Endoplasmic Reticulum Stress in Hearing Loss
Abstract
:1. Introduction
2. ER Stress and Drug-Induced Hearing Loss
3. ER Stress and Noise-Induced Hearing Loss
4. ER Stress and Age-Related Hearing Loss
5. ER Stress and Hereditary Hearing Loss
5.1. WFS1 and ER Stress
5.2. Connexins and ER Stress
5.3. USH Proteins and ER Stress
6. Conclusions and Perspectives
Acknowledgments
Conflicts of Interest
References
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Hearing loss | Alteration in ER Stress | Models | ER Stress-Related Treatment | References |
---|---|---|---|---|
DIHL | ||||
3-NP | ATF4 ↑, CHOP ↑ | Rat/guinea pig cochlea | GGA | [39,56] |
APAP | p-eIF2α ↑, CHOP ↑ | HEI-OC1 cell | [40] | |
NAPQI | p-eIF2α ↓, CHOP ↑ | HEI-OC1 cell | [40] | |
Aminoglycosides | All 3 UPR pathways ↑ | HEK cell, mouse cochlea | TUDCA | [41] |
NIHL | Bip ↑, CHOP ↑ | Guinea pig/mouse cochlea | SA4503,GGA | [44,45,50,55] |
ARHL | Bip ↓, CHOP ↑ | Mouse cochlea | GGA | [51,54] |
Deafness Gene | Alteration in ER Stress | Models | ER Stress-Related Treatment | References |
---|---|---|---|---|
WFS1 | ATF6α pathway ↑ | Knockdown cells | [63,64] | |
All 3 UPR pathways ↑ | Knockout mouse pancreas | [64,71] | ||
IRE1α pathway ↑ | Knockout mouse retina | [72] | ||
ATF6α pathway ↑ | Mutant overexpressed cells | [78,79,80] | ||
GJB3 | All 3 UPR pathways ↑ | Mutant overexpressed cells * | [95] | |
Bip ↑ | Mutant overexpressed cells | [101] | ||
CDH23 | PERK pathway ↑ | Mutant mouse cochlea | Salubrinal | [61] |
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Wang, Y.; Liu, X.; Xu, Z. Endoplasmic Reticulum Stress in Hearing Loss. J. Otorhinolaryngol. Hear. Balance Med. 2018, 1, 3. https://doi.org/10.3390/ohbm1010003
Wang Y, Liu X, Xu Z. Endoplasmic Reticulum Stress in Hearing Loss. Journal of Otorhinolaryngology, Hearing and Balance Medicine. 2018; 1(1):3. https://doi.org/10.3390/ohbm1010003
Chicago/Turabian StyleWang, Yanfei, Xiangguo Liu, and Zhigang Xu. 2018. "Endoplasmic Reticulum Stress in Hearing Loss" Journal of Otorhinolaryngology, Hearing and Balance Medicine 1, no. 1: 3. https://doi.org/10.3390/ohbm1010003