Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals
Abstract
:1. Introduction
2. Results
2.1. Polygenic Risk Scores for the FINRISK Cohorts
2.2. Validation of the PRSs in Health 2000/2011 Cohort
3. Discussion
4. Materials and Methods
4.1. GWAS Summary Statistics
4.2. Target Data
4.3. Assessing Sleep Traits
4.4. Generating Risk Scores
4.5. Estimating the Explanatory Power of the Risk Scores
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Sleep Duration | Chronotype | Insomnia | |
---|---|---|---|
FINRISK ‘92 | unavailable | unavailable | Do you suffer from insomnia?
|
FINRISK ‘97 | unavailable | unavailable | Do you suffer from insomnia?
|
FINRISK ‘02 | unavailable | unavailable | Do you suffer from insomnia?
|
FINRISK ‘07 | How many hours on average do you sleep in 24 h?
| There are so-called “morning people” (early to rise, early to bed) and “evening people” (late to rise, late to bed). Which are you?
| Do you suffer from insomnia?
|
FINRISK ’12 | How many hours on average do you sleep in 24 h?
| There are so-called “morning people” (early to rise, early to bed) and “evening people” (late to rise, late to bed). Which are you?
| Do you suffer from insomnia?
|
Health 2000 | How many hours on average do you sleep in 24 h?
| unavailable | Sleeping
|
Health 2011 | How many hours on average do you sleep in 24 h?
| unavailable | Sleeping
|
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PRS in Linear Model | PRS in Logistic Model | |||||
---|---|---|---|---|---|---|
N | R2 | p | N | pR2 | p | |
Chronotype | 8530 | 0.021 | <0.001 | 2993 | 0.033 | <0.001 |
Sleep duration | 7647 | 0.004 | <0.001 | 2016 | 0.010 | <0.001 |
Insomnia | - | - | - | 15,843 | 0.003 | <0.001 |
PRS in Linear Model | PRS in Logistic Model | |||||
---|---|---|---|---|---|---|
N | R2 | p | N | pR2 | p | |
Sleep duration | 6389 | 0.004 | <0.001 | 1812 | 0.008 | <0.001 |
Insomnia | - | - | - | 3335 | 0.003 | 0.03 |
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Perkiö, A.; Merikanto, I.; Kantojärvi, K.; Paunio, T.; Sinnott-Armstrong, N.; Jones, S.E.; Ollila, H.M. Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals. Clocks & Sleep 2023, 5, 10-20. https://doi.org/10.3390/clockssleep5010002
Perkiö A, Merikanto I, Kantojärvi K, Paunio T, Sinnott-Armstrong N, Jones SE, Ollila HM. Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals. Clocks & Sleep. 2023; 5(1):10-20. https://doi.org/10.3390/clockssleep5010002
Chicago/Turabian StylePerkiö, Anna, Ilona Merikanto, Katri Kantojärvi, Tiina Paunio, Nasa Sinnott-Armstrong, Samuel E. Jones, and Hanna M. Ollila. 2023. "Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals" Clocks & Sleep 5, no. 1: 10-20. https://doi.org/10.3390/clockssleep5010002