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Reply to Shafaei B. Comment on “Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266”
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Reply published on 9 June 2025, see Adv. Respir. Med. 2025, 93(3), 16.
Comment of Adv. Respir. Med. 2022, 90(4), 254-266.
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Comment

Comment on Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266

by
Behnam Shafaei
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd 8916978477, Iran
Adv. Respir. Med. 2025, 93(3), 15; https://doi.org/10.3390/arm93030015
Submission received: 3 May 2025 / Accepted: 2 June 2025 / Published: 9 June 2025
Versions Notes
I am writing regarding the article titled “B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia” [1] by Sebastian Giraldo-Ocampo, Anilza Bonelo and Andres F. Zea-Vera, published in Advances in Respiratory Medicine, 2022.
Common variable immunodeficiency (CVID) refers to a heterogeneous group of primary immune deficiency diseases defined by decreased serum levels of Immunoglobulins (IgG, IgA, IgM), with impaired antibody production [2]. B-cells with CD21low expression are more expanded in these patients compared to healthy individuals [3].
In the fourth part of the Results Section of the article in question, “Alteration of B Cell Subsets Frequencies and Classification of PAD Participants”, it is stated that five CVID patients had more than one percent B-cells, and three out of five had an increase in CD21low B-cells. However, as shown in Table 2 of the paper [1], in which patients are categorized by EUROclass [4], only two of these five patients were CD21lo, and three were CD21norm.
This controversy raises questions about the true count of patients with CD21lo and would affect future studies on CD21lo expansion in patients.
I commend the authors for their decision to clarify the data and report accurate data for the benefit of readers and researchers.

Conflicts of Interest

The author declares no conflicts of interest.

References

  1. Giraldo-Ocampo, S.; Bonelo, A.; Zea-Vera, A.F. B cell subsets in Colombian adults with predominantly antibody deficiencies, bronchiectasis or recurrent pneumonia. Adv. Respir. Med. 2022, 90, 254–266. [Google Scholar] [CrossRef] [PubMed]
  2. Patuzzo, G.; Barbieri, A.; Tinazzi, E.; Veneri, D.; Argentino, G.; Moretta, F.; Lunardi, C. Autoimmunity and infection in common variable immunodeficiency (CVID). Autoimmun. Rev. 2016, 15, 877–882. [Google Scholar] [CrossRef] [PubMed]
  3. Wilfong, E.M.; Vowell, K.N.; Crofford, L.J.; Kendall, P.L. Multiparameter analysis of human B lymphocytes identifies heterogeneous CD19+ CD21lo subsets. Cytom. Part A 2023, 103, 283–294. [Google Scholar] [CrossRef] [PubMed]
  4. Wehr, C.; Kivioja, T.; Schmitt, C.; Ferry, B.; Witte, T.; Eren, E.; Warnatz, K. The EUROclass trial: Defining subgroups in common variable immunodeficiency. Blood J. Am. Soc. Hematol. 2008, 111, 77–85. [Google Scholar] [CrossRef] [PubMed]
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MDPI and ACS Style

Shafaei, B. Comment on Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266. Adv. Respir. Med. 2025, 93, 15. https://doi.org/10.3390/arm93030015

AMA Style

Shafaei B. Comment on Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266. Advances in Respiratory Medicine. 2025; 93(3):15. https://doi.org/10.3390/arm93030015

Chicago/Turabian Style

Shafaei, Behnam. 2025. "Comment on Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266" Advances in Respiratory Medicine 93, no. 3: 15. https://doi.org/10.3390/arm93030015

APA Style

Shafaei, B. (2025). Comment on Giraldo-Ocampo et al. B Cell Subsets in Colombian Adults with Predominantly Antibody Deficiencies, Bronchiectasis or Recurrent Pneumonia. Adv. Respir. Med. 2022, 90, 254–266. Advances in Respiratory Medicine, 93(3), 15. https://doi.org/10.3390/arm93030015

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