Preparation and Hydro-Lipophilic Properties of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides†
AbstractA series of variously methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-carboxanilides was prepared and characterized as potential anti-invasive agents. As it is known that lipophilicity significantly influences the biological activity of compounds, the hydro-lipophilic properties of these mono-, di- and tri-substituted 1-hydroxynaphthalene-2-carboxanilides are investigated in the study. All the discussed hydroxynaphthalene derivatives were analyzed using the reversed-phase, high-performance liquid chromatography method, to measure lipophilicity. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase, using an end-capped, non-polar C18 stationary reversed-phase column. The present study discusses the correlations between the logarithm of the capacity factor k and log P/Clog P values, calculated in various ways, as well as the relationships between the lipophilicity and the chemical structure of the studied compounds.
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Kapustikova, I.; Gonec, T.; Kos, J.; Spaczynska, E.; Oravec, M.; Dohanosova, J.; Liptaj, T.; Musiol, R.; Jampilek, J. Preparation and Hydro-Lipophilic Properties of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides. Proceedings 2019, 9, 43.
Kapustikova I, Gonec T, Kos J, Spaczynska E, Oravec M, Dohanosova J, Liptaj T, Musiol R, Jampilek J. Preparation and Hydro-Lipophilic Properties of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides. Proceedings. 2019; 9(1):43.Chicago/Turabian Style
Kapustikova, Iva; Gonec, Tomas; Kos, Jiri; Spaczynska, Ewelina; Oravec, Michal; Dohanosova, Jana; Liptaj, Tibor; Musiol, Robert; Jampilek, Josef. 2019. "Preparation and Hydro-Lipophilic Properties of Methoxylated and Methylated 1-Hydroxynaphthalene-2-Carboxanilides." Proceedings 9, no. 1: 43.
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