aims to critically examine the CCR6-driven immune pathways: TH1/TH2, TH1/TH17, TH17/Treg, IL-23/IL-17, Akt/ERK-1/2, ILC3, and TH9/TH2 for systematic investigation of its underlying mechanisms in the future and to underpin its importance in resolving IBD pathology. Thus, CCR6 occupies an exclusive position in gut immunology which renders it an invaluable therapeutic tool for the production of novel medicaments to treat IBD. View Full-Text
Keywords: CCR6; CCL20; TH17 cells; regulatory Treg cells; Inflammatory Bowel Disease; immunologic pathways CCR6; CCL20; TH17 cells; regulatory Treg cells; Inflammatory Bowel Disease; immunologic pathways
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ranasinghe, R.; Eri, R. CCR6–CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease. Gastrointest. Disord. 2018, 1, 15-29.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Gastrointest. Disord. EISSN 2624-5647 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top