Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review
Abstract
1. Introduction and Clinical Significance
2. Case Presentation
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
NF1 | Neurofibromatosis Type 1 |
PNST | Peripheral Nerve Sheath Tumor |
MPNST | Malignant Peripheral Nerve Sheath Tumor |
ANNUBP | Atypical Neurofibromatous Neoplasm of Uncertain Biologic Potential |
AN | Atypical Neurofibroma |
CDKN2A/B | Cyclin-Dependent Kinase Inhibitor 2A and 2B |
S100 | S100 protein (marker for neural/melanocytic cells) |
CD34 | Cluster of Differentiation 34 (marker for vascular/endothelial and fibroblastic cells) |
Ki-67 | Marker of cellular proliferation |
p53 | Tumor protein p53 (tumor suppressor) |
SMA/α-SMA | (Alpha-) Smooth Muscle Actin |
MRI | Magnetic Resonance Imaging |
HPF | High-Power Field (in microscopy) |
PET | Positron Emission Tomography |
FDG | Fluorodeoxyglucose (used in PET imaging) |
LG-MPNST | Low-Grade Malignant Peripheral Nerve Sheath Tumor |
WHO | World Health Organization |
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Tumor | Clinical Features | Histological Appearance | Immunohistochemical Appearance |
---|---|---|---|
Neurofibroma | Rubbery, often painless cutaneous or subcutaneous nodules; may cause itching, tenderness, or disfigurement (plexiform type); neurological deficits if deep or spinal involvement [2] | Mixed cellularity (Schwann cells, fibroblasts, perineural cells, mast cells) in myxoid stroma; wavy nuclei, “shredded-carrot” collagen [32] | S100 positivity in ~50% of cells; CD34-positive spindle fibroblasts (“fingerprint” pattern); occasional EMA in perineural cells; neurofilament in intratumoral axons [32] |
Schwannoma | Solitary or multiple, can be asymptomatic or cause pain/numbness/tingling; vestibular schwannoma → hearing loss, tinnitus, vertigo [20,30] | Encapsulated proliferation of Schwann cells with Antoni A (Verocay bodies) and Antoni B areas; absence of intralesional axons [20,32] | Diffuse, strong S100 positivity; calretinin+; CD56+; CD34 negative [32,33] |
MPNST | Rapidly enlarging painful mass, often in NF1 patients; new neurological deficits; systemic symptoms rare [21,31] | Hypercellular spindle cells in herringbone/fasciculated patterns, pleomorphism, high mitotic rate, necrosis [21,32] | Variable S100 (50–70%, often decreased in high-grade); p53+ in ~75%; EGFR+ in ~35%; loss of H3K27me3 [21,32] |
Lipoma | Soft, doughy, mobile subcutaneous mass; usually asymptomatic unless compressive [34,35] | Mature adipocytes with thin fibrous septa; often encapsulated [35] | Typically vimentin+; no diagnostic S100 or CD34 staining pattern described |
Epidermal Inclusion Cyst | Firm, freely movable nodules with central punctum; may become inflamed/infected, painful, discharge keratinous material [23] | Cyst lined by stratified squamous epithelium with granular layer; lumen filled with laminated keratin [23] | Not routinely characterized by IHC [23] |
DFSP | Indurated, slowly growing dermal plaque or nodule, often on trunk or proximal limbs; may mimic a bruise [24] | Uniform spindle cells in storiform (cartwheel) pattern; honeycomb infiltration of subcutis [24] | Strong CD34+; vimentin+; S100–, factor XIIIa– [24] |
Traumatic Neuroma | Painful/tender firm nodule at site of prior nerve injury or surgery [25] | Disorganized bundles of nerve fascicles (axons), Schwann cells and fibroblasts within collagenous scar [25] | S100+ in Schwann cells [25] |
Granular Cell Tumor | Solitary, painless, slow-growing nodules (commonly tongue, head/neck); may be multiple in syndromes [36,37] | Large polygonal cells with small nuclei, abundant eosinophilic granular cytoplasm; Pustulo-ovoid bodies of Milian; pseudoepitheliomatous hyperplasia of overlying epidermis [37] | Strong S100+; vimentin+; CD68 variably+; PAS-positive granules (diastase resistant) [37] |
Desmoid Tumor | Firm, sometimes painful mass in abdomen or extremities; associated with FAP or prior surgery/pregnancy [26] | Bland fibroblasts/myofibroblasts in sweeping fascicles; infiltrative borders; low mitoses [26] | Nuclear β-catenin+; vimentin+; SMA variably+; S100– [26] |
Dermal Neurotized Melanocytic Nevus | Pigmented dermal papule or nodule; may mimic neurofibroma clinically [27] | Neurotized nevus cells in dermis; may have increased mast cells [27] | Melan-A/MART-1 strong+ in nevus cells; S100+; neurofibromas are Melan-A [27] |
Aggressive Angiomyxoma | Deep perineal/pelvic mass in women of child-bearing age; often asymptomatic viscerally [28,38,39] | Low cellularity spindle cells in myxoid stroma with numerous blood vessels; infiltrative edges [28] | Estrogen and progesterone receptor+; vimentin+; desmin variably+ [28] |
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Gaydarski, L.; Georgiev, G.P.; Slavchev, S.A. Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review. Reports 2025, 8, 112. https://doi.org/10.3390/reports8030112
Gaydarski L, Georgiev GP, Slavchev SA. Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review. Reports. 2025; 8(3):112. https://doi.org/10.3390/reports8030112
Chicago/Turabian StyleGaydarski, Lyubomir, Georgi P. Georgiev, and Svetoslav A. Slavchev. 2025. "Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review" Reports 8, no. 3: 112. https://doi.org/10.3390/reports8030112
APA StyleGaydarski, L., Georgiev, G. P., & Slavchev, S. A. (2025). Giant Atypical Neurofibroma of the Calf in Neurofibromatosis Type 1: Case Report and Literature Review. Reports, 8(3), 112. https://doi.org/10.3390/reports8030112