A Comparative Analysis of the Reinforcing Efficiency of Silsesquioxane Nanoparticles versus Apatite Nanoparticles in Chitosan Biocomposite Fibres
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation of Chitosan Fibres
2.2. Tensile Testing
2.3. Statistical Analysis
2.4. Weibull Model
3. Results
3.1. Fracture Morphology
3.2. Effects of Particle Type and Concentration on the Elastic Properties
3.3. Effects of Particle Type and Concentration on Fracture Properties
3.4. Mechanical Reliability
4. Discussion
4.1. Study Findings
4.2. Design for Reliability
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
- Fu, S.Y.; Feng, X.Q.; Lauke, B.; Mai, Y.W. Effects of particle size, particle/matrix interface adhesion and particle loading on mechanical properties of particulate-polymer composites. Compos. Part B 2008, 39, 933–961. [Google Scholar] [CrossRef]
- De Silva, R.T.; Pasbakhsh, P.; Goh, K.L.; Mishnaevsky, L. 3-D computational model of poly (lactic acid)/halloysite nanocomposites: Predicting elastic properties and stress analysis. Polymer 2014, 55. [Google Scholar] [CrossRef]
- De Silva, R.T.; Soheilmoghaddam, M.; Goh, K.L.; Wahit, M.U.; Bee, S.A.H.; Chai, S.-P.; Pasbakhsh, P. Influence of the processing methods on the properties of poly (lactic acid)/halloysite nanocomposites. Polym. Compos. 2016, 37, 861–869. [Google Scholar] [CrossRef]
- Khor, E.; Lim, L.Y. Implantable applications of chitin and chitosan. Biomaterials 2003, 24, 2339–2349. [Google Scholar] [CrossRef]
- Khalil, H.P.S.A.; Saurabh, C.K.; Adnan, A.S.; Fazita, M.R.N.; Syakir, M.I.; Davoudpour, Y.; Rafatullah, M.; Abdullah, C.K.; Haafiz, M.K.M.; Dungani, R. A review on chitosan-cellulose blends and nanocellulose reinforced chitosan biocomposites: Properties and their applications. Carbohydr. Polym. 2016, 150, 216–226. [Google Scholar] [CrossRef]
- Wysokowski, M.; Bazhenov, V.V.; Tsurkan, M.V.; Galli, R.; Stelling, A.L.; Stöcker, H.; Kaiser, S.; Niederschlag, E.; Gärtner, G.; Behm, T.; et al. Isolation and identification of chitin in three-dimensional skeleton of Aplysina fistularis marine sponge. Int. J. Biol. Macromol. 2013, 62, 94–100. [Google Scholar] [CrossRef] [PubMed]
- Wysokowski, M.; Petrenko, I.; Stelling, A.L.; Stawski, D.; Jesionowski, T.; Ehrlich, H. Poriferan chitin as a versatile template for extreme biomimetics. Polymers 2015, 7, 235–265. [Google Scholar] [CrossRef]
- Wysokowski, M.; Materna, K.; Walter, J.; Petrenko, I.; Stelling, A.L.; Bazhenov, V.V.; Klapiszewski, Ł.; Szatkowski, T.; Lewandowska, O.; Stawski, D.; et al. Solvothermal synthesis of hydrophobic chitin-polyhedral oligomeric silsesquioxane (POSS) nanocomposites. Int. J. Biol. Macromol. 2015, 78, 224–229. [Google Scholar] [CrossRef] [PubMed]
- Obara, K.; Ishihara, M.; Ishizuka, T.; Fujita, M. Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials 2003, 24, 3437–3444. [Google Scholar] [CrossRef]
- Cheng, M.; Deng, J.; Yang, F.; Gong, Y.; Zhao, N.; Zhang, X. Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions. Biomaterials 2003, 24, 2871–2880. [Google Scholar] [CrossRef]
- Malheiro, V.N.; Caridade, S.G.; Alves, N.M.; Mano, J.F. New poly (e-caprolactone)/chitosan blend fibers for tissue engineering applications. Acta Biomater. 2010, 6, 418–428. [Google Scholar] [CrossRef] [PubMed]
- Alves, N.M.; Mano, J.F. Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications. Int. J. Biol. Macromol. 2008, 43, 401–414. [Google Scholar] [CrossRef] [PubMed]
- Di Martino, A.; Sittinger, M.; Risbud, M.V. Chitosan: A versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 2005, 26, 5983–5990. [Google Scholar] [CrossRef] [PubMed]
- Albanna, M.Z.; Bou-Akl, T.H.; Blowytsky, O.; Walters, H.L.; Matthew, H.W.T. Chitosan fibers with improved biological and mechanical properties for tissue engineering applications. J. Mech. Behav. Biomed. Mater. 2013, 20, 217–226. [Google Scholar] [CrossRef] [PubMed]
- Liu, M.; Zhang, Y.; Wu, C.; Xiong, S.; Zhou, C. Chitosan/halloysite nanotubes bionanocomposites: Structure, mechanical properties and biocompatibility. Int. J. Biol. Macromol. 2012, 51, 566–575. [Google Scholar] [CrossRef] [PubMed]
- De Silva, R.T.; Pasbakhsh, P.; Goh, K.L.; Chai, S.-P.; Ismail, H. Physico-chemical characterisation of chitosan/halloysite composite membranes. Polym. Test. 2013, 32, 265–271. [Google Scholar] [CrossRef]
- Govindasamy, K.; Fernandopulle, C.; Pasbakhsh, P.; Goh, K.L. Synthesis and characterisation of electrospun chitosan membranes reinforced by halloysite nanotubes. J. Mech. Med. Biol. 2014, 14, 1450058. [Google Scholar] [CrossRef]
- Goh, K.L.; Listrat, A.; Béchet, D. Hierarchical mechanics of connective tissues: Integrating insights from nano to macroscopic studies. J. Biomed. Nanotechnol. 2014, 10, 2464–2507. [Google Scholar] [CrossRef]
- Wong, W.L.E.; Joyce, T.J.; Goh, K.L. Resolving the viscoelasticity and anisotropy dependence of the mechanical properties of skin from a porcine model. Biomech. Model. Mechanobiol. 2016, 15, 433–446. [Google Scholar] [CrossRef] [PubMed]
- Goh, K.L.; Holmes, D.F.; Lu, H.Y.; Richardson, S.; Kadler, K.E.; Purslow, P.P.; Wess, T.J. Ageing changes in the tensile properties of tendons : Influence of collagen fibril volume. J. Biomech. Eng. 2008, 130, 21011. [Google Scholar] [CrossRef] [PubMed]
- Goh, K.L.; Chen, Y.; Chou, S.M.; Listrat, A.; Bechet, D.; Wess, T.J.J. Effects of frozen storage temperature on the elasticity of tendons from a small murine model. Animal 2010, 4, 1613–1617. [Google Scholar] [CrossRef] [PubMed]
- Goh, K.L.; Holmes, D.F.; Lu, Y.; Purslow, P.P.; Kadler, K.E.; Bechet, D.; Wess, T.J. Bimodal collagen fibril diameter distributions direct age-related variations in tendon resilience and resistance to rupture. J. Appl. Physiol. 2012, 113, 878–888. [Google Scholar] [CrossRef] [PubMed]
- Yeo, Y.L.; Goh, K.L.; Kin, L.; Wang, H.J.; Listrat, A.; Bechet, D. Structure-property relationship of burn collagen reinforcing musculo-skeletal tissues. Key Eng. Mater. 2011, 478, 87–92. [Google Scholar] [CrossRef]
- Goh, K.L.; Chen, S.Y.; Liao, K. A thermomechanical framework for reconciling the effects of ultraviolet radiation exposure time and wavelength on connective tissue elasticity. Biomech. Model. Mechanobiol. 2014. [Google Scholar] [CrossRef] [PubMed]
- Xie, J.Z.; Hein, S.; Wang, K.; Liao, K.; Goh, K.L. Influence of hydroxyapatite crystallization temperature and concentration on stress transfer in wet-spun nanohydroxyapatite-chitosan composite fibres. Biomed. Mater. 2008, 3, 2–6. [Google Scholar] [CrossRef] [PubMed]
- Chew, S.L.; Wang, K.; Chai, S.P.; Goh, K.L. Elasticity, thermal stability and bioactivity of polyhedral oligomeric silsesquioxanes reinforced chitosan-based microfibres. J. Mater. Sci. Mater. Med. 2011, 22, 1365–1374. [Google Scholar] [CrossRef] [PubMed]
- Blanco, I.; Abate, L.; Bottino, F.A. Synthesis and thermal properties of new dumbbell-shaped isobutyl-substituted POSSs linked by aliphatic bridges. J. Therm. Anal. Calorim. 2014, 116, 5–13. [Google Scholar] [CrossRef]
- Guo, Y.-P.; Guan, J.-J.; Yang, J.; Wang, Y.; Zhang, C.-Q.; Ke, Q.-F. Hybrid nanostructured hydroxyapatite–chitosan composite scaffold: Bioinspired fabrication, mechanical properties and biological properties. J. Mater. Chem. B 2015, 3, 4679–4689. [Google Scholar] [CrossRef]
- Yamaguchi, I.; Tokuchi, K.; Fukuzaki, H.; Koyama, Y.; Takakuda, K.; Monma, H.; Tanaka, J. Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites. J. Biomed. Mater. Res. 2001, 55, 20–27. [Google Scholar] [CrossRef]
- De Silva, R.; Pasbakhsh, P.; Qureshi, A.J.; Gibson, A.G.; Goh, K.L. Stress transfer and fracture in nanostructured particulate-reinforced chitosan biopolymer composites: Influence of interfacial shear stress and particle slenderness. Compos. Interfaces 2014, 21, 807–818. [Google Scholar] [CrossRef]
- Peniche, C.; Solís, Y.; Davidenko, N.; García, R. Chitosan/hydroxyapatite-based composites. Biotecnol. Apl. 2010, 27, 202–210. [Google Scholar]
- Pighinelli, L.; Kucharska, M. Properties and structure of microcrystalline chitosan and hydroxyapatite composites. J. Biomater. Nanobiotechnol. 2014, 5, 128–138. [Google Scholar] [CrossRef]
- Wang, Z.; Hu, Q. Preparation and properties of three-dimensional hydroxyapatite/chitosan nanocomposite rods. Biomed. Mater. 2010, 5, 45007. [Google Scholar] [CrossRef] [PubMed]
- Wang, K.; Liao, K.; Goh, K.L. How sensitive is the elasticity of hydroxyapatite-nanoparticle- reinforced chitosan composite to changes in particle concentration and crystallization temperature? J. Funct. Biomater. 2015, 6, 986–998. [Google Scholar] [CrossRef] [PubMed]
- Tishchenko, G.; Bleha, M. Diffusion permeability of hybrid chitosan/polyhedral oligomeric silsesquioxanes (POSS) membranes to amino acids. J. Membr. Sci. 2005, 248, 45–51. [Google Scholar] [CrossRef]
- Xu, D.; Loo, L.S.; Wang, K. Pervaporation performance of novel chitosan-POSS hybrid membranes: Effects of POSS and operating conditions. J. Polym. Sci. Part B 2010, 48, 2185–2192. [Google Scholar] [CrossRef]
- Reno, F.; Carniato, F.; Rizzi, M.; Marchese, L.; Laus, M.; Antonioli, D.; Ren, F. POSS/gelatin-polyglutamic acid hydrogel composites: Preparation, biological and mechanical characterization. J. Appl. Polym. Sci. 2013, 699–706. [Google Scholar] [CrossRef]
- Zhang, W.; Camino, G.; Yang, R. Polymer/polyhedral oligomeric silsesquioxane (POSS) nanocomposites: An overview of fire retardance. Prog. Polym. Sci. 2017, 67, 77–125. [Google Scholar] [CrossRef]
- Blanco, I.; Bottino, F.A.; Cicala, G.; Latteri, A.; Recca, A. Synthesis and Characterization of Differently Substituted Phenyl Hepta Isobutyl-Polyhedral Oligomeric Silsesquioxane/Polystyrene Nanocomposites. Polym. Compos. 2014, 35, 151–157. [Google Scholar] [CrossRef]
- Andrade, R.J.; Weinrich, Z.N.; Ferreira, C.I.; Schiraldi, D.A.; Maia, J.M. Optimization of Melt Blending Process of Nylon 6-POSS: Improving mechanical properties of spun fibers. Polym. Eng. Sci. 2015, 55, 1580–1587. [Google Scholar] [CrossRef]
- Raftopoulos, K.N.; Pielichowski, K. Segmental dynamics in hybrid polymer/POSS nanomaterials. Prog. Polym. Sci. 2016, 52, 136–187. [Google Scholar] [CrossRef]
- Lee, S.; Park, S.; Kim, Y. Effect of the concentration of sodium acetate (SA) on crosslinking of chitosan fiber by epichlorohydrin (ECH) in a wet spinning system. Carbohydr. Polym. 2007, 70, 53–60. [Google Scholar] [CrossRef]
- Wang, K.; Loo, L.S.; Goh, K.L. A facile method for processing lignin reinforced chitosan biopolymer microfibres: Optimising the fibre mechanical properties through lignin type and concentration. Mater. Res. Express 2016, 3. [Google Scholar] [CrossRef]
- Weibull, W. A statistical distribution function of wide applicability. ASME J. Appl. Mech. 1951, 18, 293–297. [Google Scholar]
- O’Brien, F.J.; Harley, B.A.; Yannas, I.V.; Gibson, L.J. The effect of pore size on cell adhesion in collagen-GAG scaffolds. Biomaterials 2005, 26, 433–441. [Google Scholar] [CrossRef] [PubMed]
- O’Brien, F.J. Biomaterials & scaffolds for tissue engineering. Mater. Today 2011, 14, 88–95. [Google Scholar]
- Ramshaw, J.A.M.; Werkmeister, J.A.; Dumsday, G.J. Emerging directions for biomedical materials Bioengineered collagens. Bioengineered 2017, 5, 227–233. [Google Scholar] [CrossRef] [PubMed]
- Bhattarai, N.; Edmondson, D.; Veiseh, O.; Matsen, F.A.; Zhang, M. Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 2005, 26, 6176–6184. [Google Scholar] [CrossRef] [PubMed]
- Goh, K.L. Discontinuous-Fibre Reinforced Composites: Fundamentals of Stress Transfer and Fracture Mechanics; Springer: London, UK, 2017. [Google Scholar] [CrossRef]
- Sadat-Shojai, M.; Khorasani, M.-T.; Jamshidi, A. Hydrothermal processing of hydroxyapatite nanoparticles—A Taguchi experimental design approach. J. Cryst. Growth 2012, 361, 73–84. [Google Scholar] [CrossRef]
- Sadat-Shojai, M.; Khorasani, M.-T.; Dinpanah-Khoshdargi, E.; Jamshidi, A. Synthesis methods for nanosized hydroxyapatite with diverse structures. Acta Biomater. 2013, 9, 7591–7621. [Google Scholar] [CrossRef] [PubMed]
- Notin, L.; Viton, C.; David, L.; Alcouffe, P.; Rochas, C.; Domard, A. Morphology and mechanical properties of chitosan fibers obtained by gel-spinning: Influence of the dry-jet-stretching step and ageing. Acta Biomater. 2006, 2, 387–402. [Google Scholar] [CrossRef] [PubMed]
- Denkba, E.B.; Seyyal, M.; Piskin, E. ImplanTable 5-fluorouracil loaded chitosan scaffolds prepared by wet spinning. J. Membr. Sci. 2000, 172, 33–38. [Google Scholar] [CrossRef]
- Chen, Z.G.; Wang, P.W.; Wei, B.; Mo, X.M.; Cui, F.Z. Electrospun collagen–chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell. Acta Biomater. 2010, 6, 372–382. [Google Scholar] [CrossRef] [PubMed]
- Kumar, R.; Prakash, K.H.; Cheang, P.; Khor, K.A. Temperature driven morphological changes of chemically precipitated hydroxyapatite nanoparticles. Langmuir 2004, 8, 5196–5200. [Google Scholar] [CrossRef]
- Banerjee, A.; Bandyopadhyay, A.; Bose, S. Hydroxyapatite nanopowders: Synthesis, densification and cell–materials interaction. Mater. Sci. Eng. C 2007, 27, 729–735. [Google Scholar] [CrossRef]
- Strachota, A.; Tishchenko, G.; Matejka, L.; Bleha, M. Chitosan–oligo(silsesquioxane) blend membranes: Preparation, morphology, and diffusion permeability. J. Inorg. Organomet. Polym. 2002, 11, 165–182. [Google Scholar] [CrossRef]
- Kopesky, E.T.; McKinley, G.H.; Cohen, R.E. Toughened poly(methyl methacrylate) nanocomposites by incorporating polyhedral oligomeric silsesquioxanes. Polymer 2006, 47, 299–309. [Google Scholar] [CrossRef]
- Ayandele, E.; Sarkar, B.; Alexandridis, P. Polyhedral oligomeric silsesquioxane (POSS)-containing polymer nanocomosites. Nanomaterials 2012, 2, 445–475. [Google Scholar] [CrossRef] [PubMed]
- Motskin, M.; Wright, D.M.; Muller, K.; Kyle, N.; Gard, T.G.; Porter, A.E.; Skepper, J.N. Biomaterials hydroxyapatite nano and microparticles: Correlation of particle properties with cytotoxicity and biostability. Biomaterials 2009, 30, 3307–3317. [Google Scholar] [CrossRef] [PubMed]
- Goh, K.L.; Aspden, R.M.; Mathias, K.J.; Hukins, D.W.L. Finite-element analysis of the effect of material properties and fibre shape on stresses in an elastic fibre embedded in an elastic matrix in a fibre-composite material. Proc. R. Soc. Lond. A 2004, 2339–2352. [Google Scholar] [CrossRef]
- Goh, K.L.; Aspden, R.M.; Mathias, K.J.; Hukins, D.W.L. Effect of fibre shape on the stresses within fibres in fibre-reinforced composite materials. Proc. R. Soc. Lond. A 1999, 455, 3351–3361. [Google Scholar] [CrossRef]
- Goh, K.L.; Aspden, R.M.; Hukins, D.W.L. Review: Finite element analysis of stress transfer in short-fibre composite materials. Compos. Sci. Technol. 2004, 64, 1091–1100. [Google Scholar] [CrossRef]
- Fu, S.; Xu, G.; Mai, Y. On the elastic modulus of hybrid particle/short-fiber/polymer composites. Compos. Part B 2002, 33, 291–299. [Google Scholar] [CrossRef]
- Venkateshwaran, N.; Elayaperumal, A.; Sathiya, G.K. Prediction of tensile properties of hybrid-natural fiber composites. Compos. Part B 2012, 43, 793–796. [Google Scholar] [CrossRef]
- Wang, K.; Wu, J.; Ye, L.; Zeng, H. Mechanical properties and toughening mechanisms of polypropylene/barium sulfate composites. Compos. Part A 2003, 34, 1199–1205. [Google Scholar] [CrossRef]
- Estili, M.; Sakka, Y. Recent advances in understanding the reinforcing ability and mechanism of carbon nanotubes in ceramic matrix composites. Sci. Technol. Adv. Mater. 2014, 15, 64902. [Google Scholar] [CrossRef] [PubMed]
- Wang, H.W.; Zhou, H.W.; Peng, R.D.; Mishnaevsky, L. Nanoreinforced polymer composites: 3D FEM modeling with effective interface concept. Compos. Sci. Technol. 2011, 71, 980–988. [Google Scholar] [CrossRef]
- Aranaz, I.; Martínez-Campos, E.; Moreno-Vicente, C.; Civantos, A.; García-Arguelles, S.; del Monte, F. Macroporous calcium phosphate/chitosan composites prepared via unidirectional ice segregation and subsequent freeze-drying. Materials 2017, 10, 516. [Google Scholar] [CrossRef] [PubMed]
- Irvine, S.A.; Venkatraman, S.S. Bioprinting and differentiation of stem cells. Molecules 2016, 21, 1188. [Google Scholar] [CrossRef] [PubMed]
- Lange, F.F.; Radford, K.C. Fracture energy of an epoxy composite system. J. Mater. Sci. 1971, 6, 1197–1203. [Google Scholar] [CrossRef]
- Sadat-Shojai, M.; Atai, M.; Nodehi, A.; Khanlar, L.N. Hydroxyapatite nanorods as novel fillers for improving the properties of dental adhesives: Synthesis and application. Dent. Mater. 2010, 26, 471–482. [Google Scholar] [CrossRef] [PubMed]
Particle Concentration % w/w | CS/HA | CS/POSS | ||||||
---|---|---|---|---|---|---|---|---|
Yield Strength | Fracture Strength | Yield Strength | Fracture Strength | |||||
β (MPa) | σ0 (MPa) | β (MPa) | σ0 (MPa) | β (MPa) | σ0 (MPa) | β (MPa) | σ0 (MPa) | |
1 | 4.58 | 37.53 | 7.21 | 69.43 | 2.40 | 31.76 | 13.00 | 58.96 |
3 | 4.80 | 38.31 | 12.90 | 86.26 | 7.90 | 48.11 | 4.70 | 85.35 |
5 | 4.90 | 35.57 | 9.80 | 70.46 | 4.40 | 42.52 | 3.50 | 83.81 |
7 | 5.30 | 32.80 | 15.80 | 62.76 | 2.60 | 37.17 | 13.30 | 97.41 |
9 | 3.70 | 24.27 | 7.80 | 55.30 | 2.50 | 32.46 | 9.40 | 50.68 |
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Wang, K.; Pasbakhsh, P.; De Silva, R.T.; Goh, K.L. A Comparative Analysis of the Reinforcing Efficiency of Silsesquioxane Nanoparticles versus Apatite Nanoparticles in Chitosan Biocomposite Fibres. J. Compos. Sci. 2017, 1, 9. https://doi.org/10.3390/jcs1010009
Wang K, Pasbakhsh P, De Silva RT, Goh KL. A Comparative Analysis of the Reinforcing Efficiency of Silsesquioxane Nanoparticles versus Apatite Nanoparticles in Chitosan Biocomposite Fibres. Journal of Composites Science. 2017; 1(1):9. https://doi.org/10.3390/jcs1010009
Chicago/Turabian StyleWang, Kean, Pooria Pasbakhsh, Rangika Thilan De Silva, and Kheng Lim Goh. 2017. "A Comparative Analysis of the Reinforcing Efficiency of Silsesquioxane Nanoparticles versus Apatite Nanoparticles in Chitosan Biocomposite Fibres" Journal of Composites Science 1, no. 1: 9. https://doi.org/10.3390/jcs1010009