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Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules

1
Department of Psychology, University of California San Diego, La Jolla, CA 92093, USA
2
Center for Circadian Biology, University of California San Diego, La Jolla, CA 92093, USA
*
Authors to whom correspondence should be addressed.
Clocks & Sleep 2019, 1(3), 394-413; https://doi.org/10.3390/clockssleep1030032
Received: 30 June 2019 / Revised: 12 August 2019 / Accepted: 20 August 2019 / Published: 26 August 2019
The circadian system is generally considered to be incapable of adjusting to rapid changes in sleep/work demands. In shiftworkers this leads to chronic circadian disruption and sleep loss, which together predict underperformance at work and negative health consequences. Two distinct experimental protocols have been proposed to increase circadian flexibility in rodents using dim light at night: rhythm bifurcation and T-cycle (i.e., day length) entrainment. Successful translation of such protocols to human shiftworkers could facilitate alignment of internal time with external demands. To assess entrainment flexibility following bifurcation and exposure to T-cycles, mice in Study 1 were repeatedly phase-shifted. Mice from experimental conditions rapidly phase-shifted their activity, while control mice showed expected transient misalignment. In Study 2 and 3, mice followed a several weeks-long intervention designed to model a modified DuPont or Continental shiftwork schedule, respectively. For both schedules, bifurcation and nocturnal dim lighting reduced circadian misalignment. Together, these studies demonstrate proof of concept that mammalian circadian systems can be rendered sufficiently flexible to adapt to multiple, rapidly changing shiftwork schedules. Flexible adaptation to exotic light-dark cycles likely relies on entrainment mechanisms that are distinct from traditional entrainment. View Full-Text
Keywords: mouse; shiftwork; phase-shift; bifurcation; t-cycle; flexible entrainment; dim light mouse; shiftwork; phase-shift; bifurcation; t-cycle; flexible entrainment; dim light
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Walbeek, T.J.; Harrison, E.M.; Soler, R.R.; Gorman, M.R. Enhanced Circadian Entrainment in Mice and Its Utility under Human Shiftwork Schedules. Clocks & Sleep 2019, 1, 394-413.

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