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Open AccessCase Report

Effective Lenvatinib Treatment Complicated with Secondary Tracheocutaneous Fistula in Patients with Advanced Anaplastic Thyroid Carcinoma

by Wen-Chi Wu 1, Jiun-I Lai 2,3, Jui-Yu Chen 4 and Chun-Yu Liu 2,3,5,*
1
Department of Medicine, Taipei Veterans General Hospital, 11217 Taipei, Taiwan
2
Institute of Clinical Medicine, National Yang-Ming University, 11221 Taipei, Taiwan
3
Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, 11217 Taipei, Taiwan
4
Department of Surgery, Taipei Veterans General Hospital, 11217 Taipei, Taiwan
5
Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, 11217 Taipei, Taiwan
*
Author to whom correspondence should be addressed.
Reports 2019, 2(3), 22; https://doi.org/10.3390/reports2030022
Received: 9 August 2019 / Revised: 30 August 2019 / Accepted: 1 September 2019 / Published: 5 September 2019
(This article belongs to the Special Issue Case Reports in Oncology)
Anaplastic thyroid carcinoma (ATC) is a fatal disease with a poor prognosis. Lenvatinib is an oral multi-targeted tyrosine kinase inhibitor (TKI) which is approved in Japan for the treatment of ATC. Data of treatment response and adverse effects of lenvatinib in ATC patients is still relatively scarce, especially in non-Japanese patient populations. Here we report dramatic treatment effects of lenvatinib in two patients with stage IVc ATC, who later developed significant morbidities including tracheal perforation and fistula formation. Our cases demonstrate the efficacy and provide cautionary information for treatment of ATC. In treating advanced ATC patients with lenvatinib, close monitoring is highly recommended. View Full-Text
Keywords: lenvatinib; anaplastic thyroid carcinoma (ATC); tracheocutaneous fistula; tumor-cutaneous fistula; carotid blowout syndrome lenvatinib; anaplastic thyroid carcinoma (ATC); tracheocutaneous fistula; tumor-cutaneous fistula; carotid blowout syndrome
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Wu, W.-C.; Lai, J.-I.; Chen, J.-Y.; Liu, C.-Y. Effective Lenvatinib Treatment Complicated with Secondary Tracheocutaneous Fistula in Patients with Advanced Anaplastic Thyroid Carcinoma. Reports 2019, 2, 22.

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